重组PE Anti-Myosin light chain kinase/MLCK抗体[EP1458Y] (ab317912)
![PE Anti-Myosin light chain kinase/MLCK antibody [EP1458Y] (ab317912)](https://www.abcam.cn/ps/products/317/ab317912/Images/ab317912-1-MTOConjugatedRecombinantAntibodyBenefits.jpg "PE Anti-Myosin light chain kinase/MLCK antibody [EP1458Y] (ab317912)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- PE Rabbit monoclonal [EP1458Y] to Myosin light chain kinase/MLCK
- Suitable for: Antibody labelling, Target binding affinity
- Conjugation: PE. Ex: 488nm, Em: 575nm
Related conjugates and formulations
概述
-
产品名称
PE Anti-Myosin light chain kinase/MLCK抗体[EP1458Y]
参阅全部 Myosin light chain kinase/MLCK 一抗 -
描述
PE兔单克隆抗体[EP1458Y] to Myosin light chain kinase/MLCK -
宿主
Rabbit -
偶联物
PE. Ex: 488nm, Em: 575nm -
经测试应用
适用于: Antibody labelling, Target binding affinitymore details -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
-
常规说明
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for Abtrial: learn more here.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at +4°C. Avoid freeze / thaw cycle. Store In the Dark. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EP1458Y -
同种型
IgG -
研究领域
相关产品
-
Alternative Versions
-
Isotype control
-
Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab317912于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Antibody labelling |
Use at an assay dependent concentration.
|
|
| Target binding affinity |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
Antibody labelling
Use at an assay dependent concentration. |
|
Target binding affinity
Use at an assay dependent concentration. |
靶标
-
功能
Calcium/calmodulin-dependent enzyme implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activty (By similarity). Implicated in the regulation of endothelial as well as vascular permeability. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. -
组织特异性
Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin has been found in a wide variety of adult and fetal tissues. -
序列相似性
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Contains 1 fibronectin type-III domain.
Contains 9 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
翻译后修饰
MLCK is probably down-regulated by phosphorylation.
The C-terminus is deglutamylated by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6, leading to the formation of Myosin light chain kinase, smooth muscle, deglutamylated form. The consequences of C-terminal deglutamylation are unknown. - Information by UniProt
-
别名
- deglutamylated form antibody
- DKFZp686I10125 antibody
- EC 2.7.11.18 antibody
see all
图片
-
PE Anti-Myosin light chain kinase/MLCK antibody [EP1458Y] (ab317912)
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
-
SDS download
-
Datasheet download
文献 (0)
ab317912 尚未被引用在任何文献中。