AB183463

PE Anti-CD200 / OX2抗体[OX-104]，prediluted

Name: PE Anti-CD200 / OX2抗体[OX-104] (ab183463)| Abcam中文官网
Brand: Abcam Limited
SKU: AB183463
Price: 1089 CNY
Availability: InStock

PE Anti-CD200 / OX2 antibody [OX-104]

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(1 Publication)

Mouse Monoclonal CD200 / OX2 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CD200.

查看别名

CD200, MOX1, MOX2, My033, OX-2 membrane glycoprotein

3 Images

Flow Cytometry - PE Anti-CD200 / OX2 antibody [OX-104] (AB183463)

Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-CD200 / OX2 antibody [OX-104] (AB183463)

Flow cytometry analysis of human peripheral blood labeling CD200/OX2 using ab183463 at 10 µL/100ul peripheral whole blood. Surface staining.

Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-CD200 / OX2 antibody [OX-104] (AB183463)

Flow cytometry analysis of human peripheral blood labeling CD200/OX2 using ab183463 at 10 µL/100ul peripheral whole blood. CD3 is labeled with an Anti-Human CD3-APC conjugate at 10 µL/100 µL peripheral whole blood. Surface staining.

Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-CD200 / OX2 antibody [OX-104] (AB183463)

Flow cytometry analysis of human peripheral blood labeling CD200/OX2 using ab183463 at 10 µL/100ul peripheral whole blood. CD19 is labeled with an Anti-human CD19-APC conjugate at 10 µL/100ul peripheral whole blood. Surface staining.

不同偶联物与剂型 (2)

387 mFluor™ UV375

mFluor™ UV375 Anti-CD200 antibody [OX-104]
454 mFluor™ Violet 450

mFluor™ Violet 450 Anti-CD200 antibody [OX-104]

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

OX-104

亚型

IgG1

偶联物

激发波长/发射波长

Ex: 480;565nm, Em: 578nm

不含载体蛋白

反应种属

Human

应用

Flow Cyt

applications

免疫原

Recombinant Fragment Protein within Human CD200. The exact immunogen used to generate this antibody is proprietary information.

P41217

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>10 μl reagent / 100 μl of whole blood or 10<sup>6</sup> cells in a suspension.</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Size-exclusion chromatography

纯化说明

Purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

存储溶液

pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 0.2% BSA

运输条件

Blue Ice

储存信息

Store in the dark

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD200 also known as OX2 is a cell surface glycoprotein with a molecular mass of approximately 43 kDa. It plays a mechanical role in immune response regulation. CD200 expression occurs on several cell types such as thymocytes neurons vascular endothelium and splenocytes including cynomolgus monkey splenocytes. This protein generally modulates interactions between cells sending inhibitory signals through its receptor CD200R found on myeloid cells and certain lymphoid cells.

Biological function summary

CD200 regulates the immune system by inhibiting inflammatory responses and maintaining immune homeostasis. It does not act as part of a significant multi-protein complex but directly interacts with CD200R. This interaction promotes an anti-inflammatory state and is important in preventing autoimmune diseases and excessive tissue damage. The expression of CD200 is also an indicator of immune tolerance in various tissues.

Pathways

CD200 is involved in immune regulatory pathways. It plays a pivotal role in the suppression of immune responses through the CD200-CD200R signaling pathway. This pathway is vital for dampening inflammatory processes related to autoimmune reactions and is consequently linked to the maintenance of tissue homeostasis. Proteins related to CD200 through these pathways include CD200R and other molecules involved in immune checkpoint pathways.

CD200 expression correlates with several conditions including cancer and autoimmune diseases. The overexpression of CD200 in certain tumors promotes immune evasion thereby favoring tumor progression. Conversely reduced CD200 levels are associated with autoimmune disorders where a hyperactive immune system attacks self-tissues. Through these disease contexts CD200 operates alongside proteins such as CD200R and OX90 impacting disease progression and immune system modulation.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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靶点信息

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

See full target information CD200

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Alzheimer's & dementia : the journal of the Alzheimer's Association 20:6094-6106 PubMed38958575

2024

Nanoscale flow cytometry-based quantification of blood-based extracellular vesicle biomarkers distinguishes MCI and Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Thamara Dayarathna,Austyn D Roseborough,Janice Gomes,Reza Khazaee,Carolina R A Silveira,Kathy Borron,Soojung Yu,Kristy Coleman,Sarah Jesso,Elizabeth Finger,Penny MacDonald,Michael Borrie,Jennie Wells,Robert Bartha,Guangyong Zou,Shawn N Whitehead,Hon S Leong,Stephen H Pasternak

View all publications

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PE Anti-CD200 / OX2抗体[OX-104]，prediluted