AB154557

Anti-PCTAIRE3抗体

Name: PCTAIRE3抗体 (ab154557)| Abcam中文官网
Brand: Abcam Limited
SKU: AB154557
Price: 4744 CNY
Availability: InStock

Anti-PCTAIRE3 antibody

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(2 Publications)

Rabbit Polyclonal PCTAIRE3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CDK18 aa 150-500.

查看别名

PCTAIRE3, PCTK3, CDK18, Cyclin-dependent kinase 18, Cell division protein kinase 18, PCTAIRE-motif protein kinase 3, Serine/threonine-protein kinase PCTAIRE-3

1 Images

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Western blot - Anti-PCTAIRE3 antibody (AB154557)

7.5% SDS PAGE

All lanes:

Western blot - Anti-PCTAIRE3 antibody (ab154557) at 1/1000 dilution

All lanes:

HepG2 whole cell lysate at 30 µg

Predicted band size: 54 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Fragment Protein within Human CDK18 aa 150-500. The exact immunogen used to generate this antibody is proprietary information.

Q07002

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PCTAIRE3 also known as cyclin-dependent kinase 18 (CDK18) is a serine/threonine protein kinase. It has a molecular mass of approximately 37 kDa. Typically this protein is found in high amounts in the testis brain and pancreas. PCTAIRE3 plays a role in cellular processes by acting as a regulatory kinase. It is involved in phosphorylating specific substrates which is important for its function.

Biological function summary

PCTAIRE3 contributes to cell cycle regulation and neuronal signaling. It is a part of the cyclin-dependent kinase (CDK) family which is responsible for controlling progression through the cell cycle. These kinases often form complexes with cyclins to perform their regulatory roles effectively. The protein's expression in neuronal tissues suggests a role in synaptic plasticity or neuronal development though exact mechanisms need further study.

Pathways

PCTAIRE3 participates in the cell cycle and signal transduction pathways. It interacts with other CDKs and cyclins to help coordinate the cell cycle particularly in the G2/M transition. PCTAIRE3's involvement with these pathways links it to proteins like cyclin B and CDK1. Additionally its presence in signal transduction pathways connects it to various molecular signals which influence cellular responses and decisions.

Mutations or dysregulation of PCTAIRE3 have been implicated in cancers and neurodevelopmental disorders. In cancer aberrant expression of CDKs can lead to uncontrolled cell proliferation. PCTAIRE3 has been associated with specific tumors where it may interact with proteins like p53 that are critical in controlling the cell cycle and tumor suppression. In neurodevelopmental disorders variations in PCTAIRE3 might influence synaptic signaling contributing to conditions such as schizophrenia though research on these connections remains ongoing.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May play a role in signal transduction cascades in terminally differentiated cells.

See full target information CDK18

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 49:4689-4704 PubMed33836087

2021

Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Qinghai Zhang,Xiao He,Shihao Yao,Tianxiang Lin,Luwen Zhang,Danni Chen,Chao Chen,Qingxian Yang,Feng Li,Yi-Min Zhu,Min-Xin Guan

Journal of cellular and molecular medicine 24:10151-10165 PubMed32715641

2020

CXXC finger protein 4 inhibits the CDK18-ERK1/2 axis to suppress the immune escape of gastric cancer cells with involvement of ELK1/MIR100HG pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Li,Dongfang Ge,Pengfei Li,Fangyong Hu,Junfeng Chu,Xiaojun Chen,Wenbo Song,Ali Wang,Guangyu Tian,Xiang Gu

View all publications

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Anti-PCTAIRE3抗体

Anti-PCTAIRE3 antibody

Western blot - Anti-PCTAIRE3 antibody (AB154557)