AB322455

PE Anti-Sialoadhesin/CD169 antibody [EPR27102-11]

Recombinant
RabMAb
了解详情

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Rabbit Recombinant Monoclonal Sialoadhesin/CD169 antibody - conjugated to PE. Suitable for Flow Cyt, ICC/IF, IHC-P and reacts with Mouse, Rat samples.

CD169, Sa, Sn, Siglec1, Sialoadhesin, Sheep erythrocyte receptor, Sialic acid-binding Ig-like lectin 1, SER, Siglec-1

2 Images

Flow Cytometry - PE Anti-Sialoadhesin/CD169 antibody [EPR27102-11] (AB322455)

Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-Sialoadhesin/CD169 antibody [EPR27102-11] (AB322455)

Flow cytometric analysis of Mouse bone marrow cells cells labelling Sialoadhesin/CD169 with ab322455 at 1/5000 dilution (0.01ug) / Right compared with a Rabbit IgG monoclonal [EPR25A] - Isotype Control (Phycoerythrin) (ab209478) / Left isotype control and an unlabelled control (cells without incubation with primary antibody and secondary antibody).

Mouse bone marrow cells are co-stained with F4/80 conjugated Alexa Fluor®647.
Gated on viable cell.

Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-Sialoadhesin/CD169 antibody [EPR27102-11] (AB322455)

Mouse bone marrow cells are co-stained with CD3 conjugated Alexa Fluor®647.
Gated on viable cell.

不同偶联物与剂型 (6)

Carrier free

Anti-Sialoadhesin/CD169 antibody [EPR27102-11] - BSA and Azide free
Unconjugated

Anti-Sialoadhesin/CD169 antibody [EPR27102-11]
660 APC

APC Anti-Sialoadhesin/CD169 antibody [EPR27102-11]
519 Alexa Fluor® 488

Alexa Fluor® 488 Anti-Sialoadhesin/CD169 antibody [EPR27102-11]
603 Alexa Fluor® 568

Alexa Fluor® 568 Anti-Sialoadhesin/CD169 antibody [EPR27102-11]
665 Alexa Fluor® 647

Alexa Fluor® 647 Anti-Sialoadhesin/CD169 antibody [EPR27102-11]

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR27102-11

亚型

IgG

偶联物

激发波长/发射波长

Ex: 480;565nm, Em: 578nm

不含载体蛋白

反应种属

Mouse, Mouse, Rat

应用

Flow Cyt, ICC/IF, IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/5000", "FlowCyt-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle|Store in the dark

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response (PubMed : 24788876). Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs) (PubMed : 26370074). In turn, enhances macrophage-to-T-cell transmission of several viruses including murine leukemia virus (PubMed : 26370074). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (By similarity).

See full target information Siglec1

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

PE Anti-Sialoadhesin/CD169 antibody [EPR27102-11]