Anti-PR3 抗体 [WGM2]
Anti-PR3 antibody [WGM2]
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(13 Publications)
Mouse Monoclonal PR3 antibody. Suitable for Flow Cyt, ELISA, WB, IHC-P, FuncS, Inhib, IHC-Fr and reacts with Human samples. Cited in 13 publications.
查看别名
MBN, PRTN3, Myeloblastin, AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen, PR-3, PR3, NP-4
不同偶联物与剂型 (1)
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519 FITC
FITC Anti-PR3 antibody [WGM2]
反应性数据
产品详情
性能和储存信息
形式
纯化工艺
纯化说明
存储溶液
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Proteinase 3 serves multiple roles including modulating inflammation and immune responses. PR3 functions as part of a complex with azurophilic granules aiding in microbial defense mechanisms. In addition the protease regulates cytokine activation and deactivation which in turn influences cell signaling related to inflammation. Its enzymatic action ensures that PR3 can manage inflammatory processes by breaking down extracellular matrix components thereby allowing white blood cells to access infection sites.
Pathways
Proteinase 3 plays an important role within the serine protease and inflammatory pathways. It interacts with other proteins such as neutrophil elastase with which it shares a pathway to modulate immune responses. PR3 also partners with cathepsin G contributing to processes such as pathogen clearance and tissue remodeling providing a coordinated response during infection and injury. These interactions show PR3's involvement in regulating the balance between inflammation and tissue repair.
产品实验方案
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靶点信息
文献 (13)
Recent publications for all applications. Explore the full list and refine your search
Oncoimmunology 11:2052418 PubMed35309732
2022
Applications
Unspecified application
Species
Unspecified reactive species
BMC immunology 20:22 PubMed31248381
2019
Applications
Unspecified application
Species
Unspecified reactive species
Journal of the American Chemical Society 139:10115-10125 PubMed28672107
2017
Applications
Unspecified application
Species
Unspecified reactive species
Disease models & mechanisms 9:885-97 PubMed27483354
2016
Applications
Unspecified application
Species
Human
PloS one 9:e110677 PubMed25330301
2014
Applications
Unspecified application
Species
Unspecified reactive species
Arthritis research & therapy 16:R142 PubMed25000985
2014
Applications
Unspecified application
Species
Unspecified reactive species
Innate immunity 20:440-8 PubMed24189124
2013
Applications
Unspecified application
Species
Human
Journal of immunology (Baltimore, Md. : 1950) 189:5476-84 PubMed23105141
2012
Applications
Unspecified application
Species
Unspecified reactive species
PloS one 7:e38317 PubMed22675451
2012
Applications
Flow Cyt
Species
Human
Rheumatology (Oxford, England) 41:1313-7 PubMed12422006
2002
Applications
Unspecified application
Species
Unspecified reactive species
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