Anti-PLOD3抗体(ab128698)
Key features and details
- Rabbit polyclonal to PLOD3
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-PLOD3抗体
参阅全部 PLOD3 一抗 -
描述
兔多克隆抗体to PLOD3 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Recombinant fragment, corresponding to amino acids 254-508 of Human PLOD3 (BC011674).
-
阳性对照
- human fetal kidney lysate for western blot, formalin-fixed paraffin-embedded human fetal small intestine for ICH-P
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Lyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
Preservative: 0.02% Sodium azide
Constituent: 1% BSA -
Concentration information loading...
-
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab128698于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
1/100 - 1/500.
|
说明 |
---|
IHC-P
1/100 - 1/500. |
靶标
-
功能
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. -
疾病相关
Defects in PLOD3 are the cause of lysyl hydroxylase 3 deficiency (LH3 deficiency) [MIM:612394]; also known as bone fragility with contractures arterial rupture and deafness. LH3 deficiency is a connective tissue disorder. The syndrome is characterized by congenital malformations severely affecting many tissues and organs and revealing features of several collagen disorders, most of them involving COL2A1 (type II collagen). The findings suggest that the failure of lysyl hydroxylation and hydroxylysyl carbohydrate addition, which affects many collagens, is the molecular basis of this syndrome. -
序列相似性
Contains 1 Fe2OG dioxygenase domain. -
细胞定位
Rough endoplasmic reticulum membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 8985 Human
- Entrez Gene: 26433 Mouse
- Entrez Gene: 288583 Rat
- Omim: 603066 Human
- SwissProt: O60568 Human
- SwissProt: Q9R0E1 Mouse
- SwissProt: Q5U367 Rat
- Unigene: 153357 Human
see all -
别名
- 2-oxoglutarate 5-dioxygenase 3 antibody
- bone protein I antibody
- BP-I antibody
see all
图片
数据表及文件
-
SDS download
-
Datasheet download
文献 (5)
ab128698 被引用在 5 文献中.
- Guo T et al. PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43. Lab Invest 101:564-569 (2021). PubMed: 33483598
- Shi J et al. Integrated Profiling Identifies PLOD3 as a Potential Prognostic and Immunotherapy Relevant Biomarker in Colorectal Cancer. Front Immunol 12:722807 (2021). PubMed: 34646265
- Xie D et al. Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression. Mol Cell Probes 53:101608 (2020). PubMed: 32585183
- Li H et al. Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice. J Cereb Blood Flow Metab 39:547-561 (2019). PubMed: 30516406
- Shao S et al. Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-ß1/Smad3 Signaling Pathway. Med Sci Monit 24:8592-8601 (2018). PubMed: 30481795