AB172907

重组Anti-Perilipin-1抗体[EPR3753(2)]

Name: Perilipin-1抗体[EPR3753(2)] (ab172907)| Abcam中文官网
Brand: Abcam Limited
SKU: AB172907
Price: 1515 CNY
Availability: InStock
Rating: 5 (4 reviews)

Anti-Perilipin-1 antibody [EPR3753(2)]

20ul selling size
RabMAb
Recombinant
了解详情

(4 Reviews)

(18 Publications)

Rabbit Recombinant Monoclonal Perilipin-1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 18 publications.

查看别名

PERI, PLIN, PLIN1, Perilipin-1, Lipid droplet-associated protein

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-Perilipin-1 antibody [EPR3753(2)] (AB172907)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Perilipin-1 antibody [EPR3753(2)] (AB172907)

Immunofluorescent analysis of HepG2 cells labeling Perilipin-1 with ab172907 at 1/100 (red) and counterstained with DAPI (blue).

Supplier Data

Western blot - Anti-Perilipin-1 antibody [EPR3753(2)] (AB172907)

Lane 1:

Western blot - Anti-Perilipin-1 antibody [EPR3753(2)] (ab172907) at 1/2000 dilution

Lanes 2 - 3:

Western blot - Anti-Perilipin-1 antibody [EPR3753(2)] (ab172907) at 1/10000 dilution

Lane 1:

Fetal heart tissue lysate at 10 µg

Lane 2:

Human adipose tissue lysate at 10 µg

Lane 3:

Fetal liver tissue lysate at 10 µg

Predicted band size: 56 kDa

false

不同偶联物与剂型 (2)

Carrier free

Anti-Perilipin-1 antibody [EPR3753(2)] - BSA and Azide free
519 Alexa Fluor® 488

Alexa Fluor® 488 Anti-Perilipin-1 antibody [EPR3753(2)]

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR3753(2)

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

style

left-column

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/250", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "1/100 - 1/250", "ICCIF-species-notes": "" } } }

style

left-column

产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Conditional Ambient

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Perilipin-1 also known as PLIN1 is a protein with a mass of approximately 57 kDa. It plays an important role in lipid metabolism within adipose tissue. This protein is mainly found in adipocytes where it coats lipid droplets. By controlling the access of lipases to the lipid core Perilipin-1 regulates lipolysis. It prevents unnecessary breakdown of lipids by acting as a barrier and ensuring the protection and storage of energy reserves. This targeted regulation is important for maintaining energy homeostasis in the body.

Biological function summary

Perilipin-1 influences cellular energy balance and fat storage. It is an important member of the PAT family of proteins which includes perilipin A. Perilipin-1 does not typically form part of a larger protein complex; however it works closely with other proteins on the surface of lipid droplets. Its presence on the droplet surface is essential for controlling lipid mobilization particularly during fasting or energy-deprived states when organisms require a mechanism to access stored energy efficiently.

Pathways

The activity of Perilipin-1 is important in the lipolytic pathway. This pathway is involved in hydrolyzing stored triglycerides into free fatty acids and glycerol an essential process in energy metabolism. Perilipin-1 acts in tandem with hormone-sensitive lipase (HSL) to regulate this pathway. Upon activation by adrenaline or other stimuli perilipin-1 undergoes phosphorylation which in turn facilitates HSL translocation to the lipid droplet and enhances lipolysis. Besides its direct role Perilipin-1 also interacts with adipose triglyceride lipase (ATGL) further impacting lipid breakdown processes.

The dysfunction of Perilipin-1 can lead to metabolic diseases like obesity and type 2 diabetes. Abnormal regulation or mutations in the Perilipin-1 gene have been observed in these conditions affecting normal lipid metabolism. Disordered Perilipin-1 function can lead to excessive lipid storage impaired energy mobilization and increased insulin resistance. Additionally Perilipin-1 interacts indirectly with other proteins such as perilipin-2 which can also influence the development of these metabolic disorders. Understanding these interactions helps in exploring therapeutic strategies aimed at targeting lipid metabolism and related diseases.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.

