AB127892

Anti-Plexin A4 抗体

Name: Plexin A4抗体 (ab127892)| Abcam中文官网
Brand: Abcam Limited
SKU: AB127892
Price: 4829 CNY
Availability: InStock

Anti-Plexin A4 antibody

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(1 Publication)

Rabbit Polyclonal Plexin A4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PLXNA4 aa 1-250.

查看别名

KIAA1550, PLXNA4A, PLXNA4B, UNQ2820/PRO34003, PLXNA4, Plexin-A4

1 Images

Unknown

Western blot - Anti-Plexin A4 antibody (AB127892)

7.5% SDS Page

All lanes:

Western blot - Anti-Plexin A4 antibody (ab127892) at 1/1000 dilution

All lanes:

293T whole cell lysate at 30 µg

Predicted band size: 212 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Fragment Protein within Human PLXNA4 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q9HCM2

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Plexin A4 also known as PLXNA4 is a protein with a mass of approximately 220 kDa. It functions as a receptor for semaphorin proteins which play an important role in guiding axon pathways during neural development. Plexin A4 binds to its semaphorin ligands and initiates signal transduction resulting in growth cone collapse and axonal growth direction changes. It is highly expressed in the central nervous system particularly in the brain and the spinal cord.

Biological function summary

Plexin A4 facilitates axonal pathfinding and neuronal network formation by interacting with semaphorin ligands and it often functions as part of a receptor complex. The receptor complex typically involves neuropilins which binds to semaphorins with higher affinity and subsequently recruits Plexin A4 for signal transduction. This signaling regulates not only neural development but also plays roles in immune response modulation and vascular development.

Pathways

Plexin A4 engages in semaphorin-plexin signaling and contributes significantly to axonal guidance pathways. It forms part of a signaling cascade with proteins like the neuropilins and other members of the plexin family orchestrating neuronal connectivity. Additionally it interacts with the Rho family of GTPases such as RhoA and Rac1 which are underlying signaling molecules that regulate cytoskeletal dynamics essential for cell migration and morphogenesis.

Disrupted Plexin A4 function associates with neurological conditions like autism spectrum disorders and neurodegenerative diseases. Aberrant Plexin A4 signaling impacts neuronal circuity leading to such disorders. Additionally its involvement in the immune response connects Plexin A4 to autoimmune diseases where dysregulation may contribute to pathogenesis. It often work alongside proteins like semaphorin 3A and neuropilins that are similarly implicated in these disorders.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

See full target information PLXNA4

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 10:1858 PubMed31015415

2019

Excessive miR-25-3p maturation via N-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Jialiang Zhang,Ruihong Bai,Mei Li,Huilin Ye,Chen Wu,Chengfeng Wang,Shengping Li,Liping Tan,Dongmei Mai,Guolin Li,Ling Pan,Yanfen Zheng,Jiachun Su,Ying Ye,Zhiqiang Fu,Shangyou Zheng,Zhixiang Zuo,Zexian Liu,Qi Zhao,Xu Che,Dan Xie,Weihua Jia,Mu-Sheng Zeng,Wen Tan,Rufu Chen,Rui-Hua Xu,Jian Zheng,Dongxin Lin

View all publications

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Abcam Product Promise

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Anti-Plexin A4 抗体

Anti-Plexin A4 antibody

Western blot - Anti-Plexin A4 antibody (AB127892)