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AB14041

Anti-Periostin 抗体

Anti-Periostin antibody

5

(20 Reviews)

|

(212 Publications)

Anti-Periostin antibody (ab14041) is a rabbit polyclonal antibody detecting Periostin in IHC-P, IHC-Fr, ICC/IF, ELISA. Suitable for Chicken, Human, Mouse, Rat.

- Over 210 publications
- Trusted since 2004

查看别名

OSF2, POSTN, Periostin, PN, Osteoblast-specific factor 2, OSF-2

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody (AB14041)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody (AB14041)

Immunohistochemistry analysis of formalin-fixed paraffin-embedded human colon tissue section labeling Periostin with ab14041.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody (AB14041)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody (AB14041)

Immunohistochemistry analysis of formalin-fixed paraffin-embedded human normal skin tissue section labeling Periostin with ab14041.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody (AB14041)
  • IHC-P

PubMed

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody (AB14041)

The periostin staining in prostate cancer and paired non-tumorous prostate tissues (TMA from JHU, 140 cases).

(A) The pathologists' criteria for IHC scoring.(a) 0, undetectable; (b)1+, weak staining; (c) 2+, medium staining; (d) 3+, strong staining. Periostin was mainly stained in peritumoral stroma.

Tian et al. PLoS One. 2015 Mar 17;10(3):e0121502. doi: 10.1371/journal.pone.0121502. eCollection 2015. Fig 1. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

Immunocytochemistry/ Immunofluorescence - Anti-Periostin antibody (AB14041)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Periostin antibody (AB14041)

ICC/IF image of ab14041 stained HeLa (Human epithelial cell line from cervix adenocarcinoma) cells.

The cells were fixed in 100% methanol (5 min) and then incubated in 1% BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilize the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab14041, 1/1000 dilution) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43μM.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human, Chicken, Mouse, Rat

应用

IHC-P, IHC-Fr, ELISA, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human POSTN aa 1-700. The exact immunogen used to generate this antibody is proprietary information.

Q15063

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Rat": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Chicken": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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您是否考虑以下替代产品？

AB215199

Anti-Periostin antibody [EPR20806]

0
0 Reviews
查看产品
为什么推荐这个？

为向您提供最高品质的产品，我们在不断升级产品范围。我们选择了这个替代产品供您参考，因为它提供了更好的性能，更容易和更方便的使用，或交期更快。

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产品详情

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
Constituents: PBS, 0.58% Sodium chloride
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Periostin also known as POSTN or OSF-2 is an extracellular matrix protein with a molecular weight of approximately 90 kDa. It plays a mechanical role in tissue remodeling by binding to integrins which supports tissue repair and regeneration. Periostin is mainly expressed in collagen-rich tissues such as bone periodontal ligament and cardiac tissues. It is synthesized by osteoblasts fibroblasts and other stromal cells functioning as a structural protein that supports cell adhesion and migration.
Biological function summary

The periostin protein contributes to the maintenance of tissue integrity and mechanical properties. It does not solely act; it forms part of a multiprotein complex with collagen and other extracellular matrix components. This involvement is necessary for maintaining cellular interactions and promoting tissue healing processes. Additionally periostin influences cell proliferation and migration impacting developmental and wound healing biology.

Pathways

Periostin is involved in the integrin signaling pathway and the Wnt/β-catenin pathway both important for cell communication and movement. Through these pathways periostin interacts with integrins αvβ3 and αvβ5 facilitating cell adhesion and migration. The Wnt/β-catenin pathway interaction involves several proteins including Frizzled receptors ensuring regulation of cellular proliferation and differentiation. These pathways make periostin a coordinator of complex cellular processes.

