AB167368

Anti-POLRMT抗体

Name: POLRMT抗体 (ab167368)| Abcam中文官网
Brand: Abcam Limited
SKU: AB167368
Price: 4560 CNY
Availability: InStock

Anti-POLRMT antibody

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(3 Publications)

Mouse Polyclonal POLRMT antibody. Suitable for WB and reacts with Transfected cell lysate samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human POLRMT.

查看别名

MtRPOL, POLRMT

1 Images

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Western blot - Anti-POLRMT antibody (AB167368)

All lanes:

Western blot - Anti-POLRMT antibody (ab167368) at 1 µg/mL

Lane 1:

POLRMT transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG at 1/2500 dilution

Predicted band size: 139 kDa

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关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

应用

applications

免疫原

Recombinant Full Length Protein corresponding to Human POLRMT.

O00411

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Transfected cell lysate": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p>This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed : 21278163, PubMed : 33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed : 29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed : 29149603). Has DNA primase activity (PubMed : 18685103, PubMed : 33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed : 18685103, PubMed : 33602924).

See full target information POLRMT

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 43:2337-2367 PubMed38649537

2024

SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression.

Applications

Unspecified application

Species

Unspecified reactive species

Weiwei Yan,Chengmei Xie,Sijun Sun,Quan Zheng,Jingyi Wang,Zihao Wang,Cheuk-Him Man,Haiyan Wang,Yunfan Yang,Tianshi Wang,Leilei Shi,Shengjie Zhang,Chen Huang,Shuangnian Xu,Yi-Ping Wang

Cell metabolism 33:1027-1041.e8 PubMed33770508

2021

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Ping Wang,Azeem Sharda,Shuang-Nian Xu,Nick van Gastel,Cheuk Him Man,Una Choi,Wei Zhong Leong,Xi Li,David T Scadden

Molecular medicine reports 20:1113-1120 PubMed31173210

2019

Electroacupuncture alleviates morphine‑induced hyperalgesia by regulating spinal CB1 receptors and ERK1/2 activity.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxin Zheng,Yang Yu,Keliang Xie,Yuan Yuan,Yi Chen,Chunyan Wang,Guolin Wang,Yonghao Yu

View all publications

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Anti-POLRMT抗体

Anti-POLRMT antibody

Western blot - Anti-POLRMT antibody (AB167368)