See full target information PLIN1

style

left-column

文献 (18)

Recent publications for all applications. Explore the full list and refine your search

NPJ science of food 9:99 PubMed40500274

2025

Curcumin alleviates visceral adiposity via inhibiting GIP release from hypoxic intestinal damage in MASH rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yingyi Liao,Xingyu Xie,Zixin Lin,Ning Huang,Guilan Wei,Jiazhen Wu,Yucui Li,Jiannan Chen,Ziren Su,Xiuting Yu,Liping Chen,Yuhong Liu

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2417326 PubMed39996504

2025

Lipid Droplets Metabolism Mediated by ANXA7-PPARγ Signaling Axis Regulates Spinal Cord Injury Repair in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Chen,Haoran Liu,Linlin Jiang,Zihang Wang,Yong Chang,Na Li,Shiqing Feng

Journal of cachexia, sarcopenia and muscle 16:e13734 PubMed39971710

2025

SIRT6 Ameliorates Cancer Cachexia-Associated Adipose Wasting by Suppressing TNFR2 Signalling in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Kang Xu,Yida Wang,Fang Wang,Yannan Guo,Yu Ren,Vivien Low,Sungyun Cho,Qingfei Liu,Ying Qiu,Xue Li,Kang Yu,Zhongchi Li,Zhao Wang

Nature communications 15:4827 PubMed38844451

2024

Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Hongdong Wang,Yanhua Du,Shanshan Huang,Xitai Sun,Youqiong Ye,Haixiang Sun,Xuehui Chu,Xiaodong Shan,Yue Yuan,Lei Shen,Yan Bi

The Journal of biological chemistry 300:107319 PubMed38677512

2024

Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation.

Applications

Unspecified application

Species

Unspecified reactive species

Jingwen Pei,Dayuan Zou,Lu Li,Lulu Kang,Minli Sun,Xu Li,Qianyue Chen,Danning Chen,Bin Qu,Xiang Gao,Zhaoyu Lin

Cell and tissue research 396:329-342 PubMed38411945

2024

Exosomes from adipose-derived stem cells activate sebocytes through the PI3K/AKT/SREBP-1 pathway to accelerate wound healing.

Applications

Unspecified application

Species

Unspecified reactive species

Yingbo Zhang,Christos C Zouboulis,Zhibo Xiao

Nature communications 14:2698 PubMed37164963

2023

Viral subversion of selective autophagy is critical for biogenesis of virus replication organelles.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Lan,Sophie Wilhelmina van Leur,Julia Ayano Fernando,Ho Him Wong,Martin Kampmann,Lewis Siu,Jingshu Zhang,Mingyuan Li,John M Nicholls,Sumana Sanyal

Journal of experimental & clinical cancer research : CR 41:129 PubMed35392966

2022

Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Feikai Lin,Xiaoduan Li,Xinjing Wang,Huizhen Sun,Ziliang Wang,Xipeng Wang

Journal of cellular and molecular medicine 26:3153-3168 PubMed35322540

2022

LRG-1 promotes fat graft survival through the RAB31-mediated inhibition of hypoxia-induced apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Chia-Kang Ho,Danning Zheng,Jiaming Sun,Dongsheng Wen,Shan Wu,Li Yu,Ya Gao,Yifan Zhang,Qingfeng Li

Journal of lipid research 63:100194 PubMed35283217

2022

Hormone-sensitive lipase protects adipose triglyceride lipase-deficient mice from lethal lipotoxic cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Mika Yamada,Jinya Suzuki,Satsuki Sato,Yasuo Zenimaru,Rie Saito,Tadashi Konoshita,Fredric B Kraemer,Tamotsu Ishizuka

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-Perilipin-1抗体[EPR3753(2)]