Anti-PLGF抗体[RM0010-8F09] (ab51654)
Key features and details
- Rat monoclonal [RM0010-8F09] to PLGF
- Suitable for: WB, IHC-P
- Reacts with: Mouse
- Isotype: IgG2
概述
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产品名称
Anti-PLGF抗体[RM0010-8F09]
参阅全部 PLGF 一抗 -
描述
大鼠单克隆抗体[RM0010-8F09] to PLGF -
宿主
Rat -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse -
免疫原
Recombinant full length protein corresponding to Mouse PLGF.
Database link: P49764 -
阳性对照
- WB: Mouse embryonic tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
纯化说明
ab51654 was produced from a hybridoma. The IgG fraction of the tissue culture supernatant was purified by Protein G affinity chromatography and lyophilized. -
克隆
单克隆 -
克隆编号
RM0010-8F09 -
同种型
IgG2 -
研究领域
相关产品
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Compatible Secondaries
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab51654于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/400 - 1/1000. Predicted molecular weight: 17 kDa.
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IHC-P |
1/50 - 1/100.
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说明 |
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WB
1/400 - 1/1000. Predicted molecular weight: 17 kDa. |
IHC-P
1/50 - 1/100. |
靶标
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功能
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. -
组织特异性
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas. -
序列相似性
Belongs to the PDGF/VEGF growth factor family. -
结构域
Isoform PlGF-2 contains a basic insert which acts as a cell retention signal. -
翻译后修饰
N-glycosylated. -
细胞定位
Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin. - Information by UniProt
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数据库链接
- Entrez Gene: 18654 Mouse
- SwissProt: P49764 Mouse
- Unigene: 4809 Mouse
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别名
- D12S1900 antibody
- Pgf antibody
- PGFL antibody
see all
图片
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Anti-PLGF antibody [RM0010-8F09] (ab51654) at 1/400 dilution + Mouse embryonic tissue lysate
Predicted band size: 17 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLGF antibody [RM0010-8F09] (ab51654)
ab51654 at 1/100 dilution, staining PLGF in LPS exposed mouse lung tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).
数据表及文件
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Datasheet download
文献 (6)
ab51654 被引用在 6 文献中.
- Heiduschka P et al. Different effects of various anti-angiogenic treatments in an experimental mouse model of retinopathy of prematurity. Clin Exp Ophthalmol 47:79-87 (2019). PubMed: 30073769
- Crespo-Garcia S et al. Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO). PLoS One 13:e0193961 (2018). PubMed: 29547662
- Li X et al. Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease. J Cell Mol Med 21:2370-2385 (2017). PubMed: 28378526
- Li Y et al. Folate Deficiency Could Restrain Decidual Angiogenesis in Pregnant Mice. Nutrients 7:6425-45 (2015). WB ; Mouse . PubMed: 26247969
- Saad AF et al. Effects of pravastatin on angiogenic and placental hypoxic imbalance in a mouse model of preeclampsia. Reprod Sci 21:138-45 (2014). Mouse . PubMed: 23749761
- Tayade C et al. Genetic deletion of placenta growth factor in mice alters uterine NK cells. J Immunol 178:4267-75 (2007). IHC-P ; Mouse . PubMed: 17371983