PE Anti-KLRG1抗体[2F1] (ab25205)
Key features and details
- PE Syrian hamster monoclonal [2F1] to KLRG1
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG
Related conjugates and formulations
概述
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产品名称
PE Anti-KLRG1抗体[2F1]
参阅全部 KLRG1 一抗 -
描述
PE叙利亚仓鼠单克隆抗体[2F1] to KLRG1 -
宿主
Syrian hamster -
偶联物
PE. Ex: 488nm, Em: 575nm -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Tissue, cells or virus corresponding to Mouse KLRG1.
Database link: 50928 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. Do Not Freeze. Store undiluted. -
存储溶液
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.14% Monobasic dihydrogen sodium phosphate, 0.87% Sodium chloride, 0.1% Gelatin -
Concentration information loading... -
纯度
Affinity purified -
克隆
单克隆 -
克隆编号
2F1 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab25205于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
Flow Cyt
Use at an assay dependent concentration. |
靶标
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功能
Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. -
组织特异性
Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells. -
序列相似性
Contains 1 C-type lectin domain. -
结构域
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 50928 Mouse
- SwissProt: O88713 Mouse
- Unigene: 20434 Mouse
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别名
- 2F1 Ag antibody
- 2F1 antibody
- C type lectin domain family 15 member A antibody
see all
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (8)
ab25205 被引用在 8 文献中.
- Pauken KE et al. The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection. Cell Rep 31:107827 (2020). PubMed: 32610128
- Jennings RN et al. Type I interferon signaling enhances CD8+ T cell effector function and differentiation during murine gammaherpesvirus 68 infection. J Virol 88:14040-9 (2014). PubMed: 25253356
- Allie SR et al. Critical role for all-trans retinoic acid for optimal effector and effector memory CD8 T cell differentiation. J Immunol 190:2178-87 (2013). PubMed: 23338237
- Amoah S et al. High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion. J Immunol 190:5020-9 (2013). PubMed: 23589620
- Dong H et al. CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8(+) T cell memory in the absence of CD4(+) T cell help. J Immunol 188:3829-38 (2012). Flow Cyt . PubMed: 22422886
- Amoah S et al. Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection. J Immunol 189:638-45 (2012). PubMed: 22706075
- Allie SR et al. Programmed death 1 regulates development of central memory CD8 T cells after acute viral infection. J Immunol 186:6280-6 (2011). Flow Cyt ; Mouse . PubMed: 21525385
- Blackburn SD et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 10:29-37 (2009). Flow Cyt ; Mouse . PubMed: 19043418