AB231130

Anti-Periostin抗体

Name: Periostin抗体 (ab231130)| Abcam中文官网
Brand: Abcam Limited
SKU: AB231130
Price: 4748 CNY
Availability: InStock

Anti-Periostin antibody

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(2 Publications)

Rabbit Polyclonal Periostin antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 2 publications.

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Postn

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody (AB231130)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody (AB231130)

Formalin-fixed, paraffin-embedded rat liver tissue stained for Periostin using ab231130 at 20 μg/ml in immunohistochemical analysis.

Supplier Data

Western blot - Anti-Periostin antibody (AB231130)

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Western blot - Anti-Periostin antibody (ab231130) at 2 µg/mL

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Rat serum

Predicted band size: 93 kDa

true

Supplier Data

Western blot - Anti-Periostin antibody (AB231130)

All lanes:

Western blot - Anti-Periostin antibody (ab231130) at 2 µg/mL

All lanes:

Rat lung tissue lysate.

Predicted band size: 164 kDa,93 kDa

true

Supplier Data

Western blot - Anti-Periostin antibody (AB231130)

All lanes:

Western blot - Anti-Periostin antibody (ab231130) at 2 µg/mL

All lanes:

Recombinant rat Periostin protein.

Predicted band size: 17 kDa,93 kDa

true

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat

应用

IHC-P, WB

applications

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Periostin also known as POSTN or OSF-2 is an extracellular matrix protein with a molecular weight of approximately 90 kDa. It plays a mechanical role in tissue remodeling by binding to integrins which supports tissue repair and regeneration. Periostin is mainly expressed in collagen-rich tissues such as bone periodontal ligament and cardiac tissues. It is synthesized by osteoblasts fibroblasts and other stromal cells functioning as a structural protein that supports cell adhesion and migration.

Biological function summary

The periostin protein contributes to the maintenance of tissue integrity and mechanical properties. It does not solely act; it forms part of a multiprotein complex with collagen and other extracellular matrix components. This involvement is necessary for maintaining cellular interactions and promoting tissue healing processes. Additionally periostin influences cell proliferation and migration impacting developmental and wound healing biology.

Pathways

Periostin is involved in the integrin signaling pathway and the Wnt/β-catenin pathway both important for cell communication and movement. Through these pathways periostin interacts with integrins αvβ3 and αvβ5 facilitating cell adhesion and migration. The Wnt/β-catenin pathway interaction involves several proteins including Frizzled receptors ensuring regulation of cellular proliferation and differentiation. These pathways make periostin a coordinator of complex cellular processes.

The periostin protein is associated with conditions such as fibrotic diseases and cardiovascular disorders. In fibrosis periostin promotes collagen cross-linking exacerbating tissue stiffness. This involves increased interaction with proteins like collagen types I and V contributing to pathological fibrotic progression. In cardiovascular disorders elevated periostin levels after myocardial injury are linked with fibrotic scarring where it collaborates with matrix metalloproteinases to remodel the cardiac tissue architecture. Understanding these connections can lead to novel therapeutic strategies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information Periostin

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e27494 PubMed38515687

2024

Regulation of Dihydroartemisinin on the pathological progression of laryngeal carcinoma through the periostin/YAP/IL-6 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xin-Yu Zhang,Rui-Cong Li,Cong Xu,Xiao-Ming Li

OncoTargets and therapy 13:8299-8311 PubMed32903879

2020

Integrative Analysis of the IQ Motif-Containing GTPase-Activating Protein Family Indicates That the IQGAP3-PIK3C2B Axis Promotes Invasion in Colon Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zhuo Liu,Xiao Li,Jie Ma,Dechuan Li,Haixing Ju,Yong Liu,Yinbo Chen,Xujun He,Yuping Zhu

View all publications

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Anti-Periostin抗体

Anti-Periostin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody (AB231130)

Western blot - Anti-Periostin antibody (AB231130)

Western blot - Anti-Periostin antibody (AB231130)

Western blot - Anti-Periostin antibody (AB231130)