Anti-PAR2抗体[SAM11] (ab184673)
Key features and details
- Mouse monoclonal [SAM11] to PAR2
- Suitable for: IHC-Fr, WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG2a
概述
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产品名称
Anti-PAR2抗体[SAM11]
参阅全部 PAR2 一抗 -
描述
小鼠单克隆抗体[SAM11] to PAR2 -
宿主
Mouse -
经测试应用
适用于: IHC-Fr, WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Full length protein corresponding to Human PAR2.
Database link: P55085 -
表位
ab184673 was mapped to amino acids 37 - 50. -
阳性对照
- Human heart tissue; Mouse 3T3 cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
Constituent: 100% PBS -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
SAM11 -
同种型
IgG2a -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab184673于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-Fr |
Use at an assay dependent concentration.
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|
WB |
1/1000 - 1/2000. Predicted molecular weight: 44 kDa.
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IHC-P | (1) |
1/100.
|
说明 |
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IHC-Fr
Use at an assay dependent concentration. |
WB
1/1000 - 1/2000. Predicted molecular weight: 44 kDa. |
IHC-P
1/100. |
靶标
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功能
Receptor for trypsin and trypsin-like enzymes coupled to G proteins that stimulate phosphoinositide hydrolysis. May have a role in the regulation of vascular tone. -
组织特异性
Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
翻译后修饰
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 2150 Human
- Entrez Gene: 14063 Mouse
- Omim: 600933 Human
- SwissProt: P55085 Human
- SwissProt: P55086 Mouse
- Unigene: 154299 Human
- Unigene: 1614 Mouse
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别名
- Coagulation factor II receptor like 1 antibody
- Coagulation factor II receptor-like 1 antibody
- Coagulation factor II thrombin receptor like 1 antibody
see all
图片
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All lanes : Anti-PAR2 antibody [SAM11] (ab184673) at 1/1000 dilution
Lane 1 : Mouse 3T3 cell lysate at 10 µg
Lane 2 : Mouse 3T3 cell lysate at 20 µg
Lane 3 : BSA control
Predicted band size: 44 kDa -
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human heart tissue labeling PAR2 with ab184673 at 10μg/ml.
数据表及文件
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SDS download
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Datasheet download
文献 (8)
ab184673 被引用在 8 文献中.
- Francischetti IMB et al. Neutrophil and Eosinophil Extracellular Traps in Hodgkin Lymphoma. Hemasphere 5:e633 (2021). PubMed: 34485830
- Pierre O et al. Calcium Increase and Substance P Release Induced by the Neurotoxin Brevetoxin-1 in Sensory Neurons: Involvement of PAR2 Activation through Both Cathepsin S and Canonical Signaling. Cells 9:N/A (2020). PubMed: 33348659
- Wypasek E et al. Effects of rivaroxaban and dabigatran on local expression of coagulation and inflammatory factors within human aortic stenotic valves. Vascul Pharmacol 130:106679 (2020). PubMed: 32387621
- Hoffman S et al. Fecal Proteases from Pouchitis Patients Activate Protease Activating Receptor-2 to Disrupt the Epithelial Barrier. J Crohns Colitis N/A:N/A (2019). PubMed: 31056700
- Li TZ et al. Protease-activated receptor-2 regulates glial scar formation via JNK signaling. Physiol Res N/A:N/A (2019). PubMed: 30628825
- Lianto P et al. Quail egg homogenate alleviates food allergy induced eosinophilic esophagitis like disease through modulating PAR-2 transduction pathway in peanut sensitized mice. Sci Rep 8:1049 (2018). PubMed: 29348584
- DuMont AL & Cianciotto NP Stenotrophomonas maltophilia Serine Protease StmPr1 Induces Matrilysis, Anoikis, and Protease-Activated Receptor 2 Activation in Human Lung Epithelial Cells. Infect Immun 85:N/A (2017). PubMed: 28893914
- Villari A et al. Apixaban Enhances Vasodilatation Mediated by Protease-Activated Receptor 2 in Isolated Rat Arteries. Front Pharmacol 8:480 (2017). PubMed: 28769809