AB171750

重组Anti-PDE4D抗体[EPR11823-31]

Name: PDE4D抗体[EPR11823-31] (ab171750)| Abcam中文官网
Brand: Abcam Limited
SKU: AB171750
Price: 2604 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-PDE4D antibody [EPR11823-31]

RabMAb
Recombinant
了解详情

(1 Review)

(17 Publications)

Rabbit Recombinant Monoclonal PDE4D antibody. Suitable for WB and reacts with Human samples. Cited in 17 publications.

查看别名

DPDE3, PDE4D, PDE43, cAMP-specific phosphodiesterase 4D

1 Images

Supplier Data

Western blot - Anti-PDE4D antibody [EPR11823-31] (AB171750)

All lanes:

Western blot - Anti-PDE4D antibody [EPR11823-31] (ab171750) at 1/1000 dilution

Lane 1:

Human fetal heart lysate at 10 µg

Lane 2:

Human fetal brain lysate at 10 µg

Predicted band size: 91 kDa

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关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR11823-31

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯度

Tissue culture supernatant

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Phosphodiesterase 4D (PDE4D) is an enzyme that hydrolyzes cyclic AMP (cAMP) to its inactive form AMP controlling important cellular signaling pathways. It is part of the large PDE family and sometimes referred to as DPDE1. With a molecular weight of approximately 93 kDa PDE4D is widely expressed in the brain heart lungs and immune cells. Its expression in these tissues indicates an important regulatory role in both central and peripheral physiological processes.

Biological function summary

PDE4D plays an important role in the modulation of intracellular cAMP levels impacting processes such as inflammation cognition and cardiac function. It does not operate as part of a larger complex but collaborates with other signaling molecules to influence cellular responses. PDE4D's regulation of cAMP levels directly affects protein kinase A (PKA) leading to alterations in gene expression and cell activity.

Pathways

PDE4D integrates into the cAMP signaling and inflammatory pathways impacting various cellular responses. In the cAMP signaling pathway it partners with other PDEs and signaling proteins such as PKA which phosphorylates target proteins affecting cellular function. In inflammatory pathways PDE4D modulates immune cell activity by altering the cAMP-mediated inhibition of pro-inflammatory cytokine production linking it to inflammation-related responses.

PDE4D has associations with conditions such as asthma and ischemic stroke. In asthma PDE4D regulates cAMP levels in lung cells affecting bronchial constriction and inflammation. In ischemic stroke alterations in PDE4D activity influence vascular function by changing cAMP dynamics in vascular smooth muscle cells. Within these disorders PDE4D interacts with proteins like cytokines and COX-2 which also play parts in inflammatory pathways and vascular responses.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

See full target information PDE4D

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文献 (17)

Recent publications for all applications. Explore the full list and refine your search

Clinical and translational medicine 15:e70189 PubMed39956959

2025

5-hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target.

Applications

Unspecified application

Species

Unspecified reactive species

Nuo Xu,Zhaoya Gao,Deyan Wu,Hangyu Chen,Zijian Zhang,Lei Zhang,Yuchen Wang,Xuyang Lu,Xu Yao,Xuelan Liu,Yi-You Huang,Meiying Qiu,Sen Wang,Jinqiang Liang,Can Mao,Feng Zhang,Huimin Xu,Yujiao Wang,Xian Li,Zhexin Chen,Dandan Huang,Jingyi Shi,Wensheng Huang,Fuming Lei,Zeruo Yang,Long Chen,Chuan He,Haichuan Zhu,Hai-Bin Luo,Jin Gu,Jian Lin

The FEBS journal 292:3360-3377 PubMed39673076

2024

Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Yan Sin,Aoife Giblin,Aleksandra Judina,Punchita Rujirachaivej,Laura G Corral,Eliza Glennon,Zhi Xian Tai,Tian Feng,Eduardo Torres,Alina Zorn,Julia Gorelik,Elka Kyurkchieva,Pa Thai Yenchitsomanus,Cathy Swindlehurst,Kyle Chan,David Stirling,George S Baillie

The international journal of neuropsychopharmacology 27: PubMed39099166

2024

Identification of Phosphodiesterase-7A (PDE7A) as a Novel Target for Reducing Ethanol Consumption in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ran Wei,Fangjiao Zong,Jiahao Dong,Wei Zhao,Fangfang Zhang,Wei Wang,Shuang Zhao,Ziqi Wang,Fang Zhang,Han-Ting Zhang

Signal transduction and targeted therapy 9:74 PubMed38528022

2024

SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl concentration.

Applications

Unspecified application

Species

Unspecified reactive species

Jian-Bang Xu,Wei-Jie Guan,Yi-Lin Zhang,Zhuo-Er Qiu,Lei Chen,Xiao-Chun Hou,Junqing Yue,Yu-Yun Zhou,Jie Sheng,Lei Zhao,Yun-Xin Zhu,Jing Sun,Jincun Zhao,Wen-Liang Zhou,Nan-Shan Zhong

Cardiovascular research 120:273-285 PubMed38099489

2023

Remodelling of cAMP dynamics within the SERCA2a microdomain in heart failure with preserved ejection fraction caused by obesity and type 2 diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Lai,Susanne S Hille,Hariharan Subramanian,Robert Wiegmann,Pia Roser,Oliver J Müller,Viacheslav O Nikolaev,Kirstie A De Jong

ESC heart failure 11:541-549 PubMed37964758

2023

Multimodal characterization of dilated cardiomyopathy: Geno- And Phenotyping of PrImary Cardiomyopathy (GrAPHIC).

Applications

Unspecified application

Species

Unspecified reactive species

Laura Keil,Filip Berisha,Stella Ritter,Johanna Skibowski,Hariharan Subramanian,Viacheslav O Nikolaev,Christian Kubisch,Rixa Woitschach,Larissa Fabritz,Raphael Twerenbold,Stefan Blankenberg,Sören Weidemann,Tanja Zeller,Paulus Kirchhof,Daniel Reichart,Christina Magnussen

Cells 11: PubMed36291124

2022

Compartmentation of cGMP Signaling in Induced Pluripotent Stem Cell Derived Cardiomyocytes during Prolonged Culture.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Faleeva,Ivan Diakonov,Prashant Srivastava,Masoud Ramuz,Gaia Calamera,Kjetil Wessel Andressen,Nadja Bork,Lorenza Tsansizi,Marie-Victoire Cosson,Andreia Sofia Bernardo,Viacheslav Nikolaev,Julia Gorelik

Experimental & molecular medicine 54:1201-1213 PubMed35999453

2022

Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Ran Gao,Wenjun Guo,Tianfei Fan,Junling Pang,Yangfeng Hou,Xiaohang Feng,Bolun Li,Weipeng Ge,Tianhui Fan,Tiantian Zhang,Jiakai Lu,He Jing,Mu Jin,Chen Yan,Jing Wang

Frontiers in physiology 13:933963 PubMed35837016

2022

Loss of Unconventional Myosin VI Affects cAMP/PKA Signaling in Hindlimb Skeletal Muscle in an Age-Dependent Manner.

Applications

Unspecified application

Species

Unspecified reactive species

Lilya Lehka,Dominika Wojton,Małgorzata Topolewska,Vira Chumak,Łukasz Majewski,Maria Jolanta Rędowicz

British journal of pharmacology 179:4078-4091 PubMed35362097

2022

Synergistic effects of two naturally occurring iridoids in eliciting a rapid antidepressant action by up-regulating hippocampal PACAP signalling.

Applications