Anti-PBR抗体(ab118913)
Key features and details
- Goat polyclonal to PBR
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-PBR抗体
参阅全部 PBR 一抗 -
描述
山羊多克隆抗体to PBR -
宿主
Goat -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rat
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免疫原
Synthetic peptide corresponding to Mouse PBR aa 150-250 (C terminal) conjugated to keyhole limpet haemocyanin.
Database link: P50637 -
阳性对照
- Mouse Spleen lysate; Human Adipose, Renal Tubules and Squamous Epithelium tissues.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading... -
纯度
Protein G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab118913于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 18 kDa (predicted molecular weight: 19 kDa).
|
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| IHC-P |
Use a concentration of 3.75 µg/ml.
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| 说明 |
|---|
|
WB
Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 18 kDa (predicted molecular weight: 19 kDa). |
|
IHC-P
Use a concentration of 3.75 µg/ml. |
靶标
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功能
Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells. -
组织特异性
Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids. -
序列相似性
Belongs to the TspO/BZRP family. -
细胞定位
Mitochondrion membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 706 Human
- Entrez Gene: 12257 Mouse
- Entrez Gene: 24230 Rat
- Omim: 109610 Human
- SwissProt: B1AH88 Human
- SwissProt: P30536 Human
- SwissProt: P50637 Mouse
- SwissProt: P16257 Rat
see all -
别名
- Benzodiazapine receptor (peripheral) antibody
- Benzodiazepine peripheral binding site antibody
- BPBS antibody
see all
图片
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Western blot - Anti-PBR antibody (ab118913)Anti-PBR antibody (ab118913) at 0.5 µg/ml + Mouse Spleen lysate (in RIPA buffer) at 35 µg
Developed using the ECL technique.
Predicted band size: 19 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PBR antibody (ab118913)ab118913, at 3.75 µg/ml, staining PBR in Formalin-fixed, Paraffin-embedded Human Adipose tissue by Immunohistochemistry. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PBR antibody (ab118913)ab118913, at 3.75 µg/ml, staining PBR in Formalin-fixed, Paraffin-embedded Human Renal tubules tissue by Immunohistochemistry. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PBR antibody (ab118913)ab118913, at 3.75 µg/ml, staining PBR in Formalin-fixed, Paraffin-embedded Human Squamous Epithelium tissue by Immunohistochemistry.
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab118913 被引用在 5 文献中.
- Pradhan AK et al. Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer's disease. Transl Psychiatry 13:332 (2023). PubMed: 37891168
- Loth MK et al. A Novel Interaction of Translocator Protein 18 kDa (TSPO) with NADPH Oxidase in Microglia. Mol Neurobiol 57:4467-4487 (2020). PubMed: 32743737
- Tournier BB et al. Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer's Disease. J Alzheimers Dis 77:1043-1056 (2020). PubMed: 32804124
- Nack A et al. Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models. Cells 8:N/A (2019). PubMed: 30696113
- Mirzaei N et al. In vivo imaging of microglial activation by positron emission tomography with [(11)C]PBR28 in the 5XFAD model of Alzheimer's disease. Glia 64:993-1006 (2016). PubMed: 26959396