PE Anti-Integrin alpha 2抗体[DX5] (ab25493)
![Flow Cytometry - PE Anti-Integrin alpha 2 antibody [DX5] (ab25493)](https://www.abcam.cn/ps/products/25/ab25493/Images/ab25493-271910-anti-integrin-alpha-2-antibody-dx5-phycoerythrin-flow-cytometry.jpg "Flow Cytometry - PE Anti-Integrin alpha 2 antibody [DX5] (ab25493)")
Key features and details
- PE Rat monoclonal [DX5] to Integrin alpha 2
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgM
概述
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产品名称
PE Anti-Integrin alpha 2抗体[DX5]
参阅全部 Integrin alpha 2 一抗 -
描述
PE大鼠单克隆抗体[DX5] to Integrin alpha 2 -
宿主
Rat -
偶联物
PE. Ex: 488nm, Em: 575nm -
经测试应用
适用于: Flow Cytmore details
不适用于: IHC-Fr or IHC-P -
种属反应性
与反应: Mouse -
免疫原
Tissue, cells or virus corresponding to Mouse Integrin alpha 2. NK cells isolated from C57BL/6 mice
Database link: Q62469 -
常规说明
NK cells cultured in the presence of IL2 progressively lose reactivity with DX5 as a consequence of cellular proliferation. Therefore, DX5 can be used to define functionally distinct subsets of murine NK cells. DX5 has not been demonstrated to have activating or blocking activity.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. Store In the Dark. -
存储溶液
pH: 7.3
Preservative: 0.09% Sodium azide
Constituents: PBS, 16% Sucrose
Also contains a stabilizing agent. -
Concentration information loading... -
纯度
Purified IgM -
Primary antibody说明
NK cells cultured in the presence of IL2 progressively lose reactivity with DX5 as a consequence of cellular proliferation. Therefore, DX5 can be used to define functionally distinct subsets of murine NK cells. DX5 has not been demonstrated to have activating or blocking activity. -
克隆
单克隆 -
克隆编号
DX5 -
骨髓瘤
Sp2/0 -
同种型
IgM -
轻链类型
kappa -
研究领域
相关产品
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Alternative Versions
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab25493于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
Use 0.2µg for 106 cells.
ab25493 can be used to define functionally distinct subsets of murine NK cells. |
| 说明 |
|---|
|
Flow Cyt
Use 0.2µg for 106 cells. ab25493 can be used to define functionally distinct subsets of murine NK cells. |
靶标
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功能
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. -
序列相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
结构域
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 16398 Mouse
- SwissProt: Q62469 Mouse
- Unigene: 5007 Mouse
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别名
- BR antibody
- CD 49b antibody
- CD49 antigen like family member B antibody
see all
图片
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Flow Cytometry - PE Anti-Integrin alpha 2 antibody [DX5] (ab25493)
Flow Cytometry analysis of C57BL/6 mouse splenocytes stained with Anti-Integrin alpha 2 antibody [DX5] (Phycoerythrin) (ab25493) and mouse anti-mouse NK1.1-FITC.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab25493 被引用在 1 文献中.
- Arase H et al. Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2). J Immunol 167:1141-4 (2001). PubMed: 11466327