AB212383

Anti-Placental alkaline phosphatase (PLAP) 抗体 [ALPP/870] - BSA and Azide free

Name: Placental alkaline phosphatase (PLAP)抗体[ALPP/870] - BSA and Azide free (ab212383)| Abcam中文官网
Brand: Abcam Limited
SKU: AB212383
Price: 9609 CNY
Availability: InStock

Anti-Placental alkaline phosphatase (PLAP) antibody [ALPP/870] - BSA and Azide free

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(3 Publications)

Mouse Monoclonal PPB1 antibody. Carrier free. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ALPP.

查看别名

PLAP, ALPP, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1, PLAP-1

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Placental alkaline phosphatase (PLAP) antibody [ALPP/870] - BSA and Azide free (AB212383)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Placental alkaline phosphatase (PLAP) antibody [ALPP/870] - BSA and Azide free (AB212383)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human placenta tissue section labeling Placental alkaline phosphatase (PLAP) with ab212383 at 0.5 μg/mL.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

ALPP/870

亚型

IgG2b

轻链类型

kappa

不含载体蛋白

Yes

反应种属

Human

应用

IHC-P

applications

免疫原

Recombinant Full Length Protein corresponding to Human ALPP.

P05187

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "notRecommended", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.25-0.5 µg/mL", "IHCP-species-notes": "<p>for 30 minutes at room temperature</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A/G

存储溶液

pH: 7.2 - 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Placental alkaline phosphatase (PLAP) also known by names like alkaline phosphatase/PLAP protein or ALPP functions as an enzyme that removes phosphate groups from molecules. It typically appears in tissues such as the placenta and is known to be active during pregnancy. PLAP has a molecular mass of approximately 66 kDa. Normally found expressed in the placenta this enzyme shares similarities with other alkaline phosphatases but is distinct due to its specific expression and function during gestation.

Biological function summary

PLAP shows importance in bone mineralization and fetal development. It participates in the hydrolysis of phosphate esters influencing nutrient availability and metabolism. PLAP is not a part of major protein complexes; however its enzymatic activity directly affects local phosphate concentrations which are critical for processes like bone formation and tissue regeneration during pregnancy.

Pathways

PLAP expression and activity intersect significantly with phosphate metabolism and fetal development pathways. The alkaline phosphatase family plays central roles in these pathways and PLAP shares functions with other isoenzymes in the family such as the tissue nonspecific alkaline phosphatase. These enzymes regulate phosphate turnover and contribute to essential developmental processes.

PLAP connects primarily to certain types of cancers and gestational disorders. Elevated levels of PLAP link to testicular germ cell tumors and ovarian cancer where it serves as a biomarker. In gestational trophoblastic disease PLAP expression provides valuable diagnostic information. Interactions with proteins like hCG (human chorionic gonadotropin) also offer insights into potential disease mechanisms especially in reproductive health challenges.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Alkaline phosphatase that can hydrolyze various phosphate compounds.

See full target information ALPP

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

iScience 27:110668 PubMed39246442

2024

Multiplex imaging of localized prostate tumors reveals altered spatial organization of AR-positive cells in the microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Çiğdem Ak,Zeynep Sayar,Guillaume Thibault,Erik A Burlingame,M J Kuykendall,Jennifer Eng,Alex Chitsazan,Koei Chin,Andrew C Adey,Christopher Boniface,Paul T Spellman,George V Thomas,Ryan P Kopp,Emek Demir,Young Hwan Chang,Vasilis Stavrinides,Sebnem Ece Eksi

iScience 26:107648 PubMed37670782

2023

Antibody attributes, Fc receptor expression, gestation and maternal SARS-CoV-2 infection modulate HSV IgG placental transfer.

Applications

Unspecified application

Species

Unspecified reactive species

Aakash Mahant Mahant,Fatima Estrada Trejo,Jennifer T Aguilan,Simone Sidoli,Sallie R Permar,Betsy C Herold

Cell 184:628-642.e10 PubMed33476549

2021

Compromised SARS-CoV-2-specific placental antibody transfer.

Applications

Unspecified application

Species

Unspecified reactive species

Caroline Atyeo,Krista M Pullen,Evan A Bordt,Stephanie Fischinger,John Burke,Ashlin Michell,Matthew D Slein,Carolin Loos,Lydia L Shook,Adeline A Boatin,Laura J Yockey,David Pepin,Marie-Charlotte Meinsohn,Ngoc Minh Phuong Nguyen,Maeva Chauvin,Drucilla Roberts,Ilona T Goldfarb,Juan D Matute,Kaitlyn E James,Lael M Yonker,Lisa M Bebell,Anjali J Kaimal,Kathryn J Gray,Douglas Lauffenburger,Andrea G Edlow,Galit Alter

View all publications

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Anti-Placental alkaline phosphatase (PLAP) 抗体 [ALPP/870] - BSA and Azide free

Anti-Placental alkaline phosphatase (PLAP) antibody [ALPP/870] - BSA and Azide free

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Placental alkaline phosphatase (PLAP) antibody [ALPP/870] - BSA and Azide free (AB212383)

关键信息

宿主种属

克隆

克隆号

亚型

轻链类型

不含载体蛋白

反应种属

应用

免疫原