AB232997

Anti-PI3 Kinase p110 beta抗体

Name: PI3 Kinase p110 beta抗体 (ab232997)| Abcam中文官网
Brand: Abcam Limited
SKU: AB232997
Price: 4748 CNY
Availability: InStock

Anti-PI3 Kinase p110 beta antibody

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(5 Publications)

Rabbit Polyclonal PI3 Kinase p110 beta antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Pig, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PIK3CB aa 800 to C-terminus.

查看别名

PIK3C1, PIK3CB, PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, PtdIns-3-kinase subunit beta, Serine/threonine protein kinase PIK3CB, PtdIns-3-kinase subunit p110-beta, p110beta

9 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PI3 Kinase p110 beta antibody (AB232997)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PI3 Kinase p110 beta antibody (AB232997)

Formalin-fixed, paraffin-embedded human liver tissue stained for PI3 Kinase p110 beta using ab232997 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PI3 Kinase p110 beta antibody (AB232997)

Formalin-fixed, paraffin-embedded human kidney tissue stained for PI3 Kinase p110 beta using ab232997 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Immunocytochemistry/ Immunofluorescence - Anti-PI3 Kinase p110 beta antibody (AB232997)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-PI3 Kinase p110 beta antibody (AB232997)

HepG2 (human liver hepatocellular carcinoma cell line) stained for PI3 Kinase p110 beta (green) at 20 μg/mL in ICC/IF. FITC-labeled secondary antibody.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PI3 Kinase p110 beta antibody (AB232997)

Formalin-fixed, paraffin-embedded human prostate tissue stained for PI3 Kinase p110 beta using ab232997 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PI3 Kinase p110 beta antibody (AB232997)

Formalin-fixed, paraffin-embedded human stomach tissue stained for PI3 Kinase p110 beta using ab232997 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PI3 Kinase p110 beta antibody (AB232997)

Formalin-fixed, paraffin-embedded human liver cancer tissue stained for PI3 Kinase p110 beta using ab232997 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-PI3 Kinase p110 beta antibody (AB232997)

All lanes:

Western blot - Anti-PI3 Kinase p110 beta antibody (ab232997) at 2 µg/mL

All lanes:

Recombinant human PI3 Kinase p110 beta protein

Predicted band size: 123 kDa

false

Supplier Data

Western blot - Anti-PI3 Kinase p110 beta antibody (AB232997)

All lanes:

Western blot - Anti-PI3 Kinase p110 beta antibody (ab232997) at 2 µg/mL

All lanes:

Mouse parotid gland lysate

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit at 1/1000 dilution

Predicted band size: 123 kDa

false

Supplier Data

Western blot - Anti-PI3 Kinase p110 beta antibody (AB232997)

All lanes:

Western blot - Anti-PI3 Kinase p110 beta antibody (ab232997) at 2 µg/mL

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Pig cerebrum lysate

Predicted band size: 123 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Human, Pig

应用

ICC/IF, IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human PIK3CB aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P42338

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "5-20 µg/mL", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

纯化说明

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

存储溶液

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Phosphatidylinositol 3-kinase p110 beta (PI3 kinase p110β) also known as PI3Kβ is an enzyme that belongs to the class I PI3-kinases. It functions as a catalytic subunit in the PI3K complex. The PI3 kinase p110β has a molecular mass of approximately 122 kDa. This protein is expressed in various tissues with notable presence in heart and skeletal muscles. The enzyme is responsible for phosphorylating PIP2 to generate PIP3 an essential step in signaling pathways that regulate cell growth and survival.

Biological function summary

PI3 kinase p110β plays a role in the regulation of cellular processes such as proliferation migration and metabolism. It is a component of the PI3K complex comprised of regulatory and catalytic subunits which form functional homodimers or heterodimers. This complex is activated by various receptors including G-protein coupled receptors (GPCRs) and tyrosine kinase receptors. By converting PIP2 to PIP3 it aids in the recruitment and activation of downstream signaling proteins like AKT.

Pathways

PI3 kinase p110β is integral in the PI3K/AKT signaling pathway and also contributes to the regulation of the mTOR pathway. These pathways are critical for controlling cellular responses to growth signals and maintaining homeostasis. Association with proteins like PTEN which negatively regulates the PI3K/AKT pathway highlights its importance in maintaining cellular balance. PI3 kinase p110β also interacts with other PI3 proteins like p110α showing the intricate network of signaling it participates in.

PI3 kinase p110β has been implicated in cancer and cardiovascular diseases. Its overactivation leads to unchecked cellular proliferation contributing significantly to oncogenesis. Alterations in the PI3K/AKT/mTOR pathway are common in breast cancer highlighting its interaction with proteins such as ERBB2. In cardiovascular disorders PI3 kinase p110β influences heart development and function where it can impact the action of related proteins like PI3 kinase p110α. The study of PI3 kinase p110β in these diseases offers potential for targeted therapies and improved understanding of its pathological roles.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed : 15135396). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed : 15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Also has a protein kinase activity showing autophosphorylation (PubMed : 12502714).

See full target information PIK3CB

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Research (Washington, D.C.) 8:0704 PubMed40416362

2025

Gut Microbiota Modulation by Lysozyme as a Key Regulator of Vascular Inflammatory Aging.

Applications

Unspecified application

Species

Unspecified reactive species

Chenyang Zhang,Xin Zhao,Hang Zhang,Tongtong Wang,Zhenyu Zhang,Yilin Yin,Hui Wang,Xiao Tong,Yuzheng Xue,Yahong Zhou,Fenglai Yuan,Xiuwu Bian,Hong Wei,Yuan Huang,Tianhao Liu

Experimental and therapeutic medicine 23:414 PubMed35601067

2022

Resveratrol protects against atherosclerosis by downregulating the PI3K/AKT/mTOR signaling pathway in atherosclerosis model mice.

Applications

Unspecified application

Species

Unspecified reactive species

Wuguang Ji,Jing Sun,Zonghua Hu,Bo Sun

Journal of clinical medicine 8: PubMed31234342

2019

Analgesic and Antidepressant Effects of Oltipraz on Neuropathic Pain in Mice by Modulating Microglial Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Andrés Felipe Díaz,Sara Polo,Núria Gallardo,Sergi Leánez,Olga Pol

Frontiers in pharmacology 10:283 PubMed30971925

2019

Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Polo,Andrés Felipe Díaz,Núria Gallardo,Sergi Leánez,Gianfranco Balboni,Olga Pol

Oncology letters 17:3439-3445 PubMed30867782

2019

PABPC1L depletion inhibits proliferation and migration via blockage of AKT pathway in human colorectal cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yue-Qin Wu,Chao-Long Ju,Bao-Juan Wang,Ruo-Gu Wang

View all publications

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Anti-PI3 Kinase p110 beta抗体

Anti-PI3 Kinase p110 beta antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PI3 Kinase p110 beta antibody (AB232997)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PI3 Kinase p110 beta antibody (AB232997)

Immunocytochemistry/ Immunofluorescence - Anti-PI3 Kinase p110 beta antibody (AB232997)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PI3 Kinase p110 beta antibody (AB232997)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PI3 Kinase p110 beta antibody (AB232997)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PI3 Kinase p110 beta antibody (AB232997)

Western blot - Anti-PI3 Kinase p110 beta antibody (AB232997)

Western blot - Anti-PI3 Kinase p110 beta antibody (AB232997)

Western blot - Anti-PI3 Kinase p110 beta antibody (AB232997)