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AB126213

Anti-PDCD5抗体

Anti-PDCD5 antibody

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Rabbit Polyclonal PDCD5 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PDCD5 aa 1-100.

查看别名

TFAR19, PDCD5, Programmed cell death protein 5, TF-1 cell apoptosis-related protein 19, Protein TFAR19

2 Images
Western blot - Anti-PDCD5 antibody (AB126213)
  • WB

Unknown

Western blot - Anti-PDCD5 antibody (AB126213)

15% SDS PAGE

All lanes:

Western blot - Anti-PDCD5 antibody (ab126213) at 1/1000 dilution

All lanes:

A549 whole cell lysate at 30 µg

Predicted band size: 14 kDa

false

Immunocytochemistry/ Immunofluorescence - Anti-PDCD5 antibody (AB126213)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PDCD5 antibody (AB126213)

ab126213, at a 1/500 dilution, staining PDCD5 in methanol fixed HeLa cells by Immunofluorescence.
Image 2 (lower panel) shows costaining with Hoechst 33342.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

Recombinant Fragment Protein within Human PDCD5 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

O14737

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500.00000 - 1/3000.00000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100.00000 - 1/500.00000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The Programmed Cell Death Protein 5 (PDCD5) also known as TFAR19 is a protein with a molecular mass of about 14 kDa. This protein is expressed widely in human tissues with high levels seen in heart liver skeletal muscle lung and pancreas. Its main role is in promoting programmed cell death or apoptosis by interacting directly with apoptotic molecules. PDCD5 translocates quickly to the nucleus in cells undergoing apoptosis indicating its direct involvement.
Biological function summary

PDCD5 assists in apoptosis by acting as an activator of this cell death mechanism. It is not part of a known protein complex but plays an essential role in enhancing the process of programmed cell death. Researchers have observed a connection between PDCD5 and p53 a well-studied tumor suppressor protein suggesting that PDCD5 may amplify p53-mediated apoptotic responses. This interaction highlights the impact of PDCD5 in cell cycle regulation and stress responses pointing to its potential as a therapeutic target in controlling abnormal cell proliferation.

Pathways

PDCD5 plays a role in apoptosis and DNA damage response pathways. It supports the p53 pathway which is important for preventing tumor formation by slowing down or stopping the cell cycle to allow DNA repair or to induce apoptosis if DNA damage is irreversible. PDCD5 may also interact with proteins like P53 promoting their apoptotic activities. Additionally through the involvement in p53 pathways PDCD5 potentially contributes to maintaining genome integrity.

PDCD5 links to cancer and neurodegenerative conditions. Its expression levels often decrease in various cancers highlighting its role in suppressing tumor growth. When PDCD5 expression is lower cells might evade apoptosis leading to tumor proliferation. In some neurodegenerative disorders altered PDCD5 function or expression has been observed suggesting its involvement in neuronal cell death. PDCD5's interaction with proteins like p53 in these conditions points to its relevance for understanding and potentially managing cancer and neurodegeneration.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

May function in the process of apoptosis.
See full target information PDCD5
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详情请参阅我们的条款与条件。
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