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AB16754

Anti-Peroxiredoxin 4抗体[1A1]

Anti-Peroxiredoxin 4 antibody [1A1]

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(1 Publication)

Mouse Monoclonal Peroxiredoxin 4 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PRDX4.

查看别名

Peroxiredoxin-4, Antioxidant enzyme AOE372, Peroxiredoxin IV, Thioredoxin peroxidase AO372, Thioredoxin-dependent peroxide reductase A0372, Thioredoxin-dependent peroxiredoxin 4, AOE37-2, Prx-IV, PRDX4

2 Images
Immunoprecipitation - Anti-Peroxiredoxin 4 antibody [1A1] (AB16754)
  • IP

Unknown

Immunoprecipitation - Anti-Peroxiredoxin 4 antibody [1A1] (AB16754)

ab16754 at 1.5μg/ml immunoprecipitating Peroxiredoxin 4 from HeLa cell lysate

Lane 1 : Input

Lane 2 : Precipitates

All lanes:

Immunoprecipitation - Anti-Peroxiredoxin 4 antibody [1A1] (ab16754)

Predicted band size: 31 kDa

false

Immunoprecipitation - Anti-Peroxiredoxin 4 antibody [1A1] (AB16754)
  • IP

Supplier Data

Immunoprecipitation - Anti-Peroxiredoxin 4 antibody [1A1] (AB16754)

Ladder M.W(kDa) : 7, 17, 25, 30, 46, 58, 80, 175

All lanes:

Immunoprecipitation - Anti-Peroxiredoxin 4 antibody [1A1] (ab16754) at 1/2000 dilution

Lane 1:

HeLa Cell Lysate

Lane 2:

Precipitated from HeLa Cell Lysate 200ug using ab16754 2ug

Lane 3:

Precipitated from HeLa Cell Lysate 200ug using ab16754 5ug

Lane 4:

Precipitated from PBS using ab16754 5ug

Predicted band size: 31 kDa

false

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

1A1

亚型

IgG3

轻链类型

kappa

不含载体蛋白

No

反应种属

Human

应用

IP

applications

免疫原

Recombinant Fragment Protein within Human PRDX4. The exact immunogen used to generate this antibody is proprietary information.

Q13162

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1-2 µg/mL", "IP-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "1-2 µg/mL", "IP-species-notes": "<p></p>" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "1-2 µg/mL", "IP-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Precipitation Ammonium Sulphate
纯化说明
Purified from TCS
存储溶液
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Peroxiredoxin 4 also known as Prdx4 is a protein that acts as an antioxidant enzyme and belongs to the peroxiredoxin family. It influences the reduction of hydrogen peroxide and organic hydroperoxides. The molecular mass of Prdx4 is approximately 31 kDa. It is expressed mainly in the endoplasmic reticulum but you can find some expression in the cytosol as well.
Biological function summary

Prdx4 plays a list of roles in cellular defense against oxidative stress. It not only reduces peroxides but also contributes to the maintenance of protein folding by modifying disulfide bonds in the endoplasmic reticulum. Prdx4 does not function as part of a larger complex but acts independently within its compartments. The protective functions of Prdx4 are important for cell survival and proper cellular function.

Pathways

Prdx4 interacts with oxidative stress response pathways. Specifically it participates in the redox signaling pathways that regulate cellular reactive oxygen species levels. Peroxiredoxin 4 is closely associated with proteins such as thioredoxin in these pathways. Together they regulate the cellular redox environment which is important for maintaining cellular homeostasis.

Oxidative stress imbalance implicates Prdx4 in conditions like diabetes and cancer. For example in diabetes altered Prdx4 levels disturb normal cell function due to increased oxidative stress. In cancer Prdx4 can influence tumor progression by modulating the antioxidant capacity within cells. Prdx4 also shows a functional connection to proteins like glutathione peroxidase in regulating oxidative stress-related pathologies.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
See full target information PRDX4
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular cell 84:4808-4823.e13 PubMed39667934

2024

CRL3 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Roberta Cacioppo,Alexander Gillis,Iván Shlamovitz,Andrew Zeller,Daniela Castiblanco,Alastair Crisp,Benjamin Haworth,Angela Arabiotorre,Pegah Abyaneh,Yu Bao,Julian E Sale,Scott Berry,Ana Tufegdžić Vidaković
View all publications
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