AB92460

Anti-Periostin抗体

Name: Periostin抗体 (ab92460)| Abcam中文官网
Brand: Abcam Limited
SKU: AB92460
Price: 5165 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-Periostin antibody

(1 Review)

(26 Publications)

Rabbit Polyclonal Periostin antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat, Human, Mouse, Chicken samples. Cited in 26 publications. Immunogen corresponding to Synthetic Peptide within Mouse Postn.

查看别名

OSF2, POSTN, Periostin, PN, Osteoblast-specific factor 2, OSF-2

1 Images

Unknown

Western blot - Anti-Periostin antibody (AB92460)

All lanes:

Western blot - Anti-Periostin antibody (ab92460) at 1/1000 dilution

All lanes:

rat lung lysate

Predicted band size: 93 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat, Chicken, Human, Mouse

应用

ICC/IF, IHC-P, WB

applications

免疫原

Synthetic Peptide within Mouse Postn. The exact immunogen used to generate this antibody is proprietary information.

Q62009

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Amphibian": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Bird": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chicken": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Fish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mammals": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Periostin also known as POSTN or OSF-2 is an extracellular matrix protein with a molecular weight of approximately 90 kDa. It plays a mechanical role in tissue remodeling by binding to integrins which supports tissue repair and regeneration. Periostin is mainly expressed in collagen-rich tissues such as bone periodontal ligament and cardiac tissues. It is synthesized by osteoblasts fibroblasts and other stromal cells functioning as a structural protein that supports cell adhesion and migration.

Biological function summary

The periostin protein contributes to the maintenance of tissue integrity and mechanical properties. It does not solely act; it forms part of a multiprotein complex with collagen and other extracellular matrix components. This involvement is necessary for maintaining cellular interactions and promoting tissue healing processes. Additionally periostin influences cell proliferation and migration impacting developmental and wound healing biology.

Pathways

Periostin is involved in the integrin signaling pathway and the Wnt/β-catenin pathway both important for cell communication and movement. Through these pathways periostin interacts with integrins αvβ3 and αvβ5 facilitating cell adhesion and migration. The Wnt/β-catenin pathway interaction involves several proteins including Frizzled receptors ensuring regulation of cellular proliferation and differentiation. These pathways make periostin a coordinator of complex cellular processes.

The periostin protein is associated with conditions such as fibrotic diseases and cardiovascular disorders. In fibrosis periostin promotes collagen cross-linking exacerbating tissue stiffness. This involves increased interaction with proteins like collagen types I and V contributing to pathological fibrotic progression. In cardiovascular disorders elevated periostin levels after myocardial injury are linked with fibrotic scarring where it collaborates with matrix metalloproteinases to remodel the cardiac tissue architecture. Understanding these connections can lead to novel therapeutic strategies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Induces cell attachment and spreading and plays a role in cell adhesion (PubMed : 12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).

See full target information POSTN

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文献 (26)

Recent publications for all applications. Explore the full list and refine your search

Matrix biology plus 23:100158 PubMed39188294

2024

Proteomic profiling of the extracellular matrix in the human adrenal cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Jean Lucas Kremer,Henrique Sanchez Ortega,Talita Souza-Siqueira,Claudia Blanes Angeli,Leo Kei Iwai,Giuseppe Palmisano,Claudimara Ferini Pacicco Lotfi

Circulation 149:463-474 PubMed37994608

2023

Frequent Premature Atrial Contractions Lead to Adverse Atrial Remodeling and Atrial Fibrillation in a Swine Model.

Applications

Unspecified application

Species

Unspecified reactive species

Satoshi Higuchi,Aleksandr Voskoboinik,Sung Il Im,Adam Lee,Jeffrey Olgin,Ayla Arbil,Junaid Afzal,Gregory M Marcus,Carol Stillson,Dwight Bibby,Theodore Abraham,Emily Wilson,Edward P Gerstenfeld

Pharmacology 108:432-443 PubMed37343534

2023

Quercetin Alleviates Asthma-Induced Airway Inflammation and Remodeling through Downregulating Periostin via Blocking TGF-β1/Smad Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yanni Fang,Wenwen Jin,Zhen Guo,Jumei Hao

Journal of the American Heart Association 12:e025867 PubMed36789858

2023

Cardiac Myocyte-Specific Overexpression of FASTKD1 Prevents Ventricular Rupture After Myocardial Infarction.

Applications

Unspecified application

Species

Unspecified reactive species

Kurt D Marshall,Paula J Klutho,Lihui Song,Rajika Roy,Maike Krenz,Christopher P Baines

Biology 11: PubMed36552348

2022

Differential Expression of Dickkopf 1 and Periostin in Mouse Strains with High and Low Bone Mass.

Applications

Unspecified application

Species

Unspecified reactive species

Katharina Kerschan-Schindl,Victoria Schramek,Maria Butylina,Ursula Föger-Samwald,Peter Pietschmann

American journal of physiology. Heart and circulatory physiology 323:H1376-H1387 PubMed36367690

2022

Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection.

Applications

Unspecified application

Species

Unspecified reactive species

Douglas K Atchison,Christopher L O'Connor,Kimber Converso-Baran,Ingrid L Bergin,Hongyu Zhang,Yu Wang,John R Hartman,Wenjun Ju,Alan V Smrcka,Santhi K Ganesh,Markus Bitzer

Atherosclerosis plus 50:57-64 PubMed36643802

2022

Periostin contributes to the adventitial remodeling of atherosclerosis by activating adventitial fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Zhonghua Wang,Guoliang Li,Mingpeng Li,Lu Hu,Zichen Hao,Qian Li,Chaofeng Sun

Frontiers in immunology 13:1019386 PubMed36311742

2022

Non-invasive measurement of tumor immune microenvironment and prediction of survival and chemotherapeutic benefits from F fluorodeoxyglucose PET/CT images in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Junmeng Li,Chao Zhang,Huihui Guo,Shuang Li,Yang You,Peiming Zheng,Hongquan Zhang,Huanan Wang,Junwei Bai

Oxidative medicine and cellular longevity 2022:8538296 PubMed35387264

2022

Ageing Increases Cardiac Electrical Remodelling in Rats and Mice via NOX4/ROS/CaMKII-Mediated Calcium Signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Xian Luo,Wendie Yu,Zhu Liu,Zhaoli Pu,Ting Liu,Yangpeng Li,Weichao Liu,Ming Lei,Xiaoqiu Tan,Tangting Chen

The American journal of pathology 190:145-157 PubMed31610174

2019

Involvement of Transcription Factor 21 in the Pathogenesis of Fibrosis in Endometriosis.

Applications

Unspecified application

Species

Unspecified reactive species

Umida Ganieva,Tomoko Nakamura,Satoko Osuka, Bayasula,Natsuki Nakanishi,Yukiyo Kasahara,Nobuyoshi Takasaki,Ayako Muraoka,Shotaro Hayashi,Takashi Nagai,Tomohiko Murase,Maki Goto,Akira Iwase,Fumitaka Kikkawa

View all publications

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