重组Anti-PAC-2抗体[EPR9947(2)] (ab172909)
![Western blot - Anti-PAC-2 antibody [EPR9947(2)] (ab172909)](https://www.abcam.cn/ps/products/172/ab172909/Images/ab172909-195516-anti-pac-2-antibody-epr99472-western-blot.jpg "Western blot - Anti-PAC-2 antibody [EPR9947(2)] (ab172909)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR9947(2)] to PAC-2
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-PAC-2抗体[EPR9947(2)]
参阅全部 PAC-2 一抗 -
描述
兔单克隆抗体[EPR9947(2)] to PAC-2 -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,ICC/IF or IP -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
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免疫原
Synthetic peptide within Human PAC-2 aa 100-200. The exact sequence is proprietary.
Database link: Q969U7 -
阳性对照
- Caco-2, HepG2, Hela and Jurkat cell lysates
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR9947(2) -
同种型
IgG
相关产品
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Alternative Versions
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Isotype control
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Recombinant Protein
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Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab172909于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (1) |
1/1000 - 1/5000. Predicted molecular weight: 29 kDa.
|
| 说明 |
|---|
|
WB
1/1000 - 1/5000. Predicted molecular weight: 29 kDa. |
应用说明
Is unsuitable for Flow Cyt,ICC/IF or IP.
靶标
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功能
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. -
组织特异性
Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue. -
序列相似性
Belongs to the PSMG2 family. -
翻译后修饰
Degraded by the proteasome upon completion of 20S proteasome maturation. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 56984 Human
- Entrez Gene: 107047 Mouse
- Entrez Gene: 291539 Rat
- Omim: 609702 Human
- SwissProt: Q969U7 Human
- SwissProt: Q9EST4 Mouse
- Unigene: 464652 Human
- Unigene: 150701 Mouse
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别名
- CD40 ligand activated specific transcript 3 antibody
- CLAST3 antibody
- HCCA3 antibody
see all
图片
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Western blot - Anti-PAC-2 antibody [EPR9947(2)] (ab172909)All lanes : Anti-PAC-2 antibody [EPR9947(2)] (ab172909) at 1/1000 dilution
Lane 1 : Caco-2 cell lysate
Lane 2 : HepG2 cell lysate
Lane 3 : HeLa cell lysate
Lane 4 : Jurkat cell lysate
Predicted band size: 29 kDa -
![Anti-PAC-2 antibody [EPR9947(2)] (ab172909)](https://www.abcam.cn/ps/products/172/ab172909/Images/ab172909-2-benefits-of-recombinant-antibodies.png)
Anti-PAC-2 antibody [EPR9947(2)] (ab172909)
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab172909 被引用在 1 文献中.
- Wang X et al. PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer. Cell Rep Med 3:100741 (2022). PubMed: 36099919