AB181762

Anti-PADI1 / PAD1 抗体

Name: PADI1 / PAD1抗体 (ab181762)| Abcam中文官网
Brand: Abcam Limited
SKU: AB181762
Price: 4606 CNY
Availability: InStock

Anti-PADI1 / PAD1 antibody

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(7 Publications)

Rabbit Polyclonal PADI1 / PAD1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human PADI1.

查看别名

PAD1, PDI1, PADI1, Protein-arginine deiminase type-1, Peptidylarginine deiminase I, Protein-arginine deiminase type I

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PADI1 / PAD1 antibody (AB181762)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PADI1 / PAD1 antibody (AB181762)

Immunohistochemical staining of /human spleen tissue labeling PADL1/PAD1 with ab181762 at 1/200 dilution.

Supplier Data

Western blot - Anti-PADI1 / PAD1 antibody (AB181762)

All lanes:

Western blot - Anti-PADI1 / PAD1 antibody (ab181762) at 1/200 dilution

All lanes:

Human epidermis

Predicted band size: 75 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human PADI1. The exact immunogen used to generate this antibody is proprietary information.

Q9ULC6

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/1000", "IHCP-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PADI1 also known as PAD1 or PADIone is a protein of approximately 74 kDa that belongs to the peptidylarginine deiminase family. It catalyzes the conversion of arginine residues into citrulline in a calcium-dependent manner a process known as citrullination or deimination. The PADI1 expression is mainly in the epidermis hair follicles and other keratinizing tissues. The enzyme requires at least one Ca2+ ion for its activity and often associates with the nucleus and cytoplasm within cells.

Biological function summary

PADI1 plays an important role in modulating structural changes in proteins involved in skin differentiation and hair formation. It is not known to form part of a larger protein complex but instead acts as a standalone enzyme in multiple cellular processes. The citrullination activity of PADI1 significantly affects the structural proteins like keratin and filaggrin influencing keratinocyte terminal differentiation and barrier function of the skin.

Pathways

PADI1 is instrumental in the formation of the epidermal barrier by contributing to the terminal differentiation pathway of keratinocytes. This pathway ensures the proper development and maintenance of the skin layers. It associates with proteins such as keratin and filaggrin during this process. Furthermore PADI1 also links to pathways involved in the regulation of intracellular protein modification impacting the overall protein structure and function in tissues.

PADI1 has been linked to psoriasis and skin cancers. In psoriasis the aberrant expression or regulation of PADI1 can lead to improper protein citrullination affecting skin barrier function and immune responses. Moreover dysregulated activity of PADI1 connects to skin cancer progression through its impact on keratinocyte proliferation and differentiation. Research has shown interactions with other proteins like keratin as part of these disease processes relevant to its role in skin pathology.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Catalyzes the deimination of arginine residues of proteins.

See full target information PADI1

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文献 (7)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40362485

2025

Placental Protein Citrullination Signatures Are Modified in Early- and Late-Onset Fetal Growth Restriction.

Applications

Unspecified application

Species

Unspecified reactive species

Owen R Vaughan,Kasia Maksym,Sara Hillman,Rebecca N Spencer,Mariya Hristova,Anna L David,Sigrun Lange

eNeuro 11: PubMed39542733

2024

Procaine Regulates the STAT3/CCL5 Axis and Inhibits Microglia M1 Polarization to Alleviate Complete Freund's Adjuvant Rats Pain Behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Sun,Kai Zhang,Chen Li,QingDong Wang,Rongjia Zang

International journal of molecular sciences 25: PubMed39456949

2024

Brain-Region-Specific Differences in Protein Citrullination/Deimination in a Pre-Motor Parkinson's Disease Rat Model.

Applications

Unspecified application

Species

Unspecified reactive species

Audrey Mercer,Marco Sancandi,Amy Maclatchy,Sigrun Lange

International journal of molecular sciences 23: PubMed36361903

2022

Differential, Stage Dependent Detection of Peptidylarginine Deiminases and Protein Deimination in Lewy Body Diseases-Findings from a Pilot Study.

Applications

Unspecified application

Species

Unspecified reactive species

Audrey Mercer,Zane Jaunmuktane,Mariya Hristova,Sigrun Lange

International journal of molecular sciences 23: PubMed35955829

2022

A Pilot Study on Peptidylarginine Deiminases and Protein Deimination in Animal Cancers across Vertebrate Species.

Applications

Unspecified application

Species

Unspecified reactive species

Jameel M Inal,Mariya Hristova,Sigrun Lange

International journal of molecular sciences 23: PubMed35563075

2022

Acute Hypoxia Alters Extracellular Vesicle Signatures and the Brain Citrullinome of Naked Mole-Rats ().

Applications

Unspecified application

Species

Unspecified reactive species

Stefania D'Alessio,Hang Cheng,Liam Eaton,Igor Kraev,Matthew E Pamenter,Sigrun Lange

Developmental and comparative immunology 125:104225 PubMed34358577

2021

Post-translational protein deimination signatures in sea lamprey (Petromyzon marinus) plasma and plasma-extracellular vesicles.

Applications

Unspecified application

Species

Unspecified reactive species

Jonathan P Rast,Stefania D'Alessio,Igor Kraev,Sigrun Lange

View all publications

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Anti-PADI1 / PAD1 抗体

Anti-PADI1 / PAD1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PADI1 / PAD1 antibody (AB181762)

Western blot - Anti-PADI1 / PAD1 antibody (AB181762)