PE Anti-CD24抗体[SN3] (ab77219)
Key features and details
- PE Mouse monoclonal [SN3] to CD24
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG1
Related conjugates and formulations
概述
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产品名称
PE Anti-CD24抗体[SN3]
参阅全部 CD24 一抗 -
描述
PE小鼠单克隆抗体[SN3] to CD24 -
宿主
Mouse -
偶联物
PE. Ex: 488nm, Em: 575nm -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus corresponding to Human CD24. Glycoproteins purified from human NALM-1 cell line
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阳性对照
- Human blood cells.
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常规说明
Purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.4
Preservative: 0.097% Sodium azide
Constituent: 0.2% BSA
0.2% (w/v) high-grade protease free BSA -
Concentration information loading... -
纯度
Size exclusion -
克隆
单克隆 -
克隆编号
SN3 -
同种型
IgG1 -
研究领域
相关产品
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Alternative Versions
- Anti-CD24 antibody [SN3] (ab134375)
- APC/Cy7® Anti-CD24 antibody [SN3], prediluted (ab197137)
- APC Anti-CD24 antibody [SN3] (ab239286)
- PerCP/Cy5.5® Anti-CD24 antibody [SN3] (ab239339)
- Alexa Fluor® 700 Anti-CD24 antibody [SN3] (ab269310)
- FITC Anti-CD24 antibody [SN3] (ab30350)
- PE Anti-CD24 antibody [SN3], prediluted (ab30351)
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab77219于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt | (1) |
Use 20µl for 106 cells.
ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 20µl per 100µl of whole blood or 106 cells in suspension. |
| 说明 |
|---|
|
Flow Cyt
Use 20µl for 106 cells. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 20µl per 100µl of whole blood or 106 cells in suspension. |
靶标
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功能
Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. -
组织特异性
B-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. -
疾病相关
Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface. -
序列相似性
Belongs to the CD24 family. -
翻译后修饰
Extensively O-glycosylated. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 100133941 Human
- Omim: 600074 Human
- SwissProt: P25063 Human
- Unigene: 644105 Human
- Unigene: 721443 Human
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别名
- CD 24 antibody
- CD24 antibody
- CD24 antigen (small cell lung carcinoma cluster 4 antigen) antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (11)
ab77219 被引用在 11 文献中.
- Yang XL et al. microRNA-873 inhibits self-renewal and proliferation of pancreatic cancer stem cells through pleckstrin-2-dependent PI3K/AKT pathway. Cell Signal 84:110025 (2021). PubMed: 33915247
- Weinberg F et al. EGFR Expression in HER2-Driven Breast Cancer Cells. Int J Mol Sci 21:N/A (2020). PubMed: 33260837
- Quayle LA et al. Chemotherapy resistance and stemness in mitotically quiescent human breast cancer cells identified by fluorescent dye retention. Clin Exp Metastasis 35:831-846 (2018). PubMed: 30377878
- Peckys DB et al. Liquid-phase electron microscopy of molecular drug response in breast cancer cells reveals irresponsive cell subpopulations related to lack of HER2 homodimers. Mol Biol Cell N/A:N/A (2017). PubMed: 28794264
- Sagara A et al. Intrinsic Resistance to 5-Fluorouracil in a Brain Metastatic Variant of Human Breast Cancer Cell Line, MDA-MB-231BR. PLoS One 11:e0164250 (2016). PubMed: 27723829