The periostin protein is associated with conditions such as fibrotic diseases and cardiovascular disorders. In fibrosis periostin promotes collagen cross-linking exacerbating tissue stiffness. This involves increased interaction with proteins like collagen types I and V contributing to pathological fibrotic progression. In cardiovascular disorders elevated periostin levels after myocardial injury are linked with fibrotic scarring where it collaborates with matrix metalloproteinases to remodel the cardiac tissue architecture. Understanding these connections can lead to novel therapeutic strategies.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Induces cell attachment and spreading and plays a role in cell adhesion (PubMed : 12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).
See full target information POSTN
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文献 (212)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed37511063

2023

Chronological Changes in the Expression and Localization of Sox9 between Achilles Tendon Injury and Functional Recovery in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Genji Watanabe,Masahito Yamamoto,Shuichirou Taniguchi,Yuki Sugiyama,Hidetomo Hirouchi,Satoshi Ishizuka,Kei Kitamura,Toshihide Mizoguchi,Takashi Takayama,Katsuhiko Hayashi,Shinichi Abe

International journal of molecular sciences 24: PubMed37298695

2023

Influence of Occlusal Hypofunction on Alveolar Bone Healing in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Damanaki,Svenja Beisel-Memmert,Marjan Nokhbehsaim,Ali Abedi,Birgit Rath-Deschner,Andressa V B Nogueira,James Deschner

Acta dermato-venereologica 103:adv4463 PubMed36967545

2023

Neuroimmune Mediators of Pruritus in Hispanic Scalp Psoriatic Itch.

Applications

Unspecified application

Species

Unspecified reactive species

Leigh A Nattkemper,Zoe M Lipman,Giuseppe Ingrasci,Claudia Maldonado,Juan Carlos Garces,Enrique Loayza,Gil Yosipovitch

The Journal of biological chemistry 299:103031 PubMed36805334

2023

ER stress induces upregulation of transcription factor Tbx20 and downstream Bmp2 signaling to promote cardiomyocyte survival.

Applications

Unspecified application

Species

Unspecified reactive species

Shreya Das,Arunima Mondal,Chandrani Dey,Santanu Chakraborty,Rudranil Bhowmik,Sanmoy Karmakar,Arunima Sengupta

Cells 12: PubMed36831214

2023

Dual Targeting of EGFR and MTOR Pathways Inhibits Glioblastoma Growth by Modulating the Tumor Microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Maxim Sidorov,Pratiksha Dighe,Rinette W L Woo,Aida Rodriguez-Brotons,Michelle Chen,Ryan J Ice,Edith Vaquero,Damon Jian,Pierre-Yves Desprez,Mehdi Nosrati,Leah Galvez,Lewis Leng,Lawrence Dickinson,Mohammed Kashani-Sabet,Sean David McAllister,Liliana Soroceanu

Cancer medicine 12:8510-8525 PubMed36691359

2023

Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Shao Wenhua,Takaaki Tsunematsu,Masaaki Umeda,Hiroaki Tawara,Natsumi Fujiwara,Yasuhiro Mouri,Rieko Arakaki,Naozumi Ishimaru,Yasusei Kudo

The Journal of dermatology 50:927-930 PubMed36651089

2023

IL-31 and IL-31 receptor alpha in pemphigus: Contributors to more than just itch?

Applications

Unspecified application

Species

Unspecified reactive species

Satoshi Okuno,Takashi Hashimoto,Yuki Yamazaki,Manami Okuzawa,Takahiro Satoh

JCI insight 7: PubMed36278481

2022

NOX4 inhibition promotes the remodeling of dystrophic muscle.

Applications

Unspecified application

Species

Unspecified reactive species

David W Hammers

Frontiers in immunology 13:956691 PubMed36341422

2022

Role of periostin in inflammatory bowel disease development and synergistic effects mediated by the CCL5-CCR5 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Saida Mukanova,Anton Borissenko,Alexey Kim,Aigerim Bolatbek,Ainur Abdrakhmanova,Luca Vangelista,Eva Sonnenberg-Riethmacher,Dieter Riethmacher

Atherosclerosis plus 50:57-64 PubMed36643802

2022

Periostin contributes to the adventitial remodeling of atherosclerosis by activating adventitial fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Zhonghua Wang,Guoliang Li,Mingpeng Li,Lu Hu,Zichen Hao,Qian Li,Chaofeng Sun
View all publications
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我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
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