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AB93589

PE Anti-PD-L2抗体[TY25]

PE Anti-PD-L2 antibody [TY25]

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(4 Publications)

Rat Monoclonal PD-L2 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Cell preparation containing Pdcd1lg2 protein.

查看别名

CD273, B7dc, Btdc, Cd273, Pdl2, Pdcd1lg2, Programmed cell death 1 ligand 2, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, B7-DC

1 Images
Flow Cytometry - PE Anti-PD-L2 antibody [TY25] (AB93589)
  • Flow Cyt

Unknown

Flow Cytometry - PE Anti-PD-L2 antibody [TY25] (AB93589)

Staining of non-transfected (left) and mouse PD-L2 transfected (right) cells with 0.25μg PE Rat IgG2a isotype control (open histogram) or 0.06μg ab93589 (colored histogram). Total viable cells were used for analysis.

关键信息

宿主种属

Rat

克隆

Monoclonal

克隆号

TY25

亚型

IgG2a

轻链类型

kappa

偶联物

PE

激发波长/发射波长

Ex: 480;565nm, Em: 578nm

不含载体蛋白

No

反应种属

Mouse

应用

Flow Cyt

applications

免疫原

Cell preparation containing Pdcd1lg2 protein. The exact immunogen used to generate this antibody is proprietary information.

Q9WUL5

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.06-0.5 µg for 10^5-10^8 Cells", "FlowCyt-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
存储溶液
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS, 0.87% Sodium chloride
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PD-L2 also known as PDCD1LG2 or B7-DC is a member of the B7 protein family that plays a role in immune system regulation. This protein has a molecular mass of approximately 25 kDa. PD-L2 is expressed in antigen-presenting cells such as dendritic cells and macrophages. Expression is also located in some subsets of T cells and B cells. The PD-L2 can act as a second ligand for the PD-1 receptor which is important in immune checkpoints.
Biological function summary

PD-L2 offers protection to tissues from autoimmunity by regulating T-cell activation and fostering tolerance. By engaging with its receptor PD-1 PD-L2 forms a complex that modulates the immune response to prevent overactivation. This interaction limits the immune system's potential damage to healthy tissues maintaining proper immune function in diverse environments.

Pathways

PD-L2 participates in the immune checkpoint pathways where it works closely with PD-1 to mediate immune responses. PD-L2 forms an important part of the program death-1 (PD-1) pathway which plays a prominent role in downregulating T-cell activity. It relates to proteins such as PD-L1 which also interacts with PD-1 modulating immune tolerance and response to infections or tumors.

PD-L2 involvement has been significant in cancer immunology and autoimmune conditions. Its interaction with PD-1 relates to the suppression of immune responses in tumors contributing to cancer progression. PD-L2's function as an immune checkpoint ligand associates with autoimmune diseases like rheumatoid arthritis where immune regulation goes awry. Both PD-1 and PD-L2 represent potential targets for therapeutic interventions due to their roles in these conditions.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Plays a critical role in induction and maintenance of immune tolerance to self (PubMed : 11224527, PubMed : 11283156, PubMed : 12719480, PubMed : 18641123). Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progression and cytokine production (PubMed : 11224527, PubMed : 11283156, PubMed : 12719480, PubMed : 18641123).
See full target information Pdcd1lg2
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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of immunology (Baltimore, Md. : 1950) 179:5204-10 PubMed17911605

2007

PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection.

Applications

Unspecified application

Species

Unspecified reactive species

Katsunori Tanaka,Monica J Albin,Xueli Yuan,Kazuhiro Yamaura,Antje Habicht,Takaya Murayama,Martin Grimm,Ana Maria Waaga,Takuya Ueno,Robert F Padera,Hideo Yagita,Miyuki Azuma,Tahiro Shin,Bruce R Blazar,David M Rothstein,Mohamed H Sayegh,Nader Najafian

Journal of immunology (Baltimore, Md. : 1950) 171:4156-63 PubMed14530338

2003

Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Takanori Kanai,Teruji Totsuka,Koji Uraushihara,Shin Makita,Tetsuya Nakamura,Kazutaka Koganei,Tsuneo Fukushima,Hisaya Akiba,Hideo Yagita,Ko Okumura,Utako Machida,Hideyuki Iwai,Miyuki Azuma,Lieping Chen,Mamoru Watanabe

The Journal of experimental medicine 198:63-9 PubMed12847137

2003

The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.

Applications

Unspecified application

Species

Unspecified reactive species

Mohammed Javeed I Ansari,Alan D Salama,Tanuja Chitnis,R Neal Smith,Hideo Yagita,Hisaya Akiba,Tomohide Yamazaki,Miyuki Azuma,Hideyuki Iwai,Samia J Khoury,Hugh Auchincloss,Mohamed H Sayegh

Journal of immunology (Baltimore, Md. : 1950) 169:5538-45 PubMed12421930

2002

Expression of programmed death 1 ligands by murine T cells and APC.

Applications

Unspecified application

Species

Unspecified reactive species

Tomohide Yamazaki,Hisaya Akiba,Hideyuki Iwai,Hironori Matsuda,Mami Aoki,Yuka Tanno,Tahiro Shin,Haruo Tsuchiya,Drew M Pardoll,Ko Okumura,Miyuki Azuma,Hideo Yagita
View all publications
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替代产品

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搭配使用产品

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Secondary Antibodies

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