Anti-PATJ抗体(ab134784)
Key features and details
- Goat polyclonal to PATJ
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-PATJ抗体 -
描述
山羊多克隆抗体to PATJ -
宿主
Goat -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Rabbit, Horse, Chicken, Cow, Dog, Turkey, Chimpanzee, Macaque monkey, Common marmoset, Orangutan, Bat -
免疫原
Synthetic peptide:
PENPATDKLQVLQ-C
, corresponding to N terminal amino acids 2-14 of Human PATJ (NP_795352.2). -
阳性对照
- Human testis tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 99% Tris buffered saline -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab134784于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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IHC-P
Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). -
组织特异性
Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain. -
序列相似性
Contains 1 L27 domain.
Contains 10 PDZ (DHR) domains. -
结构域
The L27 domain (also called Maguk recruitment domain) is required for interaction with MPP5 and CRB3, and MPP5 localization to tight junctions.
The PDZ domain 6 mediates interaction with the C-terminus of TJP3 and is crucial for localization to the tight junctions. The PDZ domain 8 interacts with CLDN1 but is not required for proper localization. -
细胞定位
Cell junction, tight junction. Apical cell membrane. Cytoplasm, perinuclear region. Cell membrane. Localized in the paranodal region of myelinating Schwann cells (By similarity). Membrane-associated. Localizes to tight junctions in epithelial cells (PubMed:22006950). Also found at the apical plasma membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 424682 Chicken
- Entrez Gene: 536993 Cow
- Entrez Gene: 479550 Dog
- Entrez Gene: 100070486 Horse
- Entrez Gene: 10207 Human
- Omim: 603199 Human
- SwissProt: Q8NI35 Human
- Unigene: 478125 Human
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别名
- Channel interacting PDZ domain protein antibody
- Cipp antibody
- FLJ26982 antibody
see all
图片
数据表及文件
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Datasheet download
文献 (0)
ab134784 尚未被引用在任何文献中。