重组Anti-P2Y13抗体[EPR3698] (ab108444)
![Western blot - Anti-P2Y13 antibody [EPR3698] (ab108444)](https://www.abcam.cn/ps/products/108/ab108444/Images/ab108444-121177-anti-p2y13-antibody-epr3698-western-blot.jpg "Western blot - Anti-P2Y13 antibody [EPR3698] (ab108444)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR3698] to P2Y13
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
-
产品名称
Anti-P2Y13抗体[EPR3698]
参阅全部 P2Y13 一抗 -
描述
兔单克隆抗体[EPR3698] to P2Y13 -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,ICC/IF,IHC-P or IP -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
-
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
-
阳性对照
- Human spleen tissue lysate, HeLa cell lysate, HepG2 cell lysate, Jurkat cell lysate.
-
常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading... -
纯度
Tissue culture supernatant -
克隆
单克隆 -
克隆编号
EPR3698 -
同种型
IgG -
研究领域
相关产品
-
Alternative Versions
-
Isotype control
-
Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab108444于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000 - 1/5000. Predicted molecular weight: 41 kDa.
|
| 说明 |
|---|
|
WB
1/1000 - 1/5000. Predicted molecular weight: 41 kDa. |
应用说明
Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
靶标
-
功能
Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system. -
组织特异性
Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
细胞定位
Cell membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 53829 Human
- Entrez Gene: 74191 Mouse
- Entrez Gene: 310444 Rat
- Omim: 606380 Human
- SwissProt: Q9BPV8 Human
- SwissProt: Q9D8I2 Mouse
- SwissProt: Q6GUG4 Rat
- Unigene: 546396 Human
see all -
形式
There are 2 isoforms produced by alternative splicing. -
别名
- P2RY13 antibody
- FKSG77 antibody
- G protein coupled receptor 86 antibody
see all
图片
-
Western blot - Anti-P2Y13 antibody [EPR3698] (ab108444)All lanes : Anti-P2Y13 antibody [EPR3698] (ab108444) at 1/1000 dilution
Lane 1 : Human spleen tissue lysate
Lane 2 : HeLa cell lysate
Lane 3 : HepG2 cell lysate
Lane 4 : Jurkat cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 41 kDa -
![Anti-P2Y13 antibody [EPR3698] (ab108444)](https://www.abcam.cn/ps/products/108/ab108444/Images/ab108444-2-benefits-of-recombinant-antibodies.png)
Anti-P2Y13 antibody [EPR3698] (ab108444)
数据表及文件
-
SDS download
-
Datasheet download
文献 (4)
ab108444 被引用在 4 文献中.
- Jiao T et al. Erythrocytes from patients with ST-elevation myocardial infarction induce cardioprotection through the purinergic P2Y13 receptor and nitric oxide signaling. Basic Res Cardiol 117:46 (2022). PubMed: 36112326
- Kyrargyri V et al. P2Y13 receptors regulate microglial morphology, surveillance, and resting levels of interleukin 1ß release. Glia 68:328-344 (2020). PubMed: 31520551
- Zhou R et al. Activation of spinal dorsal horn P2Y13 receptors can promote the expression of IL-1ß and IL-6 in rats with diabetic neuropathic pain. J Pain Res 11:615-628 (2018). PubMed: 29628771
- Niu J et al. Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y12and P2Y13receptors in neuropathic pain rats. J Neuroinflammation 14:185 (2017). PubMed: 28899427