Anti-PLA2G5抗体(ab23709)
Key features and details
- Rabbit polyclonal to PLA2G5
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-PLA2G5抗体 -
描述
兔多克隆抗体to PLA2G5 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide corresponding to Mouse PLA2G5 aa 50-150 conjugated to keyhole limpet haemocyanin.
Database link: P97391 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 50% Glycerol, 0.05% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab23709于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500. Predicted molecular weight: 15 kDa.
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| 说明 |
|---|
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WB
1/500. Predicted molecular weight: 15 kDa. |
靶标
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功能
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle. -
组织特异性
Heart, placenta and less abundantly, in lung. -
序列相似性
Belongs to the phospholipase A2 family. -
翻译后修饰
This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 5322 Human
- Entrez Gene: 18784 Mouse
- Omim: 601192 Human
- SwissProt: P39877 Human
- SwissProt: P97391 Mouse
- Unigene: 319438 Human
- Unigene: 23347 Mouse
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别名
- Ca2+ dependent phospholipase A2 antibody
- Calcium dependent phospholipase A2 antibody
- Calcium-dependent phospholipase A2 antibody
see all
图片
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Western blot - Anti-PLA2G5 antibody (ab23709)All lanes : Anti-PLA2G5 antibody (ab23709) at 1/500 dilution
Lane 1 : Recombinant human sPLA2 (type V) (100 ng)
Lane 2 : Recombinant human sPLA2 (type V) (50 ng)
Lane 3 : Mouse heart homogenate (50ug)
Predicted band size: 15 kDa
Observed band size: 15 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab23709 被引用在 3 文献中.
- Fujioka D et al. Group V Secretory Phospholipase A2 Regulates Endocytosis of Acetylated LDL by Transcriptional Activation of PGK1 in RAW264.7 Macrophage Cell Line. J Atheroscler Thromb 29:692-718 (2022). PubMed: 33775979
- Watanabe K et al. Group V secreted phospholipase A2 plays a protective role against aortic dissection. J Biol Chem 295:10092-10111 (2020). PubMed: 32482892
- Zhu S et al. High-Density Lipoprotein (HDL) Counter-Regulates Serum Amyloid A (SAA)-Induced sPLA2-IIE and sPLA2-V Expression in Macrophages. PLoS One 11:e0167468 (2016). WB ; Mouse . PubMed: 27898742