AB129096

重组Anti-proCNP抗体[EPR6543]

Anti-proCNP antibody [EPR6543]

RabMAb
Recombinant
了解详情

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(1 Publication)

Rabbit Recombinant Monoclonal proCNP antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.

查看别名

CNP2, NPPC, C-type natriuretic peptide

1 Images

Unknown

Western blot - Anti-proCNP antibody [EPR6543] (AB129096)

All lanes:

Western blot - Anti-proCNP antibody [EPR6543] (ab129096) at 1/10000 dilution

All lanes:

Human proCNP recombinant protein at 0.01 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 13 kDa

Observed band size: 6 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-proCNP antibody [EPR6543] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR6543

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "NOTE: ab129096 has only been tested against the recombinant protein .", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ProCNP also known as pro-C-type natriuretic peptide is an inactive precursor to C-type natriuretic peptide (CNP) a member of the natriuretic peptide family. ProCNP has a molecular mass of approximately 12 kDa. This peptide is particularly expressed in the central nervous system bones and blood vessels. CNP is widely distributed in brain tissues and offers significant biological effects in these areas which are contrasted to the limited distribution and distinct functions of the other natriuretic peptides.

Biological function summary

Pro-C-type natriuretic peptide plays an important role in the regulation of vascular tone and bone growth. It does not act on its own but must be processed into active CNP to exert its functions. CNP does not work as part of a complex but directly interacts with particulate guanylyl cyclase membrane receptor-B (NPR-B) which mediates its effects on target tissues by increasing cyclic guanosine monophosphate (cGMP) levels.

Pathways

ProCNP influences two main pathways: the natriuretic peptide signaling pathway and bone development pathways. In particular CNP derived from proCNP regulates endochondral ossification and promotes chondrocyte differentiation. This regulation is essential in growth plate development and bone lengthening. CNP associated with natriuretic peptide receptor B contrasts with atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) which more intensely modulate cardiovascular functions.

ProCNP when processed to CNP demonstrates a link to achondroplasia a genetic disorder of bone growth leading to dwarfism. Alterations in the CNP-NPR-B pathway due to genetic mutations can impair normal bone development. Moreover it has an association with cardiovascular conditions where abnormal levels affect vascular homeostasis. These effects relate to the interaction with other natriuretic peptides like BNP as studies frequently measure proCNP levels alongside BNP in heart-related assessments.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

CNP-22. Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic (PubMed : 1672777). Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed : 1672777, PubMed : 21098034). Binds the clearance receptor NPR3 (PubMed : 11533490).

See full target information NPPC

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cancers 17: PubMed40361334

2025

Roles of Annexin A1 Expression in Small Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ágnes Paál,David Dora,Ákos Takács,Christopher Rivard,Shivaun Lueke Pickard,Fred R Hirsch,Brigitta Roskó,Peter Kiraly,Péter Ferdinandy,Zoltán V Varga,Zoltan Lohinai,Anikó Görbe

View all publications

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重组Anti-proCNP抗体[EPR6543]