AB152099

Anti-Periostin抗体

Name: Periostin抗体 (ab152099)| Abcam中文官网
Brand: Abcam Limited
SKU: AB152099
Price: 5144 CNY
Availability: InStock

Anti-Periostin antibody

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(6 Publications)

Rabbit Polyclonal Periostin antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human POSTN aa 600 to C-terminus.

查看别名

OSF2, POSTN, Periostin, PN, Osteoblast-specific factor 2, OSF-2

6 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody (AB152099)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody (AB152099)

Immunohistochemical analysis of paraffin-embedded Human gastric tissue labeling Periostin with ab152099 at 1/100 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-Periostin antibody (AB152099)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Periostin antibody (AB152099)

Immunofluorescent analysis of paraformaldehyde-fixed HeLa cells labeling Periostin with ab152099 at 1/200. Lower image is merged with DNA probe.

Unknown

Western blot - Anti-Periostin antibody (AB152099)

7.5% SDS PAGE

All lanes:

Western blot - Anti-Periostin antibody (ab152099) at 1/1000 dilution

All lanes:

H1299 whole cell lysate at 30 µg

Predicted band size: 93 kDa

false

Supplier Data

Western blot - Anti-Periostin antibody (AB152099)

Samples were separated by 7.5% SDS-PAGE.

All lanes:

Western blot - Anti-Periostin antibody (ab152099) at 1/1000 dilution

Lane 1:

HeLa whole cell extracts at 30 µg

Lane 2:

SK-N-SH whole cell extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG

Observed band size: 90 kDa

false

Supplier Data

Western blot - Anti-Periostin antibody (AB152099)

Samples were separated by 7.5% SDS-PAGE.

All lanes:

Western blot - Anti-Periostin antibody (ab152099) at 1/1000 dilution

Lane 1:

HeLa whole cell extracts at 30 µg

Lane 2:

SK-N-SH whole cell extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG

Observed band size: 90 kDa

false

Supplier Data

Western blot - Anti-Periostin antibody (AB152099)

Samples were separated by 7.5% SDS-PAGE.

All lanes:

Western blot - Anti-Periostin antibody (ab152099) at 1/4000 dilution

Lane 1:

Non-transfected HeLa whole cell extracts at 30 µg

Lane 2:

Transfected HeLa whole cell extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG

Observed band size: 90 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human, Mouse

应用

ICC/IF, WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human POSTN aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q15063

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Periostin also known as POSTN or OSF-2 is an extracellular matrix protein with a molecular weight of approximately 90 kDa. It plays a mechanical role in tissue remodeling by binding to integrins which supports tissue repair and regeneration. Periostin is mainly expressed in collagen-rich tissues such as bone periodontal ligament and cardiac tissues. It is synthesized by osteoblasts fibroblasts and other stromal cells functioning as a structural protein that supports cell adhesion and migration.

Biological function summary

The periostin protein contributes to the maintenance of tissue integrity and mechanical properties. It does not solely act; it forms part of a multiprotein complex with collagen and other extracellular matrix components. This involvement is necessary for maintaining cellular interactions and promoting tissue healing processes. Additionally periostin influences cell proliferation and migration impacting developmental and wound healing biology.

Pathways

Periostin is involved in the integrin signaling pathway and the Wnt/β-catenin pathway both important for cell communication and movement. Through these pathways periostin interacts with integrins αvβ3 and αvβ5 facilitating cell adhesion and migration. The Wnt/β-catenin pathway interaction involves several proteins including Frizzled receptors ensuring regulation of cellular proliferation and differentiation. These pathways make periostin a coordinator of complex cellular processes.

The periostin protein is associated with conditions such as fibrotic diseases and cardiovascular disorders. In fibrosis periostin promotes collagen cross-linking exacerbating tissue stiffness. This involves increased interaction with proteins like collagen types I and V contributing to pathological fibrotic progression. In cardiovascular disorders elevated periostin levels after myocardial injury are linked with fibrotic scarring where it collaborates with matrix metalloproteinases to remodel the cardiac tissue architecture. Understanding these connections can lead to novel therapeutic strategies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Induces cell attachment and spreading and plays a role in cell adhesion (PubMed : 12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).

See full target information POSTN

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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 16:1596746 PubMed40607434

2025

Inflammation-driven periostin in ECRS has contrasting effects on tissue structural integrity and osteitis.

Applications

Unspecified application

Species

Unspecified reactive species

Soo-In Kim,Min-Seok Rha,Jinsun Kim,Sang Hyeon Ahn,Ji-Hwan Ryu,Hyung-Ju Cho,Chang-Hoon Kim

Acta biochimica et biophysica Sinica 57:1312-1324 PubMed39935324

2025

Proline/serine-rich coiled-coil protein 1 alleviates pyroptosis in murine bone marrow-derived macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Qiao Wu,Qianqian Wang,Kexin Hu,Tiantian Luo,Jichen Liu,Yazhi Xue,Ling Li,Cuiqi Yang,Rongzhan Lin,Hangyu Pan,Jinhao Wang,Zhigang Guo

Nature communications 15:2595 PubMed38519500

2024

Single cell deciphering of progression trajectories of the tumor ecosystem in head and neck cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Z L Liu,X Y Meng,R J Bao,M Y Shen,J J Sun,W D Chen,F Liu,Y He

Journal of asthma and allergy 14:1307-1321 PubMed34744440

2021

Integrative Analysis Reveals a miRNA-mRNA Regulatory Network and Potential Causative Agents in the Asthmatic Airway Epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Jintao Zhang,Zihan Wang,Dong Zhang,Yun Pan,Xiaofei Liu,Xinrui Qiao,Wenjing Cui,Liang Dong

Free radical research :1-19 PubMed33557626

2021

Growth differentiation factor 11 mitigates cardiac radiotoxicity via activating AMPKα.

Applications

Unspecified application

Species

Unspecified reactive species

Xia Li,Dong Ding,Wei Chen,Yu Liu,Haisong Pan,Jun Hu

Aging and disease 9:1043-1057 PubMed30574417

2018

A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Wen Huang,Ming-Fu Chiang,Che-Sheng Ho,Pi-Lien Hung,Mei-Hsin Hsu,Tsung-Han Lee,Lichieh Julie Chu,Hsuan Liu,Petrus Tang,Wailap Victor Ng,Dar-Shong Lin

View all publications

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Anti-Periostin抗体

Anti-Periostin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody (AB152099)

Immunocytochemistry/ Immunofluorescence - Anti-Periostin antibody (AB152099)

Western blot - Anti-Periostin antibody (AB152099)

Western blot - Anti-Periostin antibody (AB152099)

Western blot - Anti-Periostin antibody (AB152099)

Western blot - Anti-Periostin antibody (AB152099)