AB234281

PerCP荧光Anti-Syndecan-1抗体[MI15]

Name: PerCP Anti-Syndecan-1抗体[MI15] (ab234281)| Abcam中文官网
Brand: Abcam Limited
SKU: AB234281
Price: 3185 CNY
Availability: InStock

PerCP Anti-Syndecan-1 antibody [MI15]

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(1 Publication)

Mouse Monoclonal Syndecan-1 antibody - conjugated to PerCP. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing SDC1 protein.

查看别名

CD138, SDC, SDC1, Syndecan-1, SYND1

1 Images

Flow Cytometry - PerCP Anti-Syndecan-1 antibody [MI15] (AB234281)

Flow Cyt

Supplier Data

Flow Cytometry - PerCP Anti-Syndecan-1 antibody [MI15] (AB234281)

Surface staining of human peripheral blood for Syndecan-1 using ab234281 at 10 μl/10⁶ cells. Leukocyte + monocyte gate.

不同偶联物与剂型 (3)

Unconjugated

Anti-Syndecan-1 antibody [MI15]
519 FITC

FITC Anti-Syndecan-1 antibody [MI15]
578 PE

PE Anti-Syndecan-1 antibody [MI15]

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

MI15

亚型

IgG1

偶联物

PerCP

激发波长/发射波长

Ex: 490nm, Em: 675nm

不含载体蛋白

反应种属

Human

应用

Flow Cyt

applications

免疫原

Cell preparation containing SDC1 protein. The exact immunogen used to generate this antibody is proprietary information.

P18827

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" }, "Primates": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Size-exclusion chromatography

纯化说明

The purified antibody is conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

存储溶液

pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS

运输条件

Blue Ice

储存信息

Do Not Freeze|Store in the dark

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Syndecan-1 also known as CD138 is a transmembrane heparan sulfate proteoglycan with a molecular weight of approximately 30 to 80 kDa. The size variation arises from differences in its glycosaminoglycan chains. This protein resides predominantly on the surface of epithelial cells and plasma cells. Researchers commonly use the CD138 marker to identify these cells in biological samples. It plays a significant role in cell-cell and cell-matrix interactions acting as a co-receptor for a variety of growth factors cytokines and extracellular matrix proteins.

Biological function summary

Syndecan-1 participates in tissue repair inflammation and cell signaling ensuring epithelial integrity and communication. Syndecan-1 influences cell behavior by interacting with other components of the extracellular matrix and different membrane receptors. It is also involved in forming and regulating proteoglycan complexes at the cell surface. These complex interactions facilitate the modulation of cell proliferation migration and differentiation which are fundamental to maintaining tissue architecture and function.

Pathways

Syndecan-1 actively contributes to both the Wnt and FGF signaling pathways. Through its interaction with proteins such as miR-15 syndecan-1 modulates cellular responses essential for developmental processes and tissue homeostasis. The connection with these pathways allows syndecan-1 to integrate and relay extracellular signals impacting gene expression and cellular behavior. Its relationship with other proteins like A38 as a co-receptor emphasizes its role in finely tuning signaling cascades within cellular environments.

Syndecan-1 shows a connection to multiple myeloma and breast cancer. The overexpression of syndecan-1 in these conditions disrupts normal cellular functions and promotes tumorigenesis by aiding in the tumor cell's adhesion migration and invasion. Its interaction with proteins such as perCP further demonstrates its role in disease progression providing potential as a therapeutic target. These relationships make syndecan-1 an important focus for research in oncology and other fields of disease study.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed : 22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity).

See full target information SDC1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e36483 PubMed39253182

2024

Navitoclax safety, tolerability, and effect on biomarkers of senescence and neurodegeneration in aged nonhuman primates.

Applications

Unspecified application

Species

Unspecified reactive species

Edward F Greenberg,Martin J Voorbach,Alexandra Smith,David R Reuter,Yuchuan Zhuang,Ji-Quan Wang,Dustin W Wooten,Elizabeth Asque,Min Hu,Carolin Hoft,Ryan Duggan,Matthew Townsend,Karin Orsi,Karen Dalecki,Willi Amberg,Lori Duggan,Heather Knight,Joseph S Spina,Yupeng He,Kennan Marsh,Vivian Zhao,Suzanne Ybarra,Jennifer Mollon,Yuni Fang,Aparna Vasanthakumar,Susan Westmoreland,Mathias Droescher,Sjoerd J Finnema,Hana Florian

View all publications

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Abcam Product Promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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PerCP荧光Anti-Syndecan-1抗体[MI15]