AB273135

重组Anti-p40 - DeltaNp63抗体[rTP40/3690]

Name: p40 - DeltaNp63抗体[rTP40/3690] (ab273135)| Abcam中文官网
Brand: Abcam Limited
SKU: AB273135
Price: 4959 CNY
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Rating: 5 (1 reviews)

Anti-p40 - DeltaNp63 antibody [rTP40/3690]

Recombinant
了解详情

(1 Review)

(3 Publications)

Mouse Recombinant Monoclonal P63 antibody. Suitable for Flow Cyt, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TP63.

查看别名

KET, P63, P73H, P73L, TP73L, TP63, Tumor protein 63, p63, Chronic ulcerative stomatitis protein, Keratinocyte transcription factor KET, Transformation-related protein 63, Tumor protein p73-like, p40, p51, CUSP, p73L

3 Images

Flow Cytometry - Anti-p40 - DeltaNp63 antibody [rTP40/3690] (AB273135)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-p40 - DeltaNp63 antibody [rTP40/3690] (AB273135)

Flow cytometry analysis of PFA-fixed HeLa (human epithelial cell line from cervix adenocarcinoma) cells using ab273135 followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody [rTP40/3690] (AB273135)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody [rTP40/3690] (AB273135)

Paraffin-embedded human kidney tissue stained for p40 (deltaNp63) using ab273135 at 2 μg/ml in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody [rTP40/3690] (AB273135)

Paraffin-embedded human skin tissue stained for p40 (deltaNp63) using ab273135 at 2 μg/ml in immunohistochemical analysis.

不同偶联物与剂型 (1)

Carrier free

Anti-p40 - DeltaNp63 antibody [rTP40/3690] - BSA and Azide free

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

rTP40/3690

亚型

IgG1

轻链类型

kappa

不含载体蛋白

反应种属

Human

应用

Flow Cyt, IHC-P

applications

免疫原

Synthetic Peptide within Human TP63. The exact immunogen used to generate this antibody is proprietary information.

Q9H3D4

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-2 µg for 10^6 Cells", "FlowCyt-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The biological target p40 also known as ΔNp63 is an essential protein isoform of the p63 gene. This target weighs approximately 40 kDa and is expressed predominantly in epithelial tissues such as the basal layer of the skin and select organs. Due to its significant role in development and differentiation researchers often study p40 in the context of specific cancers using techniques like p40 immunostaining p40 IHC and p40 marker assays including the anti-p40 stain.

Biological function summary

The p40 protein acts as a transcription factor regulating epithelial stem cell maintenance and differentiation. It is an integral component of the tetrameric complex of the p63 protein family where it influences the transcription of genes involved in cell cycle control and apoptotic pathways. The ΔNp63 variant lacking the N-terminal transactivation domain plays an important role in blocking premature senescence contributing to cell proliferative capacity.

Pathways

P40 is involved in the Notch signaling and the PI3K/AKT signaling pathways. In Notch signaling p40 interacts alongside related proteins like bcl-2 or B28 impacting the regulation of cell fate and differentiation. The PI3K/AKT pathway involves p40 in processes essential for cell survival and proliferation often overlapping with proteins such as AKT and mTOR.

P40 significantly links to various forms of cancer especially squamous cell carcinoma and lung adenocarcinoma. Aberrant expression of ΔNp63 and its disruption in pathways contribute to the pathogenesis of these cancers. In squamous cell carcinoma p40 expression serves as an important biomarker distinguishing it from other tumor types connecting with proteins like Bcl-2 which are important in managing apoptotic resistance in cancerous cells.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

See full target information TP63

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Cancer 130:356-374 PubMed37861451

2023

Association of the m A reader IGF2BP3 with tumor progression and brain-specific metastasis in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Li,Jun Cao,Jianfeng Wang,Weidong Wu,Liren Jiang,Xing Sun

Diagnostic pathology 18:98 PubMed37649044

2023

Heterotopia of salivary gland tissue in the pancreas.

Applications

Unspecified application

Species

Unspecified reactive species

Sandrina Martens,Katarina Coolens,Catharina Olsen,Pierre Lefesvre,Ilse Rooman

Cell reports. Medicine 4:100911 PubMed36657446

2023

Using patient-derived organoids to predict locally advanced or metastatic lung cancer tumor response: A real-world study.

Applications

Unspecified application

Species

Unspecified reactive species

Han-Min Wang,Chan-Yuan Zhang,Kai-Cheng Peng,Ze-Xin Chen,Jun-Wei Su,Yu-Fa Li,Wen-Feng Li,Qing-Yun Gao,Shi-Ling Zhang,Yu-Qing Chen,Qing Zhou,Cong Xu,Chong-Rui Xu,Zhen Wang,Jian Su,Hong-Hong Yan,Xu-Chao Zhang,Hua-Jun Chen,Yi-Long Wu,Jin-Ji Yang

View all publications

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重组Anti-p40 - DeltaNp63抗体[rTP40/3690]