AB232916

PE Anti-CD1b抗体[SN13]

Name: PE Anti-CD1b抗体[SN13] (ab232916)| Abcam中文官网
Brand: Abcam Limited
SKU: AB232916
Price: 1336 CNY
Availability: InStock

PE Anti-CD1b antibody [SN13]

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(1 Publication)

Anti-CD1b antibody [SN13] conjugated to PE - suitable for flow cytometry, and reacts with human samples. Clone [SN13] is a mouse monoclonal antibody.

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查看别名

CD1b, T-cell surface glycoprotein CD1b, CD1B

1 Images

Flow Cytometry - PE Anti-CD1b antibody [SN13] (AB232916)

Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-CD1b antibody [SN13] (AB232916)

Surface staining of IL-4 and GM-CSF stimulated human peripheral blood cells labeling CD1b with ab232916 (10 μl reagent / 100 μl of whole blood). Gating strategy : HLA^-DR⁺CD11c⁺ and CD11c^- cells.

Recommended negative control : ab125926.

不同偶联物与剂型 (4)

660 APC

APC Anti-CD1b antibody [SN13]
519 FITC

FITC Anti-CD1b antibody [SN13]
387 mFluor™ UV375

mFluor™ UV375 Anti-CD1b antibody [SN13]
454 mFluor™ Violet 450

mFluor™ Violet 450 Anti-CD1b antibody [SN13]

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

SN13

亚型

IgG1

偶联物

激发波长/发射波长

Ex: 480;565nm, Em: 578nm

不含载体蛋白

反应种属

Human

应用

Flow Cyt

applications

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Size-exclusion chromatography

存储溶液

pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS

运输条件

Blue Ice

储存信息

Store in the dark

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD1b also known as CD1B is a member of the CD1 family of glycoproteins with a molecular mass around 37 to 40 kilodaltons. It is expressed on the surface of antigen-presenting cells such as dendritic cells and some monocytes. CD1b plays a mechanical role in binding lipid-based antigens. This binding facilitates the presentation of these antigens to T cells. Its presence on the cell surface is essential for this antigen presentation function.

Biological function summary

CD1b functions in the immune system as part of the antigen presentation complex. It specifically presents lipid antigens derived from microbial sources to T cells helping create an immune response. The protein associates with beta-2 microglobulin which stabilizes its structure on the cell surface. CD1b can effectively capture and present mycobacterial lipid antigens which are important for the immune response against certain bacterial infections.

Pathways

CD1b actively contributes to immunity by participating in the lipid antigen presentation pathway. This pathway involves the trafficking of endogenous and exogenous lipids aided by proteins like saposins. CD1b interacts with other CD1 family proteins such as CD1a and CD1c which are involved in similar pathways for presenting different types of lipid antigens to T cells therefore diversifying the immune response.

CD1b is implicated in tuberculosis as Mycobacterium tuberculosis interacts with this protein to modulate the host's immune defenses. Defective CD1b function can influence the body's response to this pathogen potentially leading to a chronic infection state. It also relates to autoimmune diseases such as multiple sclerosis where dysregulated lipid antigen presentation might influence disease progression. In these conditions interactions with proteins like HLA-DR can modify the immune landscape and disease outcomes.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

See full target information CD1B

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Folia histochemica et cytobiologica 63:11-27 PubMed40152123

2025

Inhibition of STAT1 alleviates oxidative damage in retinal pigment epithelial cells and exhibits neuroprotective effects in autoimmune optic neuritis by upregulating IFI30 lysosomal thiol reductase.

Applications

Unspecified application

Species

Unspecified reactive species

Siqi Ma,Jiajia Yuan

View all publications

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PE Anti-CD1b抗体[SN13]