PE Anti-CD11b抗体[MEM-174] (ab28101)
![Flow Cytometry - PE Anti-CD11b antibody [MEM-174] (ab28101)](https://www.abcam.cn/ps/products/28/ab28101/Images/ab28101-284944-anti-cd11b-antibody-mem-174-phycoerythrin-flow-cytometry.jpg "Flow Cytometry - PE Anti-CD11b antibody [MEM-174] (ab28101)")
Key features and details
- PE Mouse monoclonal [MEM-174] to CD11b
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG2a
概述
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产品名称
PE Anti-CD11b抗体[MEM-174]
参阅全部 CD11b 一抗 -
描述
PE小鼠单克隆抗体[MEM-174] to CD11b -
宿主
Mouse -
偶联物
PE. Ex: 488nm, Em: 575nm -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus corresponding to Human CD11b. Human granulocytes
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常规说明
The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.40
Preservative: 0.097% Sodium azide
Constituents: PBS, 0.2% BSA -
Concentration information loading... -
纯度
IgG fraction -
纯化说明
Size exclusion chromatography. -
克隆
单克隆 -
克隆编号
MEM-174 -
同种型
IgG2a -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab28101于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt | (3) |
Use 20µl for 106 cells.
Use 20µl for 106 cells or 100µl of whole blood. ab91363 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
| 说明 |
|---|
|
Flow Cyt
Use 20µl for 106 cells. Use 20µl for 106 cells or 100µl of whole blood. ab91363 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. -
组织特异性
Predominantly expressed in monocytes and granulocytes. -
疾病相关
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. -
序列相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
结构域
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3684 Human
- Omim: 120980 Human
- SwissProt: P11215 Human
- Unigene: 172631 Human
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别名
- antigen CD11b (p170) antibody
- Antigen CD11b p170 antibody
- CD11 antigen like family member B antibody
see all
图片
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Flow Cytometry - PE Anti-CD11b antibody [MEM-174] (ab28101)
Flow cytometry analysis of human peripheral blood cells labelling CD11b with ab28101.
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![Flow Cytometry - PE Anti-CD11b antibody [MEM-174] (ab28101)](https://www.abcam.cn/ps/products/28/ab28101/Images/ab28101-207014-anti-cd11b-antibody-mem-174-phycoerythrin-flow-cytometry.jpg)
Flow Cytometry - PE Anti-CD11b antibody [MEM-174] (ab28101)This image is courtesy of an Abreview submitted by Ina Laura Pieperab28101 staining CD11b in Human peripheral blood cells by Flow Cytometry. The sample was incubated with the primary antibody (1/6) for 30 minutes at 4°C. Gating Strategy: Granulocytes.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab28101 被引用在 2 文献中.
- Li Z et al. Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A). Acta Pharm Sin B 9:794-808 (2019). PubMed: 31384539
- Wu H et al. Regenerative potential of human nucleus pulposus resident stem/progenitor cells declines with ageing and intervertebral disc degeneration. Int J Mol Med 42:2193-2202 (2018). PubMed: 30015833