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AB55863

PE Anti-DR5抗体[DR5-01-1]

PE Anti-DR5 antibody [DR5-01-1]

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(2 Publications)

Anti-DR5 antibody [DR5-01-1] conjugated to PE - suitable for flow cytometry, intracellular flow cytometry, and reacts with human samples. Clone [DR5-01-1] is a mouse monoclonal antibody cited in 5 publications.

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查看别名

CD262, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, UNQ160/PRO186, TNFRSF10B, Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2

1 Images
Flow Cytometry - PE Anti-DR5 antibody [DR5-01-1] (AB55863)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-DR5 antibody [DR5-01-1] (AB55863)

Flow cytometry analysis (surface staining) of CD262 on CD262-transfectants with the antibody to CD262 (DR5-01-1) PE.

不同偶联物与剂型 (1)

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

DR5-01-1

亚型

IgG1

偶联物

PE

激发波长/发射波长

Ex: 480;565nm, Em: 578nm

不含载体蛋白

No

反应种属

Human

应用

Flow Cyt

applications

免疫原

Fusion protein corresponding to TNFRSF10B, fused to IGG1_HUMAN and to TNFRSF10B. The exact immunogen used to generate this antibody is proprietary information.

O14763

特异性

This recognizes an extracellular domain of TRAIL R2 (DR5).

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替代产品

Primary Antibodies

AB8416

Anti-DR5 antibody

Immunocytochemistry - Anti-DR5 antibody (AB8416)

  • 4
  • 5
Primary Antibodies

AB16329

Anti-DR5 antibody

Immunocytochemistry - Anti-DR5 antibody (AB16329)

  • 3
  • 1
Primary Antibodies

AB95619

PE Anti-DR5 antibody [MD5-1]

Flow Cytometry - PE Anti-DR5 antibody [MD5-1] (AB95619)

  • 0
  • 0
Primary Antibodies

AB53319

FITC Anti-DR5 antibody [DR5-01-1]

Flow Cytometry - FITC Anti-DR5 antibody [DR5-01-1] (AB53319)

  • 0
  • 0
Primary Antibodies

AB199357

Anti-DR5 antibody [EPR19310]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-DR5 antibody [EPR19310] (AB199357)

  • 5
  • 5
Primary Antibodies

AB230969

Anti-DR5 antibody [EPR22276]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DR5 antibody [EPR22276] (AB230969)

  • 0
  • 0
Primary Antibodies

AB243847

Anti-DR5 antibody [EPR22276] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DR5 antibody [EPR22276] - BSA and Azide free (AB243847)

  • 0
  • 0

搭配使用产品

Assay Kits

AB46013

Human DR5 ELISA Kit (CD262)

Sandwich ELISA - Human DR5 ELISA Kit (CD262) (AB46013)

  • 0
  • 0
Primary Antibodies

AB183474

PE Anti-TRAIL antibody [2E5]

  • 0
  • 0
Primary Antibodies

AB317769

Alexa Fluor® 647 Anti-DR4 antibody [EPR28152-57]

Recombinant|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-DR4 antibody [EPR28152-57] (AB317769)

  • 0
  • 0
Primary Antibodies

AB200315

Alexa Fluor® 488 Anti-CD45 antibody [EP322Y]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Alexa Fluor® 488 Anti-CD45 antibody [EP322Y] (AB200315)

  • 0
  • 0
Primary Antibodies

AB184787

Anti-Caspase-3 antibody [EPR18297]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-3 antibody [EPR18297] (AB184787)

  • 3
  • 3
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-5 µg/mL", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/pe-mouse-igg1-b11-6-isotype-control-ab91357'>ab91357</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Size-exclusion chromatography
存储溶液
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: 0.2% BSA
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

DR5 also known as Death Receptor 5 TRAIL-R2 or TNFRSF10B is a protein critical in apoptosis. It is a transmembrane receptor with a mass of approximately 54 kDa. Researchers find it expressed mostly in tissues such as lung colon and prostate. DR5 functions by binding to its ligand TRAIL triggering the extrinsic apoptotic pathway. Through this mechanism DR5 initiates a cascade of caspase activation that leads to cell death.
Biological function summary

DR5 plays a significant role in the regulation of apoptosis particularly in cancer cells. It is a component of the TRAIL receptor complex which includes several other death receptors like DR4. This complex formation allows DR5 to mediate apoptotic signals more efficiently. By controlling apoptosis DR5 helps maintain tissue homeostasis and prevents abnormal cell proliferation.

Pathways

DR5 is an important part of the TRAIL signaling pathway and the extrinsic apoptosis pathway. It connects with proteins like FADD and Caspase-8 essential in the apoptotic signaling cascade. By interacting with these proteins DR5 drives the progression of the apoptotic signal ensuring the removal of dysfunctional cells. Such pathways are vital for restraining tumor development and progression.

DR5 exhibits significant relevance to cancer and autoimmune diseases. Its ability to induce apoptosis through the TRAIL pathway keeps oncogenic transformations in check. In cancer DR5 often interfaces with other proteins like Bcl-2 which are involved in cell survival. Furthermore defects or aberrant expressions in DR5 have associations with autoimmune disorders where excessive cell death or survival contributes to disease pathology. DR5's role in these conditions makes it a promising target in therapeutic strategies.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed : 10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
See full target information TNFRSF10B
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 9: PubMed31817770

2019

Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Seon Min Woo,Seung Un Seo,Peter Kubatka,Kyoung-Jin Min,Taeg Kyu Kwon

Bioinorganic chemistry and applications 2018:7578965 PubMed30154833

2018

Luminescent Iridium Complex-Peptide Hybrids (IPHs) for Therapeutics of Cancer: Design and Synthesis of IPHs for Detection of Cancer Cells and Induction of Their Necrosis-Type Cell Death.

Applications

Unspecified application

Species

Unspecified reactive species

Abdullah-Al Masum,Yosuke Hisamatsu,Kenta Yokoi,Shin Aoki
View all publications
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