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AB212694

Anti-PAX6抗体[PAX6/498] - BSA and Azide free

Anti-PAX6 antibody [PAX6/498] - BSA and Azide free

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(1 Publication)

Mouse Monoclonal PAX6 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PAX6 aa 1-300.

查看别名

AN2, PAX6, Paired box protein Pax-6, Aniridia type II protein, Oculorhombin

1 Images
Western blot - Anti-PAX6 antibody [PAX6/498] - BSA and Azide free (AB212694)
  • WB

Supplier Data

Western blot - Anti-PAX6 antibody [PAX6/498] - BSA and Azide free (AB212694)

All lanes:

Western blot - Anti-PAX6 antibody [PAX6/498] - BSA and Azide free (ab212694) at 1 µg/mL

All lanes:

Human cerebellum lysate

Predicted band size: 47 kDa

false

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

PAX6/498

亚型

IgG1

轻链类型

kappa

不含载体蛋白

Yes

反应种属

Human

应用

WB

applications

免疫原

Recombinant Fragment Protein within Human PAX6 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

P26367

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Zebrafish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A/G
纯化说明
ab212694 is purified from Bioreactor Concentrate by Protein A/G.
存储溶液
pH: 7.2 - 7.4 Constituents: PBS
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The PAX6 protein also known as paired box 6 is a transcription factor involved in the development of eyes and neural tissues. It consists of a paired domain and a homeodomain collectively giving a molecular weight of approximately 48 kDa. This protein is highly expressed in developing ocular and central nervous tissues where it controls the expression of genes necessary for proper development. PAX6 is a widely studied marker in developmental biology due to its critical role in cellular differentiation and patterning processes.
Biological function summary

PAX6 acts as an important regulator in eye and neural development functioning alone and as part of larger complexes with other transcription factors. This role ensures the correct formation of ocular structures including the lens retina and cornea and neural elements by activating downstream targets important for cell fate decisions. The PAX6 protein intricately influences the genetic circuits that guide stem cell differentiation highlighting its importance in embryogenesis and organogenesis.

Pathways

PAX6 is pivotal in the Wnt signaling pathway and retinoic acid signaling. Its interaction within the Wnt pathway orchestrates vital developmental processes including those of eye morphogenesis and brain patterning. The protein collaborates with other transcriptional regulators such as SOX2 and EYA1 within these pathways facilitating the complex network of signals necessary for organ development and cellular identity specification.

PAX6 mutations have strong associations with aniridia and congenital eye malformations. Mutations in PAX6 disrupt the transcriptional regulation required for eye development often resulting in severe vision defects and structural anomalies. The intracacy of its involvement extends to disorders like Wilms' tumor wherein its altered expression or function in conjunction with proteins such as WT1 may contribute to oncogenesis. Scientists frequently use PAX6 staining to investigate these conditions and better understand their molecular underpinnings.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity).
See full target information PAX6
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 9:18096 PubMed31792260

2019

BioSphincters to treat Fecal Incontinence in Nonhuman Primates.

Applications

Unspecified application

Species

Unspecified reactive species

Prabhash Dadhich,Jaime L Bohl,Riccardo Tamburrini,Elie Zakhem,Christie Scott,Nancy Kock,Erin Mitchell,John Gilliam,Khalil N Bitar
View all publications
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