JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB243703

Anti-PACS1抗体

Anti-PACS1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal PACS1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PACS1 aa 400 to C-terminus.

查看别名

KIAA1175, PACS1, Phosphofurin acidic cluster sorting protein 1, PACS-1

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)

Formalin-fixed, paraffin-embedded human testis tissue stained for PACS1 using ab243703 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)

Formalin-fixed, paraffin-embedded human lymph node tissue stained for PACS1 using ab243703 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)

Negative control :

Formalin-fixed, paraffin-embedded human liver tissue stained for PACS1 using ab243703 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)

Formalin-fixed, paraffin-embedded human cerebral cortex tissue stained for PACS1 using ab243703 at 1/200 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-PACS1 antibody (AB243703)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-PACS1 antibody (AB243703)

PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells labeling PACS1 (Green) using ab243703 at 4 μg/mL in ICC/IF analysis.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human PACS1 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6VY07

style
left-column

替代产品

Primary Antibodies

AB208171

Anti-PACS1 antibody

Western blot - Anti-PACS1 antibody (AB208171)

  • 0
  • 1

搭配使用产品

Primary Antibodies

AB24609

Anti-Nuclear Pore Complex Proteins antibody [Mab414]

Immunocytochemistry/ Immunofluorescence - Anti-Nuclear Pore Complex Proteins antibody [Mab414] (AB24609)

  • 4
  • 12
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
Primary Antibodies

AB37266

Anti-Giantin antibody [9B6] - Golgi Marker

Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-Giantin antibody [9B6] - Golgi Marker (AB37266)

  • 4
  • 15
Primary Antibodies

AB240636

Anti-Ctip2 antibody [EPR23120-25]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-Ctip2 antibody [EPR23120-25] (AB240636)

  • 5
  • 1
style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PACS1 also known as PACSONE and PACS-1 is a cytosolic sorting protein that plays a role in maintaining intracellular cargo and membrane trafficking. It has a molecular weight of approximately 110 kDa. Expressed in various tissues including brain kidney and liver PACS1 works as a bridge connecting trans-Golgi network (TGN) to endosome trafficking pathways where it helps in targeting proteins for endocytosis and recycling back to the TGN.
Biological function summary

PACS1 interacts with various adaptor proteins to regulate the localization of critical signaling molecules within the cell. Its function involves linking to clathrin and interacting with other proteins to form stable complexes ensuring the proper sorting of cargo proteins. This sorting is essential for cell signaling and responses. PACS1's ability to interact with kinases and phosphatases helps regulate the phosphorylation state of other proteins impacting diverse cellular pathways.

Pathways

PACS1 is involved in key intracellular trafficking and protein modification pathways. In particular it plays a significant role in the endocytic recycling pathway which is important in recycling membrane receptors. It closely interacts with clathrin and adaptor protein complexes. Additionally PACS1 is related to the apoptosis pathway through its regulatory effects on protein kinase C. By influencing these pathways PACS1 helps maintain cellular homeostasis and modulate cell survival and communication.

PACS1 mutations have been linked to PACS1 Syndrome a neurodevelopmental disorder characterized by delayed development and distinctive facial features. Additionally PACS1 has a role in some cancers likely due to its involvement in cell-cycle progression and apoptosis and it may interact with the p53 tumor suppressor protein in these contexts. Understanding the specific pathways and interactions involving PACS1 could help target therapeutic strategies for these conditions.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity).
See full target information PACS1
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:9250 PubMed40102459

2025

Identification of methionine metabolism related prognostic model and tumor suppressive functions of BHMT in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wenli Liu,Kaiheng Hu,Yaqing Fu,Tianmin Zhou,Qingmei Zhong,Wu Wang,Yang Gui,Ping Zhang,Di Yao,Xiaohong Yang,Weifeng Zhu,Zhuoqi Liu,Daya Luo,Yingqun Xiao
View all publications
style
left-column
style
left-column
style
right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com