Anti-PGP9.5抗体(ab72910)
Key features and details
- Chicken polyclonal to PGP9.5
- Suitable for: WB, ICC/IF
- Reacts with: Rat
- Isotype: IgY
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-PGP9.5抗体
参阅全部 PGP9.5 一抗 -
描述
鸡多克隆抗体to PGP9.5 -
宿主
Chicken -
经测试应用
适用于: WB, ICC/IFmore details -
种属反应性
与反应: Rat -
免疫原
Recombinant full length human PGP9.5 purified from E. coli.
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阳性对照
- Rat hippocampal homogenate and Rat mixed neuron/glial cultures.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.065% Sodium azide -
Concentration information loading... -
纯度
IgY fraction -
克隆
多克隆 -
同种型
IgY -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab72910于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/2500. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa).
|
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| ICC/IF | (1) |
1/500.
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| 说明 |
|---|
|
WB
1/2500. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa). |
|
ICC/IF
1/500. |
靶标
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功能
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. -
组织特异性
Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. -
疾病相关
Parkinson disease 5
Neurodegeneration with optic atrophy, childhood-onset -
序列相似性
Belongs to the peptidase C12 family. -
翻译后修饰
O-glycosylated. -
细胞定位
Cytoplasm. Endoplasmic reticulum membrane. About 30% of total UCHL1 is associated with membranes in brain. - Information by UniProt
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数据库链接
- Entrez Gene: 29545 Rat
- SwissProt: Q00981 Rat
- Unigene: 107213 Rat
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别名
- Epididymis luminal protein 117 antibody
- Epididymis secretory protein Li 53 antibody
- HEL 117 antibody
see all
图片
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Western blot - Anti-PGP9.5 antibody (ab72910)Anti-PGP9.5 antibody (ab72910) at 1/2500 dilution + rat hippocampal homogenate
Predicted band size: 25 kDa
Observed band size: 25 kDa -
Immunocytochemistry/ Immunofluorescence - Anti-PGP9.5 antibody (ab72910)ab72910 at 1/500 dilution staining PGP9.5 in rat mixed neuron/glial cultures by Immunofluorescence (green). Rabbit anti-GFAP antibody (red). Blue is a DNA stain.
实验方案
数据表及文件
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Datasheet download
文献 (9)
ab72910 被引用在 9 文献中.
- Klein I et al. Glycyrrhizic Acid Prevents Paclitaxel-Induced Neuropathy via Inhibition of OATP-Mediated Neuronal Uptake. Cells 12:N/A (2023). PubMed: 37174648
- Gadomski S et al. A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise. Cell Stem Cell 29:528-544.e9 (2022). PubMed: 35276096
- Wong R et al. Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons. Brain Behav Immun N/A:N/A (2018). PubMed: 30453020
- Yu W et al. Role of P2X4Receptor in Mouse Voiding Function. Sci Rep 8:1838 (2018). ICC/IF . PubMed: 29382907
- Chen QQ et al. Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson's disease. Transl Neurodegener 7:13 (2018). PubMed: 29988485
- McQuade RM et al. Irinotecan-Induced Gastrointestinal Dysfunction Is Associated with Enteric Neuropathy, but Increased Numbers of Cholinergic Myenteric Neurons. Front Physiol 8:391 (2017). IHC-P ; Mouse . PubMed: 28642718
- Guan NN et al. Receptors involved in the modulation of guinea pig urinary bladder motility by prostaglandin D2. Br J Pharmacol 172:4024-37 (2015). PubMed: 25917171
- Fu YY et al. 3-D imaging and illustration of mouse intestinal neurovascular complex. Am J Physiol Gastrointest Liver Physiol 304:G1-11 (2013). ICC/IF ; Mouse . PubMed: 23086917
- Allen C et al. Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA. J Immunol 189:381-92 (2012). PubMed: 22661091
