AB210252

PerCP荧光/Cy5.5® Anti-F4/80抗体[BM8.1]

Name: PerCP/Cy5.5® Anti-F4/80抗体[BM8.1] (ab210252)| Abcam中文官网
Brand: Abcam Limited
SKU: AB210252
Price: 4748 CNY
Availability: InStock

PerCP/Cy5.5® Anti-F4/80 antibody [BM8.1]

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(2 Publications)

Rat Monoclonal F4/80 antibody - conjugated to PerCP/Cy5.5®. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 2 publications.

查看别名

EMR1, TM7LN3, ADGRE1, Adhesion G protein-coupled receptor E1, EGF-like module receptor 1, EGF-like module-containing mucin-like hormone receptor-like 1, EMR1 hormone receptor

1 Images

Flow Cytometry - PerCP/Cy5.5® Anti-F4/80 antibody [BM8.1] (AB210252)

Flow Cyt

Supplier Data

Flow Cytometry - PerCP/Cy5.5® Anti-F4/80 antibody [BM8.1] (AB210252)

Flow Cytometrical analysis of C57BI/6 bone marrow labeling F4/80 using 0.125 μg ab210252 (right panel) or 0.125 μg PerCP-Cy5.5 Rat IgG2a isotype control (left panel).

关键信息

宿主种属

Rat

克隆

Monoclonal

克隆号

BM8.1

亚型

IgG2a

轻链类型

kappa

偶联物

PerCP/Cy5.5®

激发波长/发射波长

Ex: 482nm, Em: 695nm

不含载体蛋白

反应种属

Mouse

应用

Flow Cyt

applications

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification

纯化说明

Purified from tissue culture supernatant and conjugated under optimal conditions, with unreacted dye removed from the preparation.

存储溶液

pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.12% Sodium dihydrogen phosphate, 0.1% Gelatin

运输条件

Blue Ice

储存信息

Store in the dark

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

F4/80 also known as Emr1 (Epidermal growth factor module-containing mucin-like hormone receptor 1) is a well-characterized surface protein with a mass of approximately 160 kDa. This protein is recognized as a marker for murine macrophages. F4/80 is heavily expressed on cells of the monocyte and macrophage lineage particularly in tissue-resident macrophages found in organs like the liver spleen and lung. Its expression is vital for identifying macrophages in various types of immunological studies including F4/80 staining and macrophage marker analysis.

Biological function summary

F4/80 plays a role in modulating the immune response by interacting with other cell surface molecules. While not part of a larger protein complex F4/80 influences macrophage functions such as phagocytosis and cytokine production. Its expression contributes to the regulation of tissue homeostasis and inflammation. The protein is critical in maintaining the macrophage population required for reliable immune surveillance and response to pathogens.

Pathways

F4/80 is an integral part of the immunological and inflammatory signaling pathways. It interacts with TLRs (Toll-like receptors) and other cell surface molecules that sense microbial components therefore helping in the initiation of innate immune responses. F4/80 is connected to proteins like cytokine receptors which play roles in mediating and resolving inflammatory signals important for maintaining balanced immune activity.

F4/80 is associated with conditions like chronic inflammation and autoimmune disorders. Its expression levels can often correlate with disease state impacting diseases such as rheumatoid arthritis and liver fibrosis. In these conditions F4/80 interacts with proteins like TNF-alpha and IL-1beta which are involved in inflammatory processes. Understanding F4/80's role can help uncover therapeutic targets aimed at modulating macrophage functions to treat these disorders effectively.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.

See full target information ADGRE1

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of pharmaceutical analysis 15:101251 PubMed40521370

2025

Impact of FASN-enriched EVs on endothelial cell function in obstructive sleep apnea hypopnea syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Tian,Dan Zhang,Huaian Yang,Xiaoli Zhang,Shengqun Xu

PloS one 10:e0137835 PubMed26376185

2015

In Situ Characterization of Splenic Brucella melitensis Reservoir Cells during the Chronic Phase of Infection in Susceptible Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Delphine Hanot Mambres,Arnaud Machelart,Jean-Marie Vanderwinden,Carl De Trez,Bernhard Ryffel,Jean-Jacques Letesson,Eric Muraille

View all publications

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PerCP荧光/Cy5.5® Anti-F4/80抗体[BM8.1]

PerCP/Cy5.5® Anti-F4/80 antibody [BM8.1]

Flow Cytometry - PerCP/Cy5.5® Anti-F4/80 antibody [BM8.1] (AB210252)

关键信息

宿主种属

克隆

克隆号

亚型

轻链类型

偶联物

激发波长/发射波长

不含载体蛋白

反应种属

应用