AB131602

PE Anti-Kappa light chain抗体[TB28-2]，prediluted

Name: PE Anti-Kappa light chain抗体[TB28-2] (ab131602)| Abcam中文官网
Brand: Abcam Limited
SKU: AB131602
Price: 4659 CNY
Availability: InStock

PE Anti-Kappa light chain antibody [TB28-2]

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(2 Publications)

Mouse Monoclonal IGKC antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human IGKC.

查看别名

Immunoglobulin kappa constant, Ig kappa chain C region, Ig kappa chain C region AG, Ig kappa chain C region CUM, Ig kappa chain C region EU, Ig kappa chain C region OU, Ig kappa chain C region ROY, Ig kappa chain C region TI, IGKC

1 Images

Flow Cytometry - PE Anti-Kappa light chain antibody [TB28-2] (AB131602)

Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-Kappa light chain antibody [TB28-2] (AB131602)

Analysis by flow cytometry of ab131602 staining Kappa light chains in human peripheral blood cells.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

TB28-2

亚型

IgG1

偶联物

激发波长/发射波长

Ex: 480;565nm, Em: 578nm

不含载体蛋白

反应种属

Human

应用

Flow Cyt

applications

免疫原

Native Full Length Protein corresponding to Human IGKC.

P01834

特异性

ab131602 recognizes Human Ig kappa light chains of both secreted and cell surface immunoglobulin. It also detects free kappa light chains.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Size-exclusion chromatography

存储溶液

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS, 0.2% BSA

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The kappa light chain alternatively known as Ig kappa chain is a component of immunoglobulins which are important for immune response. This protein has a molecular mass of roughly 25 kDa. It predominantly expresses in B lymphocytes where it pairs with heavy chains to form antibodies. Its expression is indicative of mature B cell functions serving as a marker for certain types of immune cells. The kappa light chain can also be detected outside of cells circulating in the blood and other bodily fluids.

Biological function summary

Kappa light chains are integral to the structure and function of antibodies. As part of the immunoglobulin molecule these chains contribute to antigen specificity by combining with heavy chains. Together they form the antigen-binding site. The kappa light chain is not part of a multiprotein complex; rather it directly participates in the antibody response. The presence of either kappa or lambda light chains can determine the particularities of antibody characteristics.

Pathways

Kappa light chains are elements of the immunological pathways notably the adaptive immune response. They interact with other proteins like immunoglobulin heavy chains to neutralize pathogens. The constant region of the kappa chain plays a role in determining the isotype of immunoglobulins which affects how antibodies mediate immune effector functions. Cross-linking of surface immunoglobulin by antigens can trigger B cell activation an essential step in the adaptive immune system.

Kappa light chains associate closely with multiple myeloma and certain types of lymphomas. Overproduction of kappa light chains in these diseases results in high levels detectable in the serum or urine which can be used diagnostically as markers. Also dysregulation of kappa chains correlates with autoimmune disorders whereby the immune system incorrectly targets its tissues. In disorders like these the interplay between kappa and lambda chains often arises showing imbalance between the two as a sign of abnormal B cell activity.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed : 20176268, PubMed : 22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed : 17576170, PubMed : 20176268).

See full target information IGKC

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cell & bioscience 12:26 PubMed35255981

2022

Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver.

Applications

Unspecified application

Species

Unspecified reactive species

Jilong Ren,Dawei Yu,Jing Wang,Kai Xu,Yanan Xu,Renren Sun,Peipei An,Chongyang Li,Guihai Feng,Ying Zhang,Xiangpeng Dai,Hongye Zhao,Zhengzhu Wang,Zhiqiang Han,Haibo Zhu,Yuchun Ding,Xiaoyan You,Xueqin Liu,Meng Wu,Lin Luo,Ziyi Li,Yong-Guang Yang,Zheng Hu,Hong-Jiang Wei,Liangpeng Ge,Tang Hai,Wei Li

PloS one 11:e0165385 PubMed27788210

2016

Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Alina Fedoseienko,Hylke W Wieringa,G Bea A Wisman,Evelien Duiker,Anna K L Reyners,Marten H Hofker,Ate G J van der Zee,Bart van de Sluis,Marcel A T M van Vugt

View all publications

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PE Anti-Kappa light chain抗体[TB28-2]，prediluted

PE Anti-Kappa light chain antibody [TB28-2]

Flow Cytometry - PE Anti-Kappa light chain antibody [TB28-2] (AB131602)

关键信息

宿主种属

克隆

克隆号

亚型

偶联物

激发波长/发射波长

不含载体蛋白

反应种属

应用

免疫原

特异性