AB7205

Anti-PAI1抗体

Name: PAI1抗体 (ab7205)| Abcam中文官网
Brand: Abcam Limited
SKU: AB7205
Price: 4903 CNY
Availability: InStock

Anti-PAI1 antibody

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(10 Publications)

Rabbit Polyclonal PAI1 antibody. Suitable for WB and reacts with Rat samples. Cited in 10 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Serpine1.

查看别名

Pai1, Planh1, Serpine1, Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1

1 Images

Unknown

Western blot - Anti-PAI1 antibody (AB7205)

Rat PAI1 detected by Western blot on Day 3 in a glomerular nephritis model.

All lanes:

Western blot - Anti-PAI1 antibody (ab7205) at 1/1000 dilution

Predicted band size: 45 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat

应用

applications

免疫原

Recombinant Full Length Protein corresponding to Rat Serpine1.

P20961

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 6.5 Preservative: 0.1% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).

See full target information Serpine1

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文献 (10)

Recent publications for all applications. Explore the full list and refine your search

Mediators of inflammation 2021:5599364 PubMed34456628

2021

p300/Sp1-Mediated High Expression of p16 Promotes Endothelial Progenitor Cell Senescence Leading to the Occurrence of Chronic Obstructive Pulmonary Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Zhihui He,Huaihuai Peng,Min Gao,Guibin Liang,Menghao Zeng,Xuefeng Zhang

Brazilian journal of medical and biological resear 53:e8826 PubMed32901686

2020

Decreased expression of microRNA-17 in hippocampal tissues and blood from mice with depression up-regulates the expression of PAI-1 mRNA and protein.

Applications

Unspecified application

Species

Unspecified reactive species

Min Lv,Jing Li,Xinxue Gao,Yurong Hao,Fengxia Zhao

Endocrinology 159:2621-2639 PubMed29788427

2018

Changes in Corticotrope Gene Expression Upon Increased Expression of Peptidylglycine α-Amidating Monooxygenase.

Applications

Unspecified application

Species

Unspecified reactive species

Richard E Mains,Crysten Blaby-Haas,Bruce A Rheaume,Betty A Eipper

Experimental and therapeutic medicine 15:5125-5132 PubMed29805539

2018

MicroRNA-30b protects myocardial cell function in patients with acute myocardial ischemia by targeting plasminogen activator inhibitor-1.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Li,Jie Hu,Xingpeng Chen

Journal of cellular biochemistry 119:4692-4710 PubMed29278662

2018

MicroRNA-335-5p suppresses lower extremity deep venous thrombosis by targeted inhibition of PAI-1 via the TLR4 signalingpathway.

Applications

Unspecified application

Species

Unspecified reactive species

Cui-Xia Bao,Dong-Xia Zhang,Na-Na Wang,Xiang-Kui Zhu,Qi Zhao,Xiao-Lei Sun

FASEB journal : official publication of the Federa 29:4956-67 PubMed26405299

2015

Extracellular matrix-induced Hic-5 expression in glomerular mesangial cells leads to a prosclerotic phenotype independent of TGF-β.

Applications

Unspecified application

Species

Unspecified reactive species

Nick Hornigold,Andrew Mooney

PloS one 8:e67470 PubMed23825664

2013

NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect.

Applications

Species

Unspecified reactive species

Georgios C Stefos,Ulf Soppa,Mara Dierssen,Walter Becker

FEBS letters 586:3317-23 PubMed22819829

2012

N-terminal tyrosine phosphorylation of caveolin-2 negates anti-proliferative effect of transforming growth factor beta in endothelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Britain Abel,Cara Willoughby,Sungchan Jang,Laura Cooper,Leike Xie,Chi Vo-Ransdell,Grzegorz Sowa

The Journal of endocrinology 200:207-21 PubMed19036760

2008

Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells.

Applications

ICC, WB

Species

Mouse, Mouse

Jorge N Artaza,Keith C Norris

The Journal of endocrinology 196:235-49 PubMed18252947

2008

Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Jorge N Artaza,Rajan Singh,Monica G Ferrini,Melissa Braga,James Tsao,Nestor F Gonzalez-Cadavid

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

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For licensing inquiries, please contact partnerships@abcam.com

Anti-PAI1抗体

Anti-PAI1 antibody

Western blot - Anti-PAI1 antibody (AB7205)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

反应性数据

性能和储存信息

形式

纯化工艺

存储溶液

运输条件

推荐的短期储存时间

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

产品实验方案

靶点信息

文献 (10)

Abcam Product Promise

Anti-PAI1抗体

Anti-PAI1 antibody

Western blot - Anti-PAI1 antibody (AB7205)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

替代产品

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Primary Antibodies

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搭配使用产品

Assay Kits

Secondary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

反应性数据

性能和储存信息

形式

纯化工艺

存储溶液

运输条件

推荐的短期储存时间

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

产品实验方案

靶点信息

文献 (10)

Abcam Product Promise