Anti-pro Caspase-12抗体(ab8117)
Key features and details
- Rabbit polyclonal to pro Caspase-12
- Suitable for: IHC-P, ICC/IF, WB
- Reacts with: Mouse
- Isotype: IgG
概述
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产品名称
Anti-pro Caspase-12抗体
参阅全部 pro Caspase-12 一抗 -
描述
兔多克隆抗体to pro Caspase-12 -
宿主
Rabbit -
特异性
The antibody only recognizes the prodomain, not the activated form. -
经测试应用
适用于: IHC-P, ICC/IF, WBmore details -
种属反应性
与反应: Mouse -
免疫原
Synthetic peptide corresponding to Mouse pro Caspase-12 aa 100-200.
Database link: O08736 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. Do Not Freeze. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide -
Concentration information loading... -
纯度
Affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use a concentration of 2 µg/ml.
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| ICC/IF |
Use a concentration of 20 µg/ml.
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| WB |
Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 55 kDa.
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| 说明 |
|---|
|
IHC-P
Use a concentration of 2 µg/ml. |
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ICC/IF
Use a concentration of 20 µg/ml. |
|
WB
Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 55 kDa. |
靶标
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相关性
Caspase 12 is activated by ER stress, including disruption of ER calcium homeostasis and mediates ER stress-induced apoptosis. Caspase 12 is co-localized to the ER with several proteins that are involved in Alzheimers disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase 12 mediates cytotoxicity induced by amyloid-beta. It is ubiquitously expressed in mouse tissue. -
细胞定位
Endoplasmic reticulum -
数据库链接
- Entrez Gene: 12364 Mouse
- SwissProt: O08736 Mouse
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别名
- CASP12 antibody
- CASP12P1 antibody
图片
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Western blot - Anti-pro Caspase-12 antibody (ab8117)All lanes : Anti-pro Caspase-12 antibody (ab8117) at 1 µg/ml
Lane 1 : Murine brain tissue lysate with absence of blocking peptide
Lane 2 : Murine brain tissue lysate with presence of blocking peptide -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-pro Caspase-12 antibody (ab8117)ab8117 staining Caspase-12 in mouse liver tissue by IHC
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Immunocytochemistry/ Immunofluorescence - Anti-pro Caspase-12 antibody (ab8117)Immunofluorescence of Caspase-12 in Mouse Liver cells using ab8117 at 10 ug/ml.
实验方案
数据表及文件
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Datasheet download
文献 (7)
ab8117 被引用在 7 文献中.
- Wang S et al. LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis. Aging (Albany NY) 14:6809-6828 (2022). PubMed: 36044268
- Ji J et al. Activating PPARβ/δ Protects against Endoplasmic Reticulum Stress-Induced Astrocytic Apoptosis via UCP2-Dependent Mitophagy in Depressive Model. Int J Mol Sci 23:N/A (2022). PubMed: 36142731
- Chen W et al. Honokiol inhibits endoplasmic reticulum stress-associated lipopolysaccharide-induced inflammation and apoptosis in bovine endometrial epithelial cells. Exp Ther Med 22:1476 (2021). PubMed: 34765017
- Hu HJ et al. Hydrogen Sulfide Ameliorates Angiotensin II-Induced Atrial Fibrosis Progression to Atrial Fibrillation Through Inhibition of the Warburg Effect and Endoplasmic Reticulum Stress. Front Pharmacol 12:690371 (2021). PubMed: 34950023
- Liu H et al. YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway. Oncol Lett 18:6752-6758 (2019). PubMed: 31807184
- Shen B et al. Mechanism of HN-3 cell apoptosis induced by carboplatin: Combination of mitochondrial pathway associated with Ca2+ and the nucleus pathways. Mol Med Rep 18:4978-4986 (2018). PubMed: 30272304
- Fatma N et al. Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis. Am J Physiol Cell Physiol 301:C954-67 (2011). PubMed: 21677259
