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AB244756

重组Anti-PDGF CC抗体[EPR21022-28] - BSA and Azide free (Capture)

Anti-PDGF CC antibody [EPR21022-28] - BSA and Azide free (Capture)

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Rabbit Recombinant Monoclonal PDGFC antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

查看别名

SCDGF, UNQ174/PRO200, PDGFC, Platelet-derived growth factor C, PDGF-C, Fallotein, Spinal cord-derived growth factor, VEGF-E

1 Images
Sandwich ELISA - Anti-PDGF CC antibody [EPR21022-28] - BSA and Azide free (Capture) (AB244756)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-PDGF CC antibody [EPR21022-28] - BSA and Azide free (Capture) (AB244756)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab234568).

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR21022-28

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

sELISA

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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产品详情

ab244756 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human PDGF-CC. The recommended pair for sandwich ELISA is:
Capture: ab244756, Human PDGF-CC Capture Antibody (unconjugated)
Detector: ab245026, Human PDGF-CC Detector Antibody (unconjugated)
The reference range value is 28.125 - 1800 pg/ml.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Platelet-Derived Growth Factor CC (PDGF-CC) is a member of the PDGF family consisting of homodimeric and heterodimeric isoforms. PDGF-CC with a mass of approximately 44 kDa partakes in various cellular processes. It primarily expresses in fibroblasts endothelial cells and some types of neurons. PDGF-CC functions by binding to tyrosine kinase receptors specifically PDGFRαα and PDGFRαβ where it triggers intracellular signaling pathways.
Biological function summary

PDGF-CC influences cell proliferation migration and survival particularly in the context of vascular development and remodeling. It acts as a powerful growth factor for mesenchymal cells and plays a role in embryonic development. PDGF-CC forms a functional complex after proteolytic activation which is essential for its receptor-binding capacity. This factor significantly regulates angiogenesis and wound healing processes.

Pathways

PDGF-CC is integral to the PDGF signaling pathway and is involved in the PI3K/AKT signaling pathway. These pathways promote cellular growth survival and proliferation. PDGF-CC's interaction with PDGF receptors primarily PDGFRα facilitates these biological functions. In these pathways PDGF-CC interacts with other proteins such as PI3K and AKT connecting it to broader cellular response networks.

PDGF-CC has been associated with fibrotic diseases and certain cancers. Its overexpression or dysregulation can contribute to pathological fibrosis through excessive tissue repair. PDGF-CC is also linked to glioblastoma a type of brain cancer where abnormal PDGF signaling leads to tumor progression. PDGF-CC interacts with PDGFRα in these disease contexts highlighting its contribution to disease mechanisms when dysregulated.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages : inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
See full target information PDGFC
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搭配使用产品

Assay Kits

AB234568

Human PDGF-CC ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human PDGF-CC ELISA Kit (AB234568)

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Primary Antibodies

AB203911

Anti-PDGF AA antibody [EPR19924]

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Immunoprecipitation - Anti-PDGF AA antibody [EPR19924] (AB203911)

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  • 0
Primary Antibodies

AB178409

Anti-PDGF B antibody [EPR6834]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-PDGF B antibody [EPR6834] (AB178409)

  • 0
  • 0
Primary Antibodies

AB218192

Anti-Niemann Pick C2 antibody [EPR19993-145-1]

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-Niemann Pick C2 antibody [EPR19993-145-1] (AB218192)

  • 5
  • 1

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