AB108444

重组Anti-P2Y13抗体[EPR3698]

Anti-P2Y13 antibody [EPR3698]

RabMAb
Recombinant
了解详情

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(4 Publications)

Rabbit Recombinant Monoclonal P2Y13 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications.

查看别名

GPR86, GPR94, FKSG77, P2RY13, P2Y purinoceptor 13, P2Y13, G-protein coupled receptor 86, G-protein coupled receptor 94

1 Images

Unknown

Western blot - Anti-P2Y13 antibody [EPR3698] (AB108444)

All lanes:

Western blot - Anti-P2Y13 antibody [EPR3698] (ab108444) at 1/1000 dilution

Lane 1:

Human spleen tissue lysate at 10 µg

Lane 2:

HeLa cell lysate at 10 µg

Lane 3:

HepG2 cell lysate at 10 µg

Lane 4:

Jurkat cell lysate at 10 µg

Predicted band size: 41 kDa

false

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR3698

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯度

Tissue culture supernatant

存储溶液

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

P2Y13 also known as P2RY13 is a G-protein coupled receptor part of the P2Y receptor family. It has a mass of approximately 42 kDa. Functionally P2Y13 recognizes extracellular nucleotides like ADP and initiates signaling cascades thereafter. This receptor is expressed in various tissues including the brain liver and immune cells. In the nervous system it plays a role in neurotransmission and might influence neuronal functions.

Biological function summary

P2Y13 participates in purinergic signaling. This pathway influences cellular responses and plays a role in multiple physiological processes. P2Y13 is not known to form part of a larger receptor complex but interacts with G-proteins to transmit signals within the cell. Its activity helps regulate lipid metabolism and influences energy homeostasis in the body.

Pathways

P2Y13 is involved in the ADP-mediated signaling pathway a critical component in the regulation of cholesterol and lipid metabolism. It interacts with proteins like G-protein subunits to activate downstream signaling pathways. In the broader context of these pathways P2Y13 supports cellular processes such as energy balance and detoxification of substances.

P2Y13 has been connected with cholesterol imbalance and related metabolic disorders. Its role in lipid homeostasis indicates it might be relevant in atherosclerosis a condition characterized by lipid accumulation in the arteries. P2Y13 also associates with neurological disorders due to its presence and role in neural tissues. It is connected to other purinergic receptors like P2Y12 in these disease contexts which collectively contribute to disease progression through dysregulated purinergic signaling.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.

See full target information P2RY13

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Basic research in cardiology 117:46 PubMed36112326

2022

Erythrocytes from patients with ST-elevation myocardial infarction induce cardioprotection through the purinergic P2Y receptor and nitric oxide signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Tong Jiao,Aida Collado,Ali Mahdi,Juliane Jurga,John Tengbom,Nawzad Saleh,Dinos Verouhis,Felix Böhm,Zhichao Zhou,Jiangning Yang,John Pernow

Glia 68:328-344 PubMed31520551

2019

P2Y receptors regulate microglial morphology, surveillance, and resting levels of interleukin 1β release.

Applications

Unspecified application

Species

Unspecified reactive species

Vasiliki Kyrargyri,Christian Madry,Ali Rifat,I Lorena Arancibia-Carcamo,Steffan P Jones,Victor T T Chan,Yajing Xu,Bernard Robaye,David Attwell

Journal of pain research 11:615-628 PubMed29628771

2018

Activation of spinal dorsal horn P2Y receptors can promote the expression of IL-1β and IL-6 in rats with diabetic neuropathic pain.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Zhou,Tao Xu,XiaoHong Liu,YuanShou Chen,DeYing Kong,Hong Tian,Mingxia Yue,Dujuan Huang,Junwei Zeng

Journal of neuroinflammation 14:185 PubMed28899427

2017

Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y and P2Y receptors in neuropathic pain rats.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Niu,Dujuan Huang,Rui Zhou,MingXia Yue,Tao Xu,Junna Yang,Li He,Hong Tian,XiaoHong Liu,Junwei Zeng

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-P2Y13抗体[EPR3698]

Anti-P2Y13 antibody [EPR3698]

Western blot - Anti-P2Y13 antibody [EPR3698] (AB108444)

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

免疫原