JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB200395

Anti-PARP8抗体- C-terminal

Anti-PARP8 antibody - C-terminal

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal PARP8 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Protein mono-ADP-ribosyltransferase PARP8.

查看别名

Protein mono-ADP-ribosyltransferase PARP8, ADP-ribosyltransferase diphtheria toxin-like 16, Poly [ADP-ribose] polymerase 8, ARTD16, PARP-8, PARP8

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PARP8 antibody - C-terminal (AB200395)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PARP8 antibody - C-terminal (AB200395)

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling PARP8 with ab200395 at 1/40 dilution.

Western blot - Anti-PARP8 antibody - C-terminal (AB200395)
  • WB

Supplier Data

Western blot - Anti-PARP8 antibody - C-terminal (AB200395)

All lanes:

Western blot - Anti-PARP8 antibody - C-terminal (ab200395) at 1/200 dilution

All lanes:

Hela cell lysate at 40 µg

Predicted band size: 95 kDa

true

Exposure time: 3min

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human Protein mono-ADP-ribosyltransferase PARP8. The exact immunogen used to generate this antibody is proprietary information.

Q8N3A8

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PARP8 also called Poly (ADP-ribose) polymerase family member 8 is a protein with a molecular mass of about 75 kDa. It belongs to the PARP family involved in catalyzing the transfer of ADP-ribose units from NAD+ to target proteins. PARP8 is found in various tissues including the brain liver and lungs. It plays a role in protein interactions mediating cellular processes and signaling.
Biological function summary

Four distinct processes involve PARP8's actions in regulating transcription processes genome stability and DNA damage response. PARP8 may interact in complexes that further influence cellular responses to stress. It manages chromatin structure through poly-ADP-ribosylation affecting gene expression and cellular resilience against genotoxic stressors.

Pathways

A couple of critical pathways engage PARP8's role in managing cellular equilibrium. The DNA damage response (DDR) pathway includes PARP8 collaborating with proteins like ATM and ATR which are involved in sensing DNA damage and promoting repair mechanisms. Additionally the transcriptional regulation pathway involves PARP8 affecting gene expression by modulating chromatin structure and interacting with transcription factors.

Several pathological conditions implicate PARP8 through its regulatory functions in cellular stress responses. Cancer is notable where abnormal PARP8 activity could disrupt genome stability and facilitate tumor progression. Inflammatory diseases also show connections with PARP8 activity involving its interaction with other PARP family members like PARP1 modulating inflammatory responses. Alterations in these pathways may contribute to understanding disease mechanisms and therapeutic interventions.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
See full target information Protein mono-ADP-ribosyltransferase PARP8
style
left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 23:1029 PubMed41029776

2025

Screening and experimental study of potential biomarkers for ulcerative colitis based on weighted gene co-expression network analysis and machine learning.

Applications

Unspecified application

Species

Unspecified reactive species

Zepeng Chen,Xingchen Wang,Changfang Xiao,Yongqing Cao

The Journal of biological chemistry 300:105695 PubMed38301894

2024

The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Kazuo Asanoma,Hiroshi Yagi,Ichiro Onoyama,Lin Cui,Emiko Hori,Minoru Kawakami,Shoji Maenohara,Kazuhisa Hachisuga,Hiroshi Tomonobe,Keisuke Kodama,Masafumi Yasunaga,Tatsuhiro Ohgami,Kaoru Okugawa,Hideaki Yahata,Hiroyuki Kitao,Kiyoko Kato
View all publications
style
left-column
style
left-column
style
right-column

搭配使用产品

Primary Antibodies

AB32064

Anti-Cleaved PARP1 antibody [E51]

RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cleaved PARP1 antibody [E51] (AB32064)

  • 4
  • 18
Primary Antibodies

AB70800

Anti-ARTD10 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARTD10 antibody (AB70800)

  • 0
  • 0
Primary Antibodies

AB203669

Anti-DNase gamma antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DNase gamma antibody (AB203669)

  • 0
  • 0
Primary Antibodies

AB248248

Anti-AIPL1 antibody [EPR7711] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-AIPL1 antibody [EPR7711] - BSA and Azide free (AB248248)

  • 0
  • 0

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com