AB128815

Anti-PCDH17抗体

Name: PCDH17抗体 (ab128815)| Abcam中文官网
Brand: Abcam Limited
SKU: AB128815
Price: 4744 CNY
Availability: InStock

Anti-PCDH17 antibody

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(6 Publications)

Goat Polyclonal PCDH17 antibody. Suitable for WB and reacts with Mouse samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human PCDH17 aa 1050 to C-terminus.

查看别名

PCDH68, PCH68, PCDH17, Protocadherin-17, Protocadherin-68

1 Images

Unknown

Western blot - Anti-PCDH17 antibody (AB128815)

All lanes:

Western blot - Anti-PCDH17 antibody (ab128815) at 0.2 µg/mL

All lanes:

Mouse fetal brain lysate in RIPA buffer at 35 µg

Predicted band size: 126 kDa

Observed band size: 150 kDa

true

Exposure time: 1hr

关键信息

宿主种属

Goat

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse

应用

applications

免疫原

Synthetic Peptide within Human PCDH17 aa 1050 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O14917

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.3 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chinese hamster": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

存储溶液

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PCDH17 also known as protocadherin-17 is a protein involved in cell-cell adhesion. This protein is a member of the protocadherin family which is part of the cadherin superfamily. It has a molecular weight of approximately 120 kDa. PCDH17 contains cadherin-like domains which facilitate calcium-dependent cell adhesion. The protein is mainly expressed in the brain especially in regions associated with memory and learning such as the hippocampus and the cerebral cortex.

Biological function summary

Protocadherin-17 influences neural circuit formation and maintenance. It acts as a member of trans-synaptic complexes that modulate the connectivity and signaling efficiency between neurons. This protein plays a important role in the reorganization of synaptic connections during neuronal development and in response to environmental stimuli. Studies indicate its contribution to the stabilization of cell-cell interactions necessary for maintaining synaptic specificity.

Pathways

Protocadherin-17 integrates into complex neural pathways involved in synaptic plasticity and neurodevelopment. It interacts with other members of the cadherin family like N-cadherin to modulate synaptic structures and signaling cascades. PCDH17 potentially influences pathways related to calcium signaling which are essential for various neural processes.

Alterations in protocadherin-17 expression have been associated with neurological conditions such as epilepsy and schizophrenia. Abnormal expression or mutations in this protein may disrupt synaptic connectivity and function contributing to the pathophysiology of these disorders. Connections between PCDH17 and other cadherins as well as neurotransmitter receptors may influence disease states where aberrant signaling and cell adhesion play roles.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Potential calcium-dependent cell-adhesion protein.

See full target information PCDH17

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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 16:36 PubMed39837826

2025

PCDH17 induces colorectal cancer metastasis by destroying the vascular endothelial barrier.

Applications

Unspecified application

Species

Unspecified reactive species

Fengyun Dong,Pinghui Zhou,Feifei Kong,Sijie Cao,Xiaozao Pan,Shujing Cai,Xinke Chen,Sen Wang,Na Li,Baoyu He,Rou Zhao,Bin Zhang,Qingli Bie

Zoological research 45:535-550 PubMed38747058

2024

PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton, modulating emotional behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Laidong Yu,Fangfang Zeng,Mengshu Fan,Kexuan Zhang,Jingjing Duan,Yalu Tan,Panlin Liao,Jin Wen,Chenyu Wang,Meilin Wang,Jialong Yuan,Xinxin Pang,Yan Huang,Yangzhou Zhang,Jia-Da Li,Zhuohua Zhang,Zhonghua Hu

Aging 16:7578-7595 PubMed38568089

2024

Establishment and verification of a prognostic model based on coagulation and fibrinolysis-related genes in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Meng Fan,Le Lu,Hao Shang,Yuxuan Lu,Yi Yang,Xiuyan Wang,Hongwei Lu

Human molecular genetics 32:1193-1207 PubMed36370042

2022

Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation.

Applications

Unspecified application

Species

Unspecified reactive species

Marc R Benoit,Mabintou Darboe,Brati Das,Yingying Ge,John Zhou,Annie Yao,Wanxia He,Riqiang Yan,Xiangyou Hu

Signal transduction and targeted therapy 4:53 PubMed31815010

2019

PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death.

Applications

Unspecified application

Species

Unspecified reactive species

Shuiping Liu,Haoming Lin,Da Wang,Qiang Li,Hong Luo,Guoxiong Li,Xiaohui Chen,Yongqiang Li,Peng Chen,Bingtao Zhai,Wengang Wang,Ruonan Zhang,Bi Chen,Mingming Zhang,Xuemeng Han,Qiujie Li,Liuxi Chen,Ying Liu,Xiaying Chen,Guohua Li,Yu Xiang,Ting Duan,Jiao Feng,Jianshu Lou,Xingxing Huang,Qin Zhang,Ting Pan,Lili Yan,Ting Jin,Wenzheng Zhang,Lvjia Zhuo,Yitian Sun,Tian Xie,Xinbing Sui

Auris, nasus, larynx 46:583-592 PubMed30454973

2018

MiR-196b affects the progression and prognosis of human LSCC through targeting PCDH-17.

Applications

Unspecified application

Species

Unspecified reactive species

Min Luo,Gang Sun,Jing-Wu Sun

View all publications

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Anti-PCDH17抗体

Anti-PCDH17 antibody

Western blot - Anti-PCDH17 antibody (AB128815)