AB171749

重组Anti-PDE4D抗体[EPR11823-29]

Anti-PDE4D antibody [EPR11823-29]

RabMAb
Recombinant
了解详情

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(3 Publications)

Rabbit Recombinant Monoclonal PDE4D antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

查看别名

DPDE3, PDE4D, PDE43, cAMP-specific phosphodiesterase 4D

1 Images

Supplier Data

Western blot - Anti-PDE4D antibody [EPR11823-29] (AB171749)

All lanes:

Anti-cardiac Troponin I antibody (<a href='/products/unavailable/cardiac-troponin-i-antibody-ab1000'>ab1000</a>) at 1/171749 dilution

Lane 1:

Human fetal heart lysate at 10 µg

Lane 2:

Human fetal brain lysate at 10 µg

Lane 3:

K562 cell lysate at 10 µg

Predicted band size: 91 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-PDE4D antibody [EPR11823-29] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR11823-29

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯度

Tissue culture supernatant

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Phosphodiesterase 4D (PDE4D) is an enzyme that hydrolyzes cyclic AMP (cAMP) to its inactive form AMP controlling important cellular signaling pathways. It is part of the large PDE family and sometimes referred to as DPDE1. With a molecular weight of approximately 93 kDa PDE4D is widely expressed in the brain heart lungs and immune cells. Its expression in these tissues indicates an important regulatory role in both central and peripheral physiological processes.

Biological function summary

PDE4D plays an important role in the modulation of intracellular cAMP levels impacting processes such as inflammation cognition and cardiac function. It does not operate as part of a larger complex but collaborates with other signaling molecules to influence cellular responses. PDE4D's regulation of cAMP levels directly affects protein kinase A (PKA) leading to alterations in gene expression and cell activity.

Pathways

PDE4D integrates into the cAMP signaling and inflammatory pathways impacting various cellular responses. In the cAMP signaling pathway it partners with other PDEs and signaling proteins such as PKA which phosphorylates target proteins affecting cellular function. In inflammatory pathways PDE4D modulates immune cell activity by altering the cAMP-mediated inhibition of pro-inflammatory cytokine production linking it to inflammation-related responses.

PDE4D has associations with conditions such as asthma and ischemic stroke. In asthma PDE4D regulates cAMP levels in lung cells affecting bronchial constriction and inflammation. In ischemic stroke alterations in PDE4D activity influence vascular function by changing cAMP dynamics in vascular smooth muscle cells. Within these disorders PDE4D interacts with proteins like cytokines and COX-2 which also play parts in inflammatory pathways and vascular responses.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

See full target information PDE4D

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

The FEBS journal 292:3360-3377 PubMed39673076

2024

Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Yan Sin,Aoife Giblin,Aleksandra Judina,Punchita Rujirachaivej,Laura G Corral,Eliza Glennon,Zhi Xian Tai,Tian Feng,Eduardo Torres,Alina Zorn,Julia Gorelik,Elka Kyurkchieva,Pa Thai Yenchitsomanus,Cathy Swindlehurst,Kyle Chan,David Stirling,George S Baillie

Cellular and molecular life sciences : CMLS 80:178 PubMed37306762

2023

Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology.

Applications

Unspecified application

Species

Unspecified reactive species

Dean Paes,Melissa Schepers,Emily Willems,Ben Rombaut,Assia Tiane,Yevgeniya Solomina,Amy Tibbo,Connor Blair,Elka Kyurkchieva,George S Baillie,Roberta Ricciarelli,Chiara Brullo,Ernesto Fedele,Olga Bruno,Daniel van den Hove,Tim Vanmierlo,Jos Prickaerts

Diagnostics (Basel, Switzerland) 11: PubMed34063765

2021

Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence.

Applications

Unspecified application

Species

Unspecified reactive species

Ombretta Repetto,Federica Lovisa,Caterina Elia,Daniel Enderle,Filippo Romanato,Salvatore Buffardi,Alessandra Sala,Marta Pillon,Agostino Steffan,Roberta Burnelli,Lara Mussolin,Maurizio Mascarin,Valli De Re

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-PDE4D抗体[EPR11823-29]