Anti-Polymeric immunoglobulin receptor/PIGR抗体(ab96196)
Key features and details
- Rabbit polyclonal to Polymeric immunoglobulin receptor/PIGR
- Suitable for: WB, IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Polymeric immunoglobulin receptor/PIGR抗体
参阅全部 Polymeric immunoglobulin receptor/PIGR 一抗 -
描述
兔多克隆抗体to Polymeric immunoglobulin receptor/PIGR -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-P, ICC/IFmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fragment corresponding to Human Polymeric immunoglobulin receptor/PIGR aa 180-429.
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阳性对照
- 293T, A431, H1299, HeLa, HepG2, Molt4 and Raji cells; Cal27 xenograft tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab96196于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (3) |
1/500 - 1/300. Predicted molecular weight: 83 kDa.
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| IHC-P |
1/100 - 1/500.
|
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| ICC/IF | (2) |
1/100 - 1/200.
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| 说明 |
|---|
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WB
1/500 - 1/300. Predicted molecular weight: 83 kDa. |
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IHC-P
1/100 - 1/500. |
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ICC/IF
1/100 - 1/200. |
靶标
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功能
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. -
序列相似性
Contains 5 Ig-like V-type (immunoglobulin-like) domains. -
翻译后修饰
N-glycosylation is not necessary for Ig binding. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 5284 Human
- Omim: 173880 Human
- SwissProt: P01833 Human
- Unigene: 497589 Human
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别名
- Hepatocellular carcinoma associated protein TB6 antibody
- Hepatocellular carcinoma-associated protein TB6 antibody
- MGC125361 antibody
see all
图片
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Western blot - Anti-Polymeric immunoglobulin receptor/PIGR antibody (ab96196)Anti-Polymeric immunoglobulin receptor/PIGR antibody (ab96196) at 1/1000 dilution + Molt4 whole cell lysate at 30 µg
Predicted band size: 83 kDa -
Immunocytochemistry/ Immunofluorescence - Anti-Polymeric immunoglobulin receptor/PIGR antibody (ab96196)ab96196 at 1/200 dilution staining Polymeric immunoglobulin receptor/PIGR in methanol fixed HepG2 cells. Lower image is co-stained with Hoechst 33342.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Polymeric immunoglobulin receptor/PIGR antibody (ab96196)ab96196 at 1/500 dilution staining Polymeric immunoglobulin receptor/PIGR in paraffin-embedded Cal27 xenograft tissue.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (8)
ab96196 被引用在 8 文献中.
- Deluco B & Wilson HL Assessment of intestinal macromolecular absorption in young piglets to pave the way to oral vaccination: preliminary results. Vet Res Commun 46:79-91 (2022). PubMed: 34559380
- Biswas S et al. IgA transcytosis and antigen recognition govern ovarian cancer immunity. Nature N/A:N/A (2021). PubMed: 33536615
- Ohkuma R et al. High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer. Oncol Rep 44:252-262 (2020). PubMed: 32627041
- Deleon-Pennell KY et al. Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure. ACS Omega 4:1272-1280 (2019). PubMed: 30729226
- Zhou M et al. Expression of polymeric immunoglobulin receptor and its biological function in endometrial adenocarcinoma. J Cancer Res Ther 15:420-425 (2019). PubMed: 30964121
- Huang L et al. A study on the mechanism of agonists in regulating transcriptional level of pIgR in salivary gland epithelial cells. Exp Ther Med 16:4367-4372 (2018). PubMed: 30542385
- Minghui Z et al. Analysis of Differentially Expressed Proteins Involved in Autoimmune Cirrhosis and Normal Serum by iTRAQ Proteomics. Proteomics Clin Appl N/A:e1700153 (2018). PubMed: 29999587
- Casey CA et al. Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver Cells. Biomolecules 8:N/A (2018). PubMed: 30453527