AB25272

PE/Cy5® Anti-CD90 / Thy1抗体[G7]

Name: PE/Cy5® Anti-CD90 / Thy1抗体[G7] (ab25272)| Abcam中文官网
Brand: Abcam Limited
SKU: AB25272
Price: 2940 CNY
Availability: InStock
Rating: 5 (1 reviews)

PE/Cy5® Anti-CD90 / Thy1 antibody [G7]

(1 Review)

(9 Publications)

Anti-CD90 / Thy1 antibody [G7] conjugated to PE/Cy5® - suitable for flow cytometry, and reacts with mouse samples. Clone [G7] is a rat monoclonal antibody cited in 75 publications.

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查看别名

CD90, Thy-1 membrane glycoprotein, CDw90, Thy-1 antigen, THY1

1 Images

Flow Cytometry - PE/Cy5® Anti-CD90 / Thy1 antibody [G7] (AB25272)

Flow Cyt

Unknown

Flow Cytometry - PE/Cy5® Anti-CD90 / Thy1 antibody [G7] (AB25272)

Flow Cytometry analysis of C57BL/6 mouse splenocytes stained with Anti-CD90 / Thy1 antibody [G7] (PE/Cy5) ab25272 (1 μg/10⁶cells) and Rat Anti-Mouse CD3-epsilon-PE.

不同偶联物与剂型 (4)

660 APC

APC Anti-CD90 / Thy1 antibody [G7]
Biotin

Biotin Anti-CD90 / Thy1 antibody [G7]
519 FITC

FITC Anti-CD90 / Thy1 antibody [G7]
578 PE

PE Anti-CD90 / Thy1 antibody [G7]

关键信息

宿主种属

Rat

克隆

Monoclonal

克隆号

亚型

IgG2c

轻链类型

kappa

偶联物

PE/Cy5®

激发波长/发射波长

Ex: 496nm, Em: 667nm

不含载体蛋白

反应种属

Mouse

应用

Flow Cyt

applications

特异性

ab25272 is specific for Thy-1.1 and Thy-1.2 alloantigens (Thy-1 epitope region A).

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.2 µg for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }

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产品详情

ab25272 stimulates T-cell proliferation and IL-2 secretion, via signalling through the T-cell receptor/CD3 complex. ab25272 has also been reported to promote apoptosis of thymocytes and CTL clones, and to mediate adhesion of thymocytes to thymic stroma.

This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5, 268, 486 and related patents. Cy® and CyDye® are trademarks of Cytiva.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification

存储溶液

pH: 7.1 Preservative: 0.09% Sodium azide Constituents: PBS, 16% Sucrose, 0.2% Gelatin

运输条件

Blue Ice

储存信息

Store in the dark

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD90 also known as Thy1 is a glycoprotein with a molecular mass of approximately 25-37 kDa. It is highly conserved across species and found on the surface of various cell types including fibroblasts neurons and endothelial cells. CD90 is expressed in these cells in tissues such as the brain thymus and lungs. Researchers use anti-CD90 antibodies for detection often in combination with CD90 FITC in immunofluorescence assays. CD90 serves as a useful cell marker particularly in identifying mesenchymal stem cells (MSCs).

Biological function summary

CD90 plays a role in cell-cell and cell-matrix interactions contributing to cellular adhesion migration and signal transduction. It functions as part of a complex involving integrins which mediate its interaction with the extracellular matrix. This protein also influences T-cell activation reflecting its importance in immune response regulation. Its presence aids in modulating response to injury and promoting tissue repair due to its association with stem and progenitor cells.

Pathways

CD90 engagement affects focal adhesion and MAPK signaling pathways. It interacts with integrins like αvβ3 and α5β1 influencing cell movement and proliferation processes. CD90 involvement in these pathways allows it to regulate responses important for cell survival and communication within various tissues. These interactions highlight the protein's role in maintaining cellular homeostasis and regulating physiological processes.

CD90 has associations with fibrosis and cancer. In fibrotic conditions CD90 expression affects fibroblast activity influencing tissue scarring in organs such as the liver and lungs. In cancer CD90 modifies tumor progression and metastasis by impacting cell adhesion and migration with connections to proteins like TGF-beta which further drive these processes. Understanding CD90 in disease contexts facilitates the development of therapeutic strategies aimed at modulating its activity.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

See full target information THY1

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文献 (9)

Recent publications for all applications. Explore the full list and refine your search

Experimental physiology 105:876-885 PubMed32052500

2020

microRNA-143-3p regulates odontogenic differentiation of human dental pulp stem cells through regulation of the osteoprotegerin-RANK ligand pathway by targeting RANK.

Applications

Unspecified application

Species

Unspecified reactive species

Changwei Yang,Ru Jia,Qiliang Zuo,Yanfen Zheng,Qianju Wu,Bizhu Luo,Pingting Lin,Lu Yin

IUBMB life 72:665-676 PubMed31889420

2020

Synergistic effects of Rho kinase inhibitor Y-27632 and Noggin overexpression on the proliferation and neuron-like cell differentiation of stem cells derived from human exfoliated deciduous teeth.

Applications

Unspecified application

Species

Unspecified reactive species

Si Yang,Cuijuan Xin,Bo Zhang,Hongbo Zhang,Yunpeng Hao

Molecular medicine reports 19:813-820 PubMed30569163

2018

Effects of menstrual blood‑derived stem cells on endometrial injury repair.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Hu,Kuangyu Song,Jing Zhang,Yiqiong Zhang,Bu-Zhen Tan

The Journal of experimental medicine 179:785-96 PubMed7906706

1994

Thy-1 triggers mouse thymocyte apoptosis through a bcl-2-resistant mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

A O Hueber,G Raposo,M Pierres,H T He

Journal of immunology (Baltimore, Md. : 1950) 149:1583-92 PubMed1380534

1992

Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death.

Applications

Unspecified application

Species

Unspecified reactive species

D S Ucker,J Meyers,P S Obermiller

The Journal of experimental medicine 173:515-8 PubMed1671083

1991

Thy-1 supports adhesion of mouse thymocytes to thymic epithelial cells through a Ca2(+)-independent mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

H T He,P Naquet,D Caillol,M Pierres

Cellular immunology 130:271-80 PubMed1976441

1990

Selection of T cell receptor expression mutants through the functionally linked Ly-6A.

Applications

Unspecified application

Species

Unspecified reactive species

E Sugiyama,A Cantagrel,T Reno,F Stafford-Brady,E T Yeh,J V Bonventre

Journal of immunology (Baltimore, Md. : 1950) 140:1089-94 PubMed2893823

1988

Proliferation and production of IL-2 and B cell stimulatory factor 1/IL-4 in early fetal thymocytes by activation through Thy-1 and CD3.

Applications

Unspecified application

Species

Unspecified reactive species

L Tentori,D M Pardoll,J C Zuñiga,J Hu-Li,W E Paul,J A Bluestone,A M Kruisbeek

The Journal of experimental medicine 159:716-30 PubMed6142077

1984

T cell-activating properties of an anti-Thy-1 monoclonal antibody. Possible analogy to OKT3/Leu-4.

Applications

Unspecified application

Species

Unspecified reactive species

K C Gunter,T R Malek,E M Shevach

View all publications

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PE/Cy5® Anti-CD90 / Thy1抗体[G